Zobrazeno 1 - 10
of 216
pro vyhledávání: '"I.-D. Adler"'
Autor:
I.‐D. Adler
Publikováno v:
Toxikologie: Eine Einführung für Naturwissenschaftler und Mediziner
Autor:
I.-D. Adler, S.M. Attia
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 542:139-142
Nicotne has been tested in the conventional mouse bone marrow assay. Single doses of 1 mg/kg bw or 2 mg/kg bw were given by oral intubations and bone marrow was sampled at 24 h (1 mg/kg) or at 6, 12 and 18 h after treatment (2 mg/kg). Nicotine treatm
Publikováno v:
Mutagenesis. 17:383-389
Dacarbazine (DTIC) is a chemotherapeutic agent that has been successfully applied to treat various types of cancer such as Hodgkin's disease, malignant melanomas, soft tissue sarcomas and advanced neuroblastomas. Many of the patients are of reproduct
Publikováno v:
International Archives of Occupational and Environmental Health. 73:428-432
Germ cell mutagens are currently classified into three categories in the German List of MAK and BAT Values. These categories have been revised and extended by analogy with the new categories for carcinogenic chemicals. Germ cell mutagens produce heri
Publikováno v:
Human Genetics. 106:29-35
Publikováno v:
Genetical Research. 72:177-183
Ifosfamide induced dominant lethal mutations in spermatozoa of mice at doses of 200 and 300 mg/kg and in spermatids and spermatocytes at 600 mg/kg. The highest dose also induced specific-locus mutations in post-spermatogonial germ-cell stages of mice
Autor:
I.-D. ADLER
Publikováno v:
Annals of Human Genetics. 61:173-180
Autor:
James M Parry, E.M Parry, R Boumer, A Doherty, S Ellard, J O'Donovan, B Hoebee, J.M de Stoppelaar, G.R Mohn, A Önfelt, A Renglin, N Schultz, C Soderpalm-Bemdes, K.G Jensen, M Kirsch-Volders, A Elhajouji, P Van Hummelen, F Degrassi, A Antoccia, D Cimini, M Izzo, C Tanzarella, I.-D Adler, U Kliesch, G Schriever-Schwemmer, P Gasser, R Crebelli, A Carere, C Andreoli, R Benigni, P Leopardi, F Marcon, Z Zinjo, A.T Natarajan, J.J.W.A Boei, A Kappas, G Voutsinas, F.E Zarani, A Patrinelli, F Pachierotti, C Tiveron, P Hess
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 353:11-46
Although aneuploidy makes a significant contribution to both somatic and inherited disease the mechanisms by which environmental chemicals may induce numerical chromosome aberrations are only poorly defined. The European Union Project was aimed to fu
Autor:
I.-D. Adler, U. Kliesch
Publikováno v:
Mutation Research Letters. 283:249-253
The clastogenic effect of the antischistosomal drug hycanthone methanesulfonate was studied with the micronucleus test in mouse bone marrow cells. Male and female (102/El x C3H/El)F1 mice were treated with single i.p. injections. Bone marrow was samp
Publikováno v:
Mutagenesis. 6:297-302
Micronuclei (MN) in erythrocytes of mouse bone marrow cells were induced in vivo by the spindle poisons colchicine (COL) and vinblastine (VBL), by hydroquinone (HQ) and by the alkylating agent mitomycin C (MMC). Two different methods were applied to