Výsledky vyhledávání - "I. Torres Aleman"

A Role for Astrocytic Insulin-Like Growth Factor I Receptors in the Response to Ischemic Insult

Autor: K. Suda, J. Pignatelli, L. Genis, A.M. Fernandez, E. Fernandez de Sevilla, I. Fernandez de la Cruz, A. Pozo-Rodrigalvarez, M. L. de Ceballos, S. Díaz-Pacheco, R. Herrero-Labrador, I. Torres Aleman

Increased neurotrophic support, including insulin-like growth factor I (IGF-I), is an important aspect of the adaptive response to ischemic insult. However, recent findings indicate that the IGF-I receptor (IGF-IR) in neurons plays a detrimental role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e07fce0422c35b38e43d538cb62741f3
https://doi.org/10.1101/2023.01.13.523904

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DIET INFLUENCES PERIPHERAL AMYLOID β METABOLISM: A ROLE FOR CIRCULATING INSULIN-LIKE GROWTH FACTOR I

Autor: Raquel Herrero-Labrador, Jaime Pignatelli, M.E. Fernández De Sevilla, Laura Martinez-Rachadell, Angel Trueba-Saiz, I. Torres Aleman, Sonia Diaz-Pacheco, Ana M. Fernandez

Obesity is a risk factor for Alzheimer’s disease (AD), but underlying mechanisms are not clear. We analyzed peripheral clearance of amyloid β (Aβ) in overweight mice because its systemic elimination may impact on brain Aβ load, a major landmark

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad53391663f81af1e97288e80979d33d
https://doi.org/10.1101/2020.07.09.180265

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Insulin-Like Growth Factor I Modulates Vulnerability to Stress Through Orexin Neurons

Autor: M.E. Fernández De Sevilla, Pablo Mendez, Jaime Pignatelli, Jonathan A. Zegarra-Valdivia, I. Torres Aleman

Knowledge of mechanisms involved in vulnerability/resilience to stress disorders is crucial for prevention and treatment schemes. We previously documented that insulin-like growth factor I (IGF-I) is associated to vulnerability to stress both in mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e18386aeefc30d61d368b859bd65ee5

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Insulin Peptides as Mediators of the Impact of Life Style in Alzheimer's disease

Autor: Andrea Santi, Agudo Fernández, I. Torres Aleman

Publikováno v: Brain Plasticity

The search for the cause of Alzheimer's disease (AD), that affects millions of people worldwide, is currently one of the most important scientific endeavors from a clinical perspective. There are so many mechanisms proposed, and so disparate changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c6aa9a7ae0560661d34d1cc0a5ea3c
https://pubmed.ncbi.nlm.nih.gov/30564544

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Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress:from mouse to man

Autor: I. Torres Aleman, Brenda W.J.H. Penninx, André Aleman, Mariska Bot, Andrea Santi

Publikováno v: Santi, A, Bot, M, Aleman, A, Penninx, B W J H & Aleman, I T 2018, ' Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress : from mouse to man ', Translational Psychiatry, vol. 8, no. 1, 142 . https://doi.org/10.1038/s41398-018-0196-5
Translational Psychiatry, 8:142. Nature Publishing Group
Translational Psychiatry
Translational Psychiatry, 8(1):142. Nature Publishing Group
Translational Psychiatry, Vol 8, Iss 1, Pp 1-11 (2018)

Individual susceptibility to anxiety disorders after maladaptive responses to stress is not well understood. We now report that while exploring stress responses in mice after traumatic brain injury (TBI), a condition associated to stress susceptibili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b91808c7344dc94464c3e765fdf9f8
https://research.vumc.nl/en/publications/f51afc5c-7189-4cf7-9d9f-aebae656fd38

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Akademický článek

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Akademický článek

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A Coordinated Action of Blood-Borne and Brain Insulin-Like Growth Factor I in the Response to Traumatic Brain Injury

Autor: Laura Genís, Andrea Santi, I. Torres Aleman

Publikováno v: Cerebral cortex (New York, N.Y. : 1991). 28(6)

In response to injury, the brain produces different neuroprotective molecules, such as insulin-like growth factor I (IGF-I). However, IGF-I is also taken up by the brain from the circulation in response to physiological stimuli. Herein, we analyzed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dcc4494161a18898058eb619adf772
https://pubmed.ncbi.nlm.nih.gov/28449086

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A role for astrocytes in cerebellar deficits in frataxin deficiency: Protection by insulin-like growth factor I

Autor: Agudo Fernández, JA Navarro, Laura Genís, I. Torres Aleman, Stephan Schneuwly, C Franco, Paloma Pérez-Domper

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Inherited neurodegenerative diseases such as Friedreich's ataxia (FRDA), produced by deficiency of the mitochondrial chaperone frataxin (Fxn), shows specific neurological deficits involving different subset of neurons even though deficiency of Fxn is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7572f2939945c63d8c3b53ab715fc85
http://hdl.handle.net/10261/200268

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