Zobrazeno 1 - 10
of 49
pro vyhledávání: '"I. V. Mikhura"'
Publikováno v:
Russian Journal of Bioorganic Chemistry. 45:463-487
Biogenic polyamines spermine and spermidine are present in eukaryotic cells in micro- and millimolar concentrations, that determines the multiplicity of their functions and the necessity to support normal cell growth. Analogs and derivatives of sperm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a066843b93702b4ca11c19962558db8
https://doi.org/10.1134/s1068162019060207
https://doi.org/10.1134/s1068162019060207
Autor:
I. V. Mikhura, Gunnar Westman, Vladimir A. Brylev, Brijesh Rathi, Alexey A. Chistov, Ilya O. Aparin, Liubov I. Kozlovskaya, Dmitry I. Osolodkin, Vladimir A. Palyulin, Philipp P. Streshnev, Vladimir A. Korshun, Nikita A. Slesarchuk, Alexey A. Orlov, Alexey V. Ustinov, Sergey V. Kutyakov, Nidhi Jain
Publikováno v:
European Journal of Medicinal Chemistry. 171:93-103
Rigid amphipathic fusion inhibitors (RAFIs) are potent antivirals based on a perylene core linked with a nucleoside moiety. Sugar-free analogues of RAFIs, 5-(perylen-3-ylethynyl)uracil-1-acetic acid 1 and its amides 2, were synthesized using combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e251c54f299cbdca8f711d7274b79a5
https://doi.org/10.1016/j.ejmech.2019.03.029
https://doi.org/10.1016/j.ejmech.2019.03.029
Autor:
Vladimir A. Korshun, Alexey A. Chistov, Arsentiy V. Guz, Alexey V. Ustinov, I. V. Mikhura, Sergey V. Kutyakov
Publikováno v:
Organic Preparations and Procedures International. 49:377-381
Rigid amphipathic fusion inhibitors (RAFIs), 5-arylethynyl-uracil nucleosides with bulky aryl groups, constitute a class of compounds active against enveloped viruses.1 Derivatives of perylene, a p...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a2d0b634e769f1f88e6873b866ea36d
https://doi.org/10.1080/00304948.2017.1343040
https://doi.org/10.1080/00304948.2017.1343040
Autor:
M. S. Slyundina, A. V. Ustinov, Vladimir A. Korshun, D. A. Strizhevskaya, Roman S. Borisov, Maria A. Belyaeva, O. M. Ivanova, I. V. Mikhura, A. P. Topolyan, Andrey A. Formanovsky
Publikováno v:
Journal of Analytical Chemistry. 71:1326-1331
A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass incremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ce42010382234ac9e3425d11305832
https://doi.org/10.1134/s106193481614015x
https://doi.org/10.1134/s106193481614015x
Autor:
Andrey A Formanovsky, A. R. Simonian, M. A. Khomutov, Leena Alhonen, Alex R. Khomutov, Alexander O. Chizhov, Sergey N. Kochetkov, Jouko Vepsäläinen, Tuomo A. Keinänen, I. V. Mikhura, Mervi T. Hyvönen
Publikováno v:
Journal of Medicinal Chemistry
The biogenic polyamines, spermine (Spm) and spermidine, are organic polycations present in millimolar concentrations in all eukaryotic cells participating in the regulation of vital cellular functions including proliferation and differentiation. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c6c352cfa90120fe5031a178726c3b
https://pubmed.ncbi.nlm.nih.gov/31765147
https://pubmed.ncbi.nlm.nih.gov/31765147
Publikováno v:
Russian Chemical Bulletin. 64:1125-1133
A series of spacer-armed lactose derivatives with one or two O-sulfo groups in various positions, namely, 6-O-Su-Lac, 3´,6-O-Su2-Lac, 6´-O-Su-Lac, 6,6´-O-Su2-Lac, and 3´-O-Su-Lac (Su = SO3H), was synthesized starting from the same precursor. All
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::021b4aeb77983c66d7f332614630e62a
https://doi.org/10.1007/s11172-015-0989-0
https://doi.org/10.1007/s11172-015-0989-0
Autor:
Alexey V. Ustinov, Alexey A. Chistov, Nikita M. Ivanov, I. V. Mikhura, Philipp P. Streshnev, Sergey V. Kutyakov, Vladimir A. Korshun, Anton V. Glybin
Publikováno v:
Tetrahedron Letters. 57:4821-4823
Two novel analogues of the highly fluorescent and potent antiviral compound, 5-(perylen-3-ylethynyl)-2′-deoxyuridine, containing elongated rigid linkers, butadiyne and 1,4-diethynylphenylene, were synthesized from the corresponding trimethylsilyl a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::353d19dbd966613007a3485cdbd02465
https://doi.org/10.1016/j.tetlet.2016.09.050
https://doi.org/10.1016/j.tetlet.2016.09.050
Autor:
Anton V. Glybin, Alexey V. Ustinov, Vladimir A. Korshun, Alexey A. Chistov, Sergey V. Kutyakov, Ilya O. Aparin, I. V. Mikhura
Publikováno v:
Tetrahedron Letters. 57:1003-1005
3-Ethynylperylene 1 , an important precursor for fluorescent dyes, fluorescent nucleosides, and potent nucleoside-based antivirals, has been prepared from perylene on a multigram scale (3 steps, 55% overall yield). A simple synthesis of 2-ethynylpery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::942d03fe044e9455e8f7ab469066036e
https://doi.org/10.1016/j.tetlet.2016.01.067
https://doi.org/10.1016/j.tetlet.2016.01.067
Publikováno v:
Drug Testing and Analysis. 5:683-692
The synthetic cannabinoid, UR-144 ((1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone), was identified in commercial ‘legal high’ products (herbal, resin, and powder). Along with this, six related compounds were detected. The most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16634542f8e52d2b1871fcb72a98fab9
https://doi.org/10.1002/dta.1456
https://doi.org/10.1002/dta.1456
Autor:
A P, Topolyan, M A, Belyaeva, E E, Bykov, P V, Coodan, E A, Rogozhin, D A, Strizhevskaya, O M, Ivanova, A V, Ustinov, I V, Mikhura, I A, Prokhorenko, V A, Korshun, A A, Formanovsky
Publikováno v:
Acta Naturae
Detection of aminoglycoside antibiotics by MS or HPLC is complicated, because a) carbohydrate molecules have low ionization ability in comparison with other organic molecules (particularly in MALDI-MS), and b) the lack of aromatics and/or amide bonds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b38d07d1ed7c1eab03fa9e73e169cf1
https://pubmed.ncbi.nlm.nih.gov/27795853
https://pubmed.ncbi.nlm.nih.gov/27795853