Single-cell profiling reveals preferential reduction of memory B cell subsets in cladribine patients that correlates with treatment response

Autor: Valerie E. Teschner, Ann-Katrin Fleck, Carolin Walter, Anna-Sophie Schwarze, Melanie Eschborn, Timo Wirth, Olga V. Steinberg, Andreas Schulte-Mecklenbeck, I-Na Lu, Marisol Herrera-Rivero, Claudia Janoschka, Jan D. Lünemann, Nicholas Schwab, Gerd Meyer zu Hörste, Julian Varghese, Catharina C. Gross, Refik Pul, Christoph Kleinschnitz, Simone Mader, Edgar Meinl, Monika Stoll, Heinz Wiendl, Luisa Klotz

Publikováno v: Therapeutic Advances in Neurological Disorders, Vol 16 (2023)

Background: Cladribine is a highly effective immunotherapy that is applied in two short-term courses over 2 years and reduces relapse rate and disease progression in patients with relapsing multiple sclerosis (MS). Despite the short treatment period,

Externí odkaz: https://doaj.org/article/620f3b4ae03d47ceb2b1381faa850bb4

Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma

Autor: Michael Heming, Svea Haessner, Jolien Wolbert, I-Na Lu, Xiaolin Li, Benjamin Brokinkel, Michael Müther, Markus Holling, Walter Stummer, Christian Thomas, Andreas Schulte-Mecklenbeck, Flavia de Faria, Marlon Stoeckius, Stephan Hailfinger, Georg Lenz, Kornelius Kerl, Heinz Wiendl, Gerd Meyer zu Hörste, Oliver M. Grauer

Publikováno v: Genome Medicine, Vol 14, Iss 1, Pp 1-19 (2022)

Abstract Background Primary central nervous system lymphoma (PCNSL) is a rare lymphoma of the central nervous system, usually of diffuse large B cell phenotype. Stereotactic biopsy followed by histopathology is the diagnostic standard. However, limit

Externí odkaz: https://doaj.org/article/f469e31eaaf1475f9487cd81a7d88824

Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates

Autor: Andris Kazaks, I-Na Lu, Sophie Farinelle, Alex Ramirez, Vincenzo Crescente, Benjamin Blaha, Olotu Ogonah, Tarit Mukhopadhyay, Mapi Perez de Obanos, Alejandro Krimer, Inara Akopjana, Janis Bogans, Velta Ose, Anna Kirsteina, Tatjana Kazaka, Nicola J. Stonehouse, David J. Rowlands, Claude P. Muller, Kaspars Tars, William M. Rosenberg

Publikováno v: BMC Biotechnology, Vol 17, Iss 1, Pp 1-11 (2017)

Abstract Background The lack of a universal influenza vaccine is a global health problem. Interest is now focused on structurally conserved protein domains capable of eliciting protection against a broad range of influenza virus strains. The long alp

Externí odkaz: https://doaj.org/article/e6429490dc22453698b74940fe830a21

Structure and applications of novel influenza HA tri-stalk protein for evaluation of HA stem-specific immunity.

Autor: I-Na Lu, Anna Kirsteina, Sophie Farinelle, Stéphanie Willieme, Kaspars Tars, Claude P Muller, Andris Kazaks

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0204776 (2018)

Long alpha helix (LAH) from influenza virus hemagglutinin (HA) stem or stalk domain is one of the most conserved influenza virus antigens. Expression of N-terminally extended LAH in E. coli leads to assembly of α-h elical homotrimer which is structu

Externí odkaz: https://doaj.org/article/125a45f78db84e85b515b4ba8325cd3e

Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial

Autor: Jesper D. Gunst, Marie H. Pahus, Miriam Rosás-Umbert, I-Na Lu, Thomas Benfield, Henrik Nielsen, Isik S. Johansen, Rajesh Mohey, Lars Østergaard, Vibeke Klastrup, Maryam Khan, Mariane H. Schleimann, Rikke Olesen, Henrik Støvring, Paul W. Denton, Natalie N. Kinloch, Dennis C. Copertino, Adam R. Ward, Winiffer D. Conce Alberto, Silke D. Nielsen, Maria C. Puertas, Victor Ramos, Jacqueline D. Reeves, Christos J. Petropoulos, Javier Martinez-Picado, Zabrina L. Brumme, R. Brad Jones, Julie Fox, Martin Tolstrup, Michel C. Nussenzweig, Marina Caskey, Sarah Fidler, Ole S. Søgaard

Publikováno v: Gunst, J D, Pahus, M H, Rosás-Umbert, M, Lu, I-N, Benfield, T, Nielsen, H, Johansen, I S, Mohey, R, Østergaard, L, Klastrup, V, Khan, M, Schleimann, M H, Olesen, R, Støvring, H, Denton, P W, Kinloch, N N, Copertino, D C, Ward, A R, Alberto, W D C, Nielsen, S D, Puertas, M C, Ramos, V, Reeves, J D, Petropoulos, C J, Martinez-Picado, J, Brumme, Z L, Jones, R B, Fox, J, Tolstrup, M, Nussenzweig, M C, Caskey, M, Fidler, S & Søgaard, O S 2022, ' Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1 : a phase 1b/2a, randomized trial ', Nature Medicine, vol. 28, no. 11, pp. 2424-2435 . https://doi.org/10.1038/s41591-022-02023-7
Gunst, J D, Pahus, M H, Rosás-Umbert, M, Lu, I-N, Benfield, T, Nielsen, H, Johansen, I S, Mohey, R, Østergaard, L, Klastrup, V, Khan, M, Schleimann, M H, Olesen, R, Støvring, H, Denton, P W, Kinloch, N N, Copertino, D C, Ward, A R, Alberto, W D C, Nielsen, S D, Puertas, M C, Ramos, V, Reeves, J D, Petropoulos, C J, Martinez-Picado, J, Brumme, Z L, Jones, R B, Fox, J, Tolstrup, M, Nussenzweig, M C, Caskey, M, Fidler, S & Søgaard, O S 2022, ' Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1 : a phase 1b/2a, randomized trial ', Nature Medicine . https://doi.org/10.1038/s41591-022-02023-7
Gunst, J D, Pahus, M H, Rosás-Umbert, M, Lu, I N, Benfield, T, Nielsen, H, Johansen, I S, Mohey, R, Østergaard, L, Klastrup, V, Khan, M, Schleimann, M H, Olesen, R, Støvring, H, Denton, P W, Kinloch, N N, Copertino, D C, Ward, A R, Alberto, W D C, Nielsen, S D, Puertas, M C, Ramos, V, Reeves, J D, Petropoulos, C J, Martinez-Picado, J, Brumme, Z L, Jones, R B, Fox, J, Tolstrup, M, Nussenzweig, M C, Caskey, M, Fidler, S & Søgaard, O S 2022, ' Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1 : a phase 1b/2a, randomized trial ', Nature Medicine, vol. 28, no. 11, pp. 2424-2435 . https://doi.org/10.1038/s41591-022-02023-7

Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this phase 1b/2a, open-label, randomized controlled trial using a four-grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134238a307c4936cfa0d89c5fd761241
https://pubmed.ncbi.nlm.nih.gov/36253609