Zobrazeno 1 - 9
of 9
pro vyhledávání: '"I. V. Gushchina"'
Publikováno v:
Journal of Chemical Information and Modeling. 60:3692-3696
The ability of ligands to form crucial interactions with a protein target, characteristic for the substrate and/or inhibitors, could be considered a structural criterion for identifying potent binders among docked compounds. Structural filtration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f311a8890e5d62528b0ab600386118e8
https://doi.org/10.1021/acs.jcim.0c00303
https://doi.org/10.1021/acs.jcim.0c00303
Autor:
D. K. Nilov, Sergey Pushkarev, G. A. Manasaryan, Vytas K. Švedas, I. V. Gushchina, K. I. Kirsanov
Publikováno v:
Biochemistry. Biokhimiia. 85(1)
Poly(ADP-ribose) polymerase 1 (PARP-1) is a key DNA repair enzyme and an important target in cancer treatment. Conventional methods of studying the reaction mechanism of PARP-1 have limitations because of the complex structure of PARP-1 substrates; h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a93f4269292dff89a1ae5d3164f131a
https://pubmed.ncbi.nlm.nih.gov/32079521
https://pubmed.ncbi.nlm.nih.gov/32079521
Autor:
Alexandra L. Zakharenko, Maria V. Sukhanova, I. V. Gushchina, K. I. Yashina, Vytas K. Švedas, D. K. Nilov, Olga I. Lavrik
Publikováno v:
Biochemistry (Moscow). 83:152-158
We show for the first time that natural 2,5-diketopiperazines (cyclic dipeptides) can suppress the activity of the important anticancer target poly(ADP-ribose)polymerase (PARP). Cyclo(L-Ala-L-Ala) and cyclo(L-Ala-D-Ala) can interact with the key resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3616ba4e471233a26f129f34a9d10089
https://doi.org/10.1134/s0006297918020074
https://doi.org/10.1134/s0006297918020074
Publikováno v:
Acta Naturae. 9:59-66
The DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) represents a potential molecular target for anticancer therapy. A human Tdp1 model has been constructed using the methods of quantum and molecular mechanics, taking into account the ionizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bd7bf66f7d8bd53901e7ed92361907a
https://doi.org/10.32607/20758251-2017-9-2-59-66
https://doi.org/10.32607/20758251-2017-9-2-59-66
Autor:
Olga I. Lavrik, Vytas K. Švedas, Sergey N. Mikhailov, V I Tararov, A. V. Kulikov, D. K. Nilov, Alexandra L. Zakharenko, I. V. Gushchina
Publikováno v:
Acta Naturae. 8:108-115
The ability of 7-methylguanine, a nucleic acid metabolite, to inhibit poly (ADP-ribose) polymerase-1 (PARP-1) and poly(ADP-ribose)polymerase-2 (PARP-2) has been identified in silico and studied experimentally.The amino group at position 2 and the met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d1ac87cee0253f9c9351050b5367bf7
https://doi.org/10.32607/20758251-2016-8-2-108-115
https://doi.org/10.32607/20758251-2016-8-2-108-115
Autor:
Nariman F. Salakhutdinov, D. K. Nilov, Alexandra L. Zakharenko, Olga I. Lavrik, Olga A. Luzina, Maxim Kuprushkin, Aleksandr Filimonov, I. V. Gushchina, Ekaterina S Ilina, Olga D. Zakharova, Vytas K. Švedas, Nadezhda S Dyrkheeva
Publikováno v:
Planta medica. 85(2)
Usnic acid, a lichen secondary metabolite produced by a whole number of lichens, has attracted the interest of researchers owing to its broad range of biological activity, including antiviral, antibiotic, anticancer properties, and it possessing a ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661ba7647700609c99f40817c53436e1
https://pubmed.ncbi.nlm.nih.gov/30142660
https://pubmed.ncbi.nlm.nih.gov/30142660
Publikováno v:
Acta Naturae
The DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) represents a potential molecular target for anticancer therapy. A human Tdp1 model has been constructed using the methods of quantum and molecular mechanics, taking into account the ionizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2fdfb89cd0f0976183bc30318e72108
https://pubmed.ncbi.nlm.nih.gov/28740727
https://pubmed.ncbi.nlm.nih.gov/28740727
Autor:
Olga A. Luzina, Vytas K. Švedas, Olga A. Koval, I. V. Gushchina, Olga I. Lavrik, Nariman F. Salakhutdinov, D. K. Nilov, Nadezhda S Dyrkheeva, Alexandra L. Zakharenko
Publikováno v:
Journal of natural products. 79(11)
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a repair enzyme for stalled DNA-topoisomerase 1 (Top1) cleavage complexes and other 3′-end DNA lesions. TDP1 is a perspective target for anticancer therapy based on Top1-poison-mediated DNA damage. Several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc6507d2c9c0a2d18d3c1abb98072ca
https://pubmed.ncbi.nlm.nih.gov/27933897
https://pubmed.ncbi.nlm.nih.gov/27933897
Autor:
D K, Nilov, V I, Tararov, A V, Kulikov, A L, Zakharenko, I V, Gushchina, S N, Mikhailov, O I, Lavrik, V K, Švedas
Publikováno v:
Acta Naturae
The ability of 7-methylguanine, a nucleic acid metabolite, to inhibit poly(ADP-ribose)polymerase-1 (PARP-1) and poly(ADP-ribose)polymerase-2 (PARP-2) has been identified in silico and studied experimentally. The amino group at position 2 and the meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eab66aedf8b37f2b8d508fde00bba009
https://pubmed.ncbi.nlm.nih.gov/27437145
https://pubmed.ncbi.nlm.nih.gov/27437145