Zobrazeno 1 - 10
of 49
pro vyhledávání: '"I. V. Mikhura"'
Publikováno v:
Russian Journal of Bioorganic Chemistry. 45:463-487
Biogenic polyamines spermine and spermidine are present in eukaryotic cells in micro- and millimolar concentrations, that determines the multiplicity of their functions and the necessity to support normal cell growth. Analogs and derivatives of sperm
Autor:
I. V. Mikhura, Gunnar Westman, Vladimir A. Brylev, Brijesh Rathi, Alexey A. Chistov, Ilya O. Aparin, Liubov I. Kozlovskaya, Dmitry I. Osolodkin, Vladimir A. Palyulin, Philipp P. Streshnev, Vladimir A. Korshun, Nikita A. Slesarchuk, Alexey A. Orlov, Alexey V. Ustinov, Sergey V. Kutyakov, Nidhi Jain
Publikováno v:
European Journal of Medicinal Chemistry. 171:93-103
Rigid amphipathic fusion inhibitors (RAFIs) are potent antivirals based on a perylene core linked with a nucleoside moiety. Sugar-free analogues of RAFIs, 5-(perylen-3-ylethynyl)uracil-1-acetic acid 1 and its amides 2, were synthesized using combined
Autor:
Andrey A Formanovsky, A. R. Simonian, M. A. Khomutov, Leena Alhonen, Alex R. Khomutov, Alexander O. Chizhov, Sergey N. Kochetkov, Jouko Vepsäläinen, Tuomo A. Keinänen, I. V. Mikhura, Mervi T. Hyvönen
Publikováno v:
Journal of Medicinal Chemistry
The biogenic polyamines, spermine (Spm) and spermidine, are organic polycations present in millimolar concentrations in all eukaryotic cells participating in the regulation of vital cellular functions including proliferation and differentiation. The
Autor:
Vladimir A. Korshun, Alexey A. Chistov, Arsentiy V. Guz, Alexey V. Ustinov, I. V. Mikhura, Sergey V. Kutyakov
Publikováno v:
Organic Preparations and Procedures International. 49:377-381
Rigid amphipathic fusion inhibitors (RAFIs), 5-arylethynyl-uracil nucleosides with bulky aryl groups, constitute a class of compounds active against enveloped viruses.1 Derivatives of perylene, a p...
Autor:
M. S. Slyundina, A. V. Ustinov, Vladimir A. Korshun, D. A. Strizhevskaya, Roman S. Borisov, Maria A. Belyaeva, O. M. Ivanova, I. V. Mikhura, A. P. Topolyan, Andrey A. Formanovsky
Publikováno v:
Journal of Analytical Chemistry. 71:1326-1331
A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass incremen
Publikováno v:
Russian Chemical Bulletin. 64:1125-1133
A series of spacer-armed lactose derivatives with one or two O-sulfo groups in various positions, namely, 6-O-Su-Lac, 3´,6-O-Su2-Lac, 6´-O-Su-Lac, 6,6´-O-Su2-Lac, and 3´-O-Su-Lac (Su = SO3H), was synthesized starting from the same precursor. All
Autor:
Alexey V. Ustinov, Alexey A. Chistov, Nikita M. Ivanov, I. V. Mikhura, Philipp P. Streshnev, Sergey V. Kutyakov, Vladimir A. Korshun, Anton V. Glybin
Publikováno v:
Tetrahedron Letters. 57:4821-4823
Two novel analogues of the highly fluorescent and potent antiviral compound, 5-(perylen-3-ylethynyl)-2′-deoxyuridine, containing elongated rigid linkers, butadiyne and 1,4-diethynylphenylene, were synthesized from the corresponding trimethylsilyl a
Autor:
Anton V. Glybin, Alexey V. Ustinov, Vladimir A. Korshun, Alexey A. Chistov, Sergey V. Kutyakov, Ilya O. Aparin, I. V. Mikhura
Publikováno v:
Tetrahedron Letters. 57:1003-1005
3-Ethynylperylene 1 , an important precursor for fluorescent dyes, fluorescent nucleosides, and potent nucleoside-based antivirals, has been prepared from perylene on a multigram scale (3 steps, 55% overall yield). A simple synthesis of 2-ethynylpery
Autor:
A P, Topolyan, M A, Belyaeva, E E, Bykov, P V, Coodan, E A, Rogozhin, D A, Strizhevskaya, O M, Ivanova, A V, Ustinov, I V, Mikhura, I A, Prokhorenko, V A, Korshun, A A, Formanovsky
Publikováno v:
Acta Naturae
Detection of aminoglycoside antibiotics by MS or HPLC is complicated, because a) carbohydrate molecules have low ionization ability in comparison with other organic molecules (particularly in MALDI-MS), and b) the lack of aromatics and/or amide bonds
Autor:
Faina Nakonechny, Marina Nisnevitch, Andrei A. Formanovsky, Yana Ilizirov, Yossi Paitan, I. V. Mikhura
Publikováno v:
Molecules, Vol 23, Iss 12, p 3152 (2018)
Molecules
Volume 23
Issue 12
Molecules
Volume 23
Issue 12
The well-known and rapidly growing phenomenon of bacterial resistance to antibiotics is caused by uncontrolled, excessive and inappropriate use of antibiotics. One of alternatives to antibiotics is Photodynamic Antibacterial Chemotherapy (PACT). In t