Zobrazeno 1 - 10
of 68
pro vyhledávání: '"I. V. Alekseev"'
Autor:
S. V. Alekseeva, A. V. Sorokina, A. V. . Volkova, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, A. D. Zakharov, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 63-69 (2024)
Relevance. Acute toxicity testing is a common procedure for preclinical safety testing of potential agents. The purpose of this study was to study the acute toxicity of the compound GIZH-272, a new dibenzofuran oxime derivative with anti-ischemic and
Externí odkaz:
https://doaj.org/article/9f3cd64f6b014c02b599645f3bbfa364
Autor:
A. V. Sorokina, S. V. Alekseeva, I. A. Miroshkina, A. V. Volkova, K. S. Kachalov, A. D. Zakharov, I. V. Alekseev, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 51-57 (2023)
Relevance. Assay of acute toxicity is a mandatory step in a preclinical safety study of medicines and pharmaceutical substances. The purpose of this study was to determine the parameters of acute toxicity of the substance GIZH-298. Methods. GIZH-298
Externí odkaz:
https://doaj.org/article/ef86978f9c8a4bdfaae7aaadec7b4c86
Autor:
I. A. Miroshkina, A. V. Sorokina, A. V. Volkova, V. V. Zabrodina, I. V. Alekseev, K. S. Kachalov, A. D. Zakharov, S. V. Alekseeva
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 48-54 (2021)
Assessment of acute toxicity is a necessary stage of preclinical research of the substance GIZh-298. The aim of present research is study of acute toxicity GIZh-298. Methods. GIZh-298 was administered once intraperitoneally to mice at doses 200-330 m
Externí odkaz:
https://doaj.org/article/7bfeef5dee464153a9653469184eb86e
Autor:
S. V. Alekseeva, A. V. Sorokina, A. V. Volkova, V. V. Zabrodina, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, A. D. Zaharov
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 41-47 (2021)
Acute toxicity testing is a commonly accepted procedure for preclinical testing of the safety of potential drugs. The compound GIZh-290, which is a derivative of 4-phenylpyrrolidone– 2,6 - dimethylanilide (2-oxo-4-phenylpyrrolidine-1-yl) acetic aci
Externí odkaz:
https://doaj.org/article/db80459bf14e45c7ad27c46238858579
Autor:
A. V. Sorokina, S. V. Alekseeva, I. A. Miroshkina, K. S. Kachalov, A. D. Zaharov, I. V. Alekseev, A. S. Lapizkaya
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 52-60 (2021)
Presents results of a study of subchronic toxicity of homeopathic drug Dantinorm Baby in finished dosage form. The drug in the form of a ready solution was administered daily orally for one month to outbred rats Infanta and chinchilla rabbits at a do
Externí odkaz:
https://doaj.org/article/fac26546a5da461fa378cbaf6f01337d
Autor:
S. V. Alekseeva, A. V. Sorokina, A. V. Volkova, V. V. Zabrodina, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, A. D. Zaharov, P. Yu. Povarnina, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 46-50 (2019)
Resume. The study of acute and chronic toxicity of the finished dosage form (SFF) GSB-106, the active substance of which is the substituted dimeric peptide, hexamethylenediamine bis (N-monosuccinyl-L-seryl-L-lysine), which has antidepressant and neur
Externí odkaz:
https://doaj.org/article/e0abd8e20ff84910a7ef8e1979857f06
Autor:
A. V. Sorokina, S. V. Alekseeva, I. A. Miroshkina, A. V. Volkova, V. V. Zabrodina, K. S. Kachalov, I. V. Alekseev, A. D. Zaharov, P. Yu. Povarnina, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 51-58 (2019)
Resume. The paper presents the data of preclinical studies of the acute and chronic toxicity of the finished dosage form of the compound GK-2, which has neuroprotective properties. It has been established that GK-2 does not cause the death of animals
Externí odkaz:
https://doaj.org/article/db57a712217b442a81b26cd8d5f115e4
Autor:
I. A. Miroshkina, A. V. Sorokina, A. V. Volkova, K. S. Kachalov, I. V. Alekseev, A. D. Zaharov, S. V. Alekseeva, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 44-53 (2019)
Relevance. Assessment of chronic toxicity is a necessary stage of preclinical research of a newly synthesized pharmacological substance GML-1 having anxiolytic activity. The aim of present research is study of chronic toxicity of tablet form GML-1. M
Externí odkaz:
https://doaj.org/article/374174aaacc14d29a950efb79d1ffbd6
Publikováno v:
Моделирование и анализ информационных систем, Vol 22, Iss 6, Pp 852-861 (2015)
Traditional network architecture is inflexible and complicated. This observation has led to a paradigm shift towards software-defined networking (SDN), where network management level is separated from data forwarding level. This change was made possi
Externí odkaz:
https://doaj.org/article/1467bb7616c047b48ffdf7aa6979f2d1
Autor:
N. B. Dremova, I. V. Alekseev
Publikováno v:
Фармакоэкономика, Vol 6, Iss 3, Pp 23-26 (2015)
We present the results of the analysis of the monitoring of HIV / AIDS in the regions of the Central Federal District of Russia for the period 2009-2012. With the application of complex of economic and statistical methods were identified growth trend
Externí odkaz:
https://doaj.org/article/a63e008a3e3f4a889e8e9f115cc9ce3e