Zobrazeno 1 - 10
of 30
pro vyhledávání: '"I.-hung Shih"'
Autor:
Brandon Brown, Adrian S. Ray, Richard L. Mackman, Joy Y. Feng, Jay P. Parrish, I-hung Shih, Hui Hon Chung, Sharon K. Lee, Darius Babusis, Constantine G. Boojamra
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3354-3357
Ribonucleoside phosphonate analogues containing 2'-α-fluoro modifications were synthesized and their potency evaluated against HCV RNA polymerase. The diphosphophosphonate (triphosphate equivalent) adenine and cytidine analogues displayed potent inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d77d52d0d889c4e77ed4cd849de338c
https://doi.org/10.1016/j.bmcl.2013.03.095
https://doi.org/10.1016/j.bmcl.2013.03.095
Autor:
Margaret Robinson, Joy Y. Feng, Matthew Paulson, William E. Delaney, I-hung Shih, Weidong Zhong, Huiling Yang, Eric Mabery
Publikováno v:
Antiviral Research. 83:135-142
The hepatitis C virus infection system represents an important new tool for drug discovery. In this study, we compared the in vitro antiviral efficacy of several NS3 and NS5B inhibitors in genotype 1a, 1b, and 2a replicons and in the 2a infectious vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87518e3c1645ac7e10a7ec9a0ee53fca
https://doi.org/10.1016/j.antiviral.2009.04.003
https://doi.org/10.1016/j.antiviral.2009.04.003
Autor:
David A. Oare, I-hung Shih, Laura S. Lehman, Erik De Clercq, Eric Mabery, Steven S. Bondy, Weidong Zhong, Inge Vliegen, Matthew Paulson, Johan Neyts, Gerhard Pürstinger, Hans Reiser, Jan Paeshuyse, Nina Boddeker, Tine De Burghgraeve, William A. Lee
Publikováno v:
Journal of Hepatology
Background/Aims Following lead optimization, a set of substituted imidazopyridines was identified as potent and selective inhibitors of in vitro HCV replication. The particular characteristics of one of the most potent compounds in this series (5-[[3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034b0a9d32ab3e902fed4fe6a8554f20
http://europepmc.org/articles/PMC7114863
http://europepmc.org/articles/PMC7114863
Autor:
Michal Hocek, Lubomír Rulíšek, Radek Pohl, Lucie Zendlova, I-hung Shih, Pavel Hobza, Richard L. Mackman, Eric Mabery, Luděk Havran, Milan Vrabel, Blanka Klepetářová, Miroslav Fojta, Ivan Votruba
Publikováno v:
European Journal of Inorganic Chemistry. 2007:1752-1769
A series of ethynyl- or (4-boronophenyl)bipyridines and-phenanthrolines were prepared as versatile building blocks for attachment of bidentate N-ligands to other molecules via cross-coupling reactions. Their complexation with Ru(bpy)2Cl2 gave the cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e48f98dc86b8c97fedcd7c1676dcf6b
https://doi.org/10.1002/ejic.200700030
https://doi.org/10.1002/ejic.200700030
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5290-5293
A series of purine l -ribonucleosides 2a – 2i bearing diverse C-substituents (alkyl, aryl, hetaryl or hydroxymethyl) in the position 6 were prepared by Pd-catalyzed cross-coupling reactions of 6-chloro-9-(2,3,5-tri- O -acetyl-β- l -ribofuranosyl)p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bc69b6efecc6713bc76fdf6476f8d8
https://doi.org/10.1016/j.bmcl.2006.07.092
https://doi.org/10.1016/j.bmcl.2006.07.092
Energetic contribution of non-essential 5' sequence to catalysis in a hepatitis delta virus ribozyme
Autor:
Michael D. Been, I.-hung Shih
Publikováno v:
The EMBO Journal. 20:4884-4891
Hepatitis delta virus (HDV) ribozymes employ multiple catalytic strategies to achieve overall rate enhancement of RNA cleavage. These strategies include general acid-base catalysis by a cytosine side chain and involvement of divalent metal ions. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed06dc2db2d9d1b0b01d238828db4c7
https://doi.org/10.1093/emboj/20.17.4884
https://doi.org/10.1093/emboj/20.17.4884
Autor:
I-hung Shih, Michael D. Been
Publikováno v:
Proceedings of the National Academy of Sciences. 98:1489-1494
Ribozymes of hepatitis delta virus have been proposed to use an active-site cytosine as an acid-base catalyst in the self-cleavage reaction. In this study, we have examined the role of cytosine in more detail with the antigenomic ribozyme. Evidence t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01df7cc258678645c56809c3c9f8b939
https://doi.org/10.1073/pnas.98.4.1489
https://doi.org/10.1073/pnas.98.4.1489
Autor:
I-hung Shih, Michael D. Been
Publikováno v:
Biochemistry. 39:9055-9066
A minimal kinetic mechanism for a trans-acting ribozyme derived from the HDV antigenomic RNA self-cleaving element was established from steady-state, pre-steady-state, single-turnover, and binding kinetics. Rate constants for individual steps, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5183214bd95fb656a6c50dbf79bcb6a5
https://doi.org/10.1021/bi000499+
https://doi.org/10.1021/bi000499+
Publikováno v:
Science. 286:123-126
Ribozymes use a number of the same catalytic strategies as protein enzymes. However, general base catalysis by a ribozyme has not been demonstrated. In the hepatitis delta virus antigenomic ribozyme, imidazole buffer rescued activity of a mutant with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5de9b540dfcc2bc66fb690a203f3a63
https://doi.org/10.1126/science.286.5437.123
https://doi.org/10.1126/science.286.5437.123
Autor:
Yang Tian, Betty Peng, Weidong Zhong, Matthew Paulson, William A. Lee, Gerhard Pürstinger, Uli Schmitz, I-hung Shih, Johan Neyts, Xiaoping Qi, Tse Winston C, Steven S. Bondy, Huiling Yang, Eric Mabery, Hans Reiser, Laura S. Lehman, Jan Paeshuyse, Inge Vliegen, Martijn Fenaux, Christy M. Hebner, Gina Bahador
Publikováno v:
Antimicrobial agents and chemotherapy. 55(9)
GS-9190 (Tegobuvir) is a novel imidazopyridine inhibitor of hepatitis C virus (HCV) RNA replication in vitro and has demonstrated potent antiviral activity in patients chronically infected with genotype 1 (GT1) HCV. GS-9190 exhibits reduced activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0c95c10a4eca67ef085c251f5527d5
https://pubmed.ncbi.nlm.nih.gov/21746939
https://pubmed.ncbi.nlm.nih.gov/21746939