Zobrazeno 1 - 10
of 239
pro vyhledávání: '"I. von Kügelgen"'
Autor:
Kristina Hoffmann, Jens Straßburger, D. A. Lutz, Younis Baqi, I. von Kügelgen, Christa E. Müller
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 12(11)
SummaryBackground The G-protein-coupled P2Y12-receptor plays a crucial role in platelet aggregation. Recently, ticagrelor was licensed as the first perorally active and reversible P2Y12-receptor antagonist. Objective The present study investigated th
Publikováno v:
British Journal of Pharmacology. 129:709-723
Cultured sympathetic neurones are depolarized and release noradrenaline in response to extracellular ATP, UDP and UTP. We examined the possibility that, in neurones cultured from rat thoracolumbar sympathetic ganglia, inhibition of the M-type potassi
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 359:360-369
Adenine and uracil nucleotides release noradrenaline from rat postganglionic sympathetic neurones by activation of P2X-receptors and distinct receptors for uracil nucleotides, respectively. The present study on cultured neurones of rat thoracolumbal
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Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 357:431-440
The aim of the study was to find out whether, and if so through which receptors, nucleotides modulate the release of noradrenaline in the rat pancreas. Segments of the pancreas were preincubated with [3H]-noradrenaline, superfused with medium contain
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 355:707-715
Experiments on hippocampal slices were carried out in order to find out whether the release of noradrenaline in the hippocampus can be modulated through P2-receptors. The slices were preincubated with [3H]-noradrenaline, superfused with medium contai
Publikováno v:
Neuroscience. 78:935-941
Postganglionic sympathetic neurons possess at least two excitatory receptors for nucleotides: P2X-purinoceptors and separate receptors for uracil nucleotides. 2,3,5,6,9,12 In cultured neurons from rat superior cervical ganglia (SCG), both receptors,
Publikováno v:
Journal of Autonomic Pharmacology. 16:371-376
1. We have previously shown that ATP is a co-transmitter of noradrenaline in the rat kidney. In the present study the release of ATP and noradrenaline from human kidney cortex was investigated. Vascular effects of ATP and stable analogues were tested
Publikováno v:
Journal of Autonomic Pharmacology. 16:413-416
1. Postganglionic sympathetic neurones possess both excitatory and inhibitory P2-purinoceptors. 2. The mechanisms of action of excitatory P2-purinoceptors have recently been studied on cultured sympathetic neurones of the rat. The receptors mediate f
Publikováno v:
Journal of molecular and cellular cardiology. 53(5)
In human coronary smooth muscle cells adenosine A(2B) receptors mediate the inhibition of platelet-derived growth factor (PDGF)-induced proliferation via induction of the transcription factor nuclear receptor subfamily 4, group A, member 1 (NR4A1). I