A Role for Astrocytic Insulin-Like Growth Factor I Receptors in the Response to Ischemic Insult

Autor: K. Suda, J. Pignatelli, L. Genis, A.M. Fernandez, E. Fernandez de Sevilla, I. Fernandez de la Cruz, A. Pozo-Rodrigalvarez, M. L. de Ceballos, S. Díaz-Pacheco, R. Herrero-Labrador, I. Torres Aleman

Increased neurotrophic support, including insulin-like growth factor I (IGF-I), is an important aspect of the adaptive response to ischemic insult. However, recent findings indicate that the IGF-I receptor (IGF-IR) in neurons plays a detrimental role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e07fce0422c35b38e43d538cb62741f3
https://doi.org/10.1101/2023.01.13.523904

Insulin-Like Growth Factor I Modulates Vulnerability to Stress Through Orexin Neurons

Autor: M.E. Fernández De Sevilla, Pablo Mendez, Jaime Pignatelli, Jonathan A. Zegarra-Valdivia, I. Torres Aleman

Knowledge of mechanisms involved in vulnerability/resilience to stress disorders is crucial for prevention and treatment schemes. We previously documented that insulin-like growth factor I (IGF-I) is associated to vulnerability to stress both in mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e18386aeefc30d61d368b859bd65ee5

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Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress:from mouse to man

Autor: I. Torres Aleman, Brenda W.J.H. Penninx, André Aleman, Mariska Bot, Andrea Santi

Publikováno v: Santi, A, Bot, M, Aleman, A, Penninx, B W J H & Aleman, I T 2018, ' Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress : from mouse to man ', Translational Psychiatry, vol. 8, no. 1, 142 . https://doi.org/10.1038/s41398-018-0196-5
Translational Psychiatry, 8:142. Nature Publishing Group
Translational Psychiatry
Translational Psychiatry, 8(1):142. Nature Publishing Group
Translational Psychiatry, Vol 8, Iss 1, Pp 1-11 (2018)

Individual susceptibility to anxiety disorders after maladaptive responses to stress is not well understood. We now report that while exploring stress responses in mice after traumatic brain injury (TBI), a condition associated to stress susceptibili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b91808c7344dc94464c3e765fdf9f8
https://research.vumc.nl/en/publications/f51afc5c-7189-4cf7-9d9f-aebae656fd38

A Coordinated Action of Blood-Borne and Brain Insulin-Like Growth Factor I in the Response to Traumatic Brain Injury

Autor: Laura Genís, Andrea Santi, I. Torres Aleman

Publikováno v: Cerebral cortex (New York, N.Y. : 1991). 28(6)

In response to injury, the brain produces different neuroprotective molecules, such as insulin-like growth factor I (IGF-I). However, IGF-I is also taken up by the brain from the circulation in response to physiological stimuli. Herein, we analyzed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dcc4494161a18898058eb619adf772
https://pubmed.ncbi.nlm.nih.gov/28449086