Zobrazeno 1 - 10
of 211
pro vyhledávání: '"I. VandenBerg"'
Autor:
Carus H. Y. Lau, Emelie Flood, Mark J. Hunter, Billy J. Williams-Noonan, Karen M. Corbett, Chai-Ann Ng, James C. Bouwer, Alastair G. Stewart, Eduardo Perozo, Toby W. Allen, Jamie I. Vandenberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The fine tuning of biological electrical signaling is mediated by variations in the rates of opening and closing of gates that control ion flux through different ion channels. Human ether-a-go-go related gene (HERG) potassium channels have u
Externí odkaz:
https://doaj.org/article/972987d550f34a1a8904b0996298240b
Autor:
Seakcheng Lim, Melissa M. Mangala, Mira Holliday, Henrietta Cserne Szappanos, Samantha Barratt-Ross, Serena Li, Jordan Thorpe, Whitney Liang, Ginell N. Ranpura, Jamie I. Vandenberg, Christopher Semsarian, Adam P. Hill, Livia C. Hool
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/0597755221d841338cbe98d8ace2eb4a
Autor:
Kate L. Thomson, Connie Jiang, Ebony Richardson, Dominik S. Westphal, Tobias Burkard, Cordula M. Wolf, Matteo Vatta, Steven M. Harrison, Jodie Ingles, Connie R. Bezzina, Brett M. Kroncke, Jamie I. Vandenberg, Chai-Ann Ng
Publikováno v:
HGG Advances, Vol 5, Iss 2, Pp 100270- (2024)
Summary: Long QT syndrome (LQTS), caused by the dysfunction of cardiac ion channels, increases the risk of sudden death in otherwise healthy young people. For many variants in LQTS genes, there is insufficient evidence to make a definitive genetic di
Externí odkaz:
https://doaj.org/article/45cd34fb97534a84883eace8c131e642
Autor:
Yi C. Zeng, Meghna Sobti, Ada Quinn, Nicola J. Smith, Simon H. J. Brown, Jamie I. Vandenberg, Renae M. Ryan, Megan L. O’Mara, Alastair G. Stewart
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the efficacy and safety of compounds transported by OCT1, such as those
Externí odkaz:
https://doaj.org/article/7d16bee6f8884657b1aa4c5b3640243f
Autor:
Jordan Thorpe, Matthew D. Perry, Osvaldo Contreras, Emily Hurley, George Parker, Richard P. Harvey, Adam P. Hill, Jamie I. Vandenberg
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Background Atrial fibrillation is the most common arrhythmia syndrome and causes significant morbidity and mortality. Current therapeutics, however, have limited efficacy. Notably, many therapeutics shown to be efficacious in animal models h
Externí odkaz:
https://doaj.org/article/99622f8907c74cf0bf59bbddba760250
Autor:
Reema W. Aljassar, Qianyi Shen, Buthaina Albash, Jamie I. Vandenberg, Mohammad A. Ebrahim, Chai-Ann Ng
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101868- (2024)
Functional investigation of genetic variants found in long QT syndrome can provide evidence that is needed to confirm the genetic diagnosis and establish the cause of the condition. We performed functional assessment to determine the z-score, using a
Externí odkaz:
https://doaj.org/article/74bbb0ef9290474da5cd68717fed3959
Publikováno v:
eLife, Vol 12 (2023)
Many classes of drugs can induce fatal cardiac arrhythmias by disrupting the electrophysiology of cardiomyocytes. Safety guidelines thus require all new drugs to be assessed for pro-arrhythmic risk prior to conducting human trials. The standard safet
Externí odkaz:
https://doaj.org/article/164b1428954745ecb5d100dfce18f458
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Advances in next-generation sequencing have been exceptionally valuable for identifying variants in medically actionable genes. However, for most missense variants there is insufficient evidence to permit definitive classification of variants as beni
Externí odkaz:
https://doaj.org/article/a32dd2fd1ad84ff1a94824be606a5afb
Publikováno v:
Annals of Noninvasive Electrocardiology, Vol 28, Iss 1, Pp n/a-n/a (2023)
Abstract Introduction QTc prolongation is key in diagnosing long QT syndrome (LQTS), however 25%–50% with congenital LQTS (cLQTS) demonstrate a normal resting QTc. T wave morphology (TWM) can distinguish cLQTS subtypes but its role in acquired LQTS
Externí odkaz:
https://doaj.org/article/f486d6e3fba6407ea026b727f4402a4f
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008683 (2021)
Contemporary accounts of the initiation of cardiac arrhythmias typically rely on after-depolarizations as the trigger for reentrant activity. The after-depolarizations are usually triggered by calcium entry or spontaneous release within the cells of
Externí odkaz:
https://doaj.org/article/a9814cf5d73546f88b4a219c7141766b