Výsledky vyhledávání - "I. Zimmerman"

Akademický článek

A cryptic pocket in Ebola VP35 allosterically controls RNA binding

Autor: Matthew A. Cruz, Thomas E. Frederick, Upasana L. Mallimadugula, Sukrit Singh, Neha Vithani, Maxwell I. Zimmerman, Justin R. Porter, Katelyn E. Moeder, Gaya K. Amarasinghe, Gregory R. Bowman

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)

Many viral proteins are thought to be unlikely candidates for drug discovery as they lack obvious drug binding sites. Here, the authors use computational approaches followed by experimental validation to identify a cryptic pocket within the Ebola vir

Externí odkaz: https://doaj.org/article/b1138d9e9bae403da917984ac9c6ee9b

Zobrazit plný text záznamu

Akademický článek

Conformational distributions of isolated myosin motor domains encode their mechanochemical properties

Autor: Justin R Porter, Artur Meller, Maxwell I Zimmerman, Michael J Greenberg, Gregory R Bowman

Publikováno v: eLife, Vol 9 (2020)

Myosin motor domains perform an extraordinary diversity of biological functions despite sharing a common mechanochemical cycle. Motors are adapted to their function, in part, by tuning the thermodynamics and kinetics of steps in this cycle. However,

Externí odkaz: https://doaj.org/article/a55697cfd1e6486e9b1c8264c308fb3b

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání