Zobrazeno 1 - 10
of 649
pro vyhledávání: '"I. Welsh"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101333- (2024)
Chronic kidney disease (CKD) poses a significant global health challenge, projected to become one of the leading causes of death by 2040. Current treatments primarily manage complications and slow progression, highlighting the urgent need for persona
Externí odkaz:
https://doaj.org/article/35ec8e53f7f8421a86be1722d96a5daf
Autor:
Amy J. Osborne, Agnieszka Bierzynska, Elizabeth Colby, Uwe Andag, Philip A. Kalra, Olivier Radresa, Philipp Skroblin, Maarten W. Taal, Gavin I. Welsh, Moin A. Saleem, Colin Campbell
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Chronic kidney diseases (CKD) have genetic associations with kidney function. Univariate genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with estimated glomerular filtration rate (eGFR
Externí odkaz:
https://doaj.org/article/720dcb90cc644525b4ddd6be5815d98b
Autor:
Monica Gamez, Hesham E. Elhegni, Sarah Fawaz, Kwan Ho Ho, Neill W. Campbell, David A. Copland, Karen L. Onions, Matthew J. Butler, Elizabeth J. Wasson, Michael Crompton, Raina D. Ramnath, Yan Qiu, Yu Yamaguchi, Kenton P. Arkill, David O. Bates, Jeremy E. Turnbull, Olga V. Zubkova, Gavin I. Welsh, Denize Atan, Simon C. Satchell, Rebecca R. Foster
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Background Diabetes mellitus is a chronic disease which is detrimental to cardiovascular health, often leading to secondary microvascular complications, with huge global health implications. Therapeutic interventions that can be applied to m
Externí odkaz:
https://doaj.org/article/330be12c4f514058b4ffcf2e9c2f0251
Autor:
Jennifer A. Hurcombe, Fern Barrington, Micol Marchetti, Virginie M.S. Betin, Emily E. Bowen, Abigail C. Lay, Lan Ni, Lusyan Dayalan, Robert J.P. Pope, Paul T. Brinkkoetter, Martin Holzenberger, Gavin I. Welsh, Richard J.M. Coward
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109749- (2024)
Summary: Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes i
Externí odkaz:
https://doaj.org/article/961bd36ce95841e4b8f27817b6223d15
Autor:
Monica Gamez, Hesham E. Elhegni, Sarah Fawaz, Kwan Ho Ho, Neill W. Campbell, David A. Copland, Karen L. Onions, Matthew J. Butler, Elizabeth J. Wasson, Michael Crompton, Raina D. Ramnath, Yan Qiu, Yu Yamaguchi, Kenton P. Arkill, David O. Bates, Jeremy E. Turnbull, Olga V. Zubkova, Gavin I. Welsh, Denize Atan, Simon C. Satchell, Rebecca R. Foster
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/1958e1ee5d4b47d2a70284f0b87673c4
Autor:
Michael Crompton, Joanne K. Ferguson, Raina D. Ramnath, Karen L. Onions, Anna S. Ogier, Monica Gamez, Colin J. Down, Laura Skinner, Kitty H. Wong, Lauren K. Dixon, Judit Sutak, Steven J. Harper, Paola Pontrelli, Loreto Gesualdo, Hiddo L. Heerspink, Robert D. Toto, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell, Matthew J. Butler
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
The glomerular endothelial glycocalyx (GEnGlx) forms the first part of the glomerular filtration barrier. Previously, we showed that mineralocorticoid receptor (MR) activation caused GEnGlx damage and albuminuria. In this study, we investigated wheth
Externí odkaz:
https://doaj.org/article/359f2aff3fef4349ad8f0cd82c87577a
Autor:
Jack Tuffin, Musleeha Chesor, Valeryia Kuzmuk, Tim Johnson, Simon C. Satchell, Gavin I. Welsh, Moin A. Saleem
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Tuffin et al. demonstrate a method for culturing conditionally immortalized human podocytes and GEnCs in 3D by forming spheroid cultures termed GlomSpheres, which are found to segregate in an organized manner. These are shown to establish a GBM-like
Externí odkaz:
https://doaj.org/article/3454bab16428421b8cab931ece01a44c
Autor:
Ross T. Campbell, Adam Jasilek, Harald Mischak, Esther Nkuipou‐Kenfack, Agnieszka Latosinska, Paul I. Welsh, Colette E. Jackson, Jane Cannon, Alex McConnachie, Christian Delles, John J.V. McMurray
Publikováno v:
ESC Heart Failure, Vol 7, Iss 4, Pp 1595-1604 (2020)
Abstract Aims Measurement of B‐type natriuretic peptide (BNP) or N‐terminal pro‐BNP is recommended as part of the diagnostic workup of patients with suspected heart failure (HF). We evaluated the diagnostic and prognostic utility of the novel u
Externí odkaz:
https://doaj.org/article/ef46f42dcbe34cdba9bc08a266064c61
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 514 (2023)
A small subset of people with nephrotic syndrome (NS) have genetically driven disease. However, the disease mechanisms for the remaining majority are unknown. Epigenetic marks are reversible but stable regulators of gene expression with utility as bi
Externí odkaz:
https://doaj.org/article/0013024ced094b5690e3cda5fa2816e9
Autor:
Jennifer A. Hurcombe, Abigail C. Lay, Lan Ni, Alexandra F. Barrington, Jim R. Woodgett, Susan E. Quaggin, Gavin I. Welsh, Richard J. Coward
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 8, Pp 498-510 (2019)
Abstract Podocytes are key cells in maintaining the integrity of the glomerular filtration barrier and preventing albuminuria. Glycogen synthase kinase 3 (GSK3) is a multi‐functional serine/threonine kinase existing as two distinct but related isof
Externí odkaz:
https://doaj.org/article/26255c42b79c4224a18d496e066cda30