Zobrazeno 1 - 10
of 94
pro vyhledávání: '"I. V. Chernykh"'
Autor:
M. A. Kopanitsa, Yu. S. Tranova, I. V. Chernykh, A. V. Shchulkin, P. Yu. Mylnikov, O. V. Kalinkina, E. N. Yakusheva
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 60-68 (2023)
One way to analyze the activity of the ABCB1 protein is to assess the accumulation of its substrate fexofenadine (F.) inside the test cells. The goal is to develop and validate a method for the quantitative analysis of F. in Caco-2 cell lysate using
Externí odkaz:
https://doaj.org/article/ea7a6b00a0ef43a6b8b11b46ff903fee
Autor:
Yu. S. Tranova, A. A. Slepnev, I. V. Chernykh, A. V. Shchulkin, P. Yu. Mylnikov, N. M. Popova, M. I. Povetko, E. N. Yakusheva
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 12, Iss 2, Pp 87-94 (2023)
Introduction. Breast cancer resistance protein (BCRP) is an efflux membrane transporter that controls the pharmacokinetics of a large number of drugs. Its activity may change when taking some endo- and exogenous substances, thus making it a link in d
Externí odkaz:
https://doaj.org/article/a0fc4f5e332d4ee2a902ab9c13753670
Autor:
Yu. S. Tranova, A. V. Shchulkin, I. V. Chernykh, P. Yu. Mylnikov, A. A. Slepnev, E. N. Yakusheva
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 13, Iss 1, Pp 104-111 (2023)
Mitoxantrone is a marker substrate of breast cancer resistance protein (BCRP). BCRP is involved in a number of pharmacokinetic drug-drug interactions. The transporter’s possible saturability makes it advisable to use low concentrations of mitoxantr
Externí odkaz:
https://doaj.org/article/8960063842404d178ee5227c8c5e7a70
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 10, Iss 1, Pp 104-112 (2022)
The aim of the article is to evaluate the ABCB1 protein inhibition in the blood-brain barrier to increase the effectiveness of neuroprotective therapy for focal and global cerebral ischemia.Materials and methods. The work was performed on 103 male Wi
Externí odkaz:
https://doaj.org/article/f5c111684faf4b17bdd01a63c427341e
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 25-30 (2022)
Relevance. Ethylmethylhydroxypyridine succinate (EMHPS) is a reference domestic drug with pronounced antioxidant and antihypoxic activity. P-Glycoprotein (Pgp) is an ATP-dependent transport protein localized in tissue barriers and protecting cells an
Externí odkaz:
https://doaj.org/article/dd8a44852c5946dc9f16cfad7d26df6d
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 8, Iss 1, Pp 40-47 (2020)
The investigation of pharmacokinetics of marker substrates of carrier protein P-glycoprotein (Pgp, ABCB1-protein) including fexofenadine, is one of the methods of its functional activity evaluation.The aim of the study was to work out the HPLC method
Externí odkaz:
https://doaj.org/article/ac9edf860187416aa5b8521522c0fade
Autor:
N. M. Popova, A. V. Shchulkin, I. V. Chernykh, A. S. Esenina, M. M. Gradinar, E. N. Yakusheva
Publikováno v:
Акушерство, гинекология и репродукция, Vol 13, Iss 2, Pp 164-173 (2019)
This review addresses the function of the protein-transporter glycoprotein-P (Pgp, ABCB1 protein) and the expression of its encoding gene MDR1/mdr1 throughout the gestational period in humans and animals. We discuss the relationship between the trans
Externí odkaz:
https://doaj.org/article/02cc39edd35943f8ba648e22c5958e5e
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 35-38 (2017)
The article describes a method of quantitative analysis of III generation gistamine antagonist - fexofenadine in human bLood plasma by HPLC with UV detection at 220 nm. The analysis was performed in isocratic mode using Stayer chromatography system a
Externí odkaz:
https://doaj.org/article/d9c8953b88ac40b3b1a33467f6b615c9
Publikováno v:
Bulletin of Experimental Biology and Medicine. 174:431-434
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4b245472597686b153770962b1330b0
https://doi.org/10.1007/s10517-023-05723-3
https://doi.org/10.1007/s10517-023-05723-3
Publikováno v:
Doklady Biochemistry and Biophysics. 507:247-255
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c3fba36e86e0e3210130b1072c73a8f
https://doi.org/10.1134/s1607672922060096
https://doi.org/10.1134/s1607672922060096