Zobrazeno 1 - 10
of 390
pro vyhledávání: '"I. Tarasova"'
Autor:
Yong Yean Kim, Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud, Silvia Pomella, Girma M. Woldemichael, Benjamin Z. Stanton, David Milewski, Joseph J. Barchi, John S. Schneekloth, Raj Chari, Joshua T. Kowalczyk, Shilpa R. Shenoy, Jason R. Evans, Young K. Song, Chaoyu Wang, Xinyu Wen, Hsien-Chao Chou, Vineela Gangalapudi, Dominic Esposito, Jane Jones, Lauren Procter, Maura O’Neill, Lisa M. Jenkins, Nadya I. Tarasova, Jun S. Wei, James B. McMahon, Barry R. O’Keefe, Robert G. Hawley, Javed Khan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. Here, we screen 62,643 compounds using an engineered cell
Externí odkaz:
https://doaj.org/article/62fcc583cb83489ca474d4e078b73633
Autor:
Biswajit Kundu, Szabolcs Dvorácskó, Abhishek Basu, Lenny Pommerolle, Kyu Ah Kim, Casey M. Wood, Eve Gibbs, Madeline Behee, Nadya I. Tarasova, Resat Cinar, Malliga R. Iyer
Publikováno v:
Molecules, Vol 29, Iss 13, p 3036 (2024)
The inhibition of soluble epoxide hydrolase (sEH) can reduce the level of dihydroxyeicosatrienoic acids (DHETs) effectively maintaining endogenous epoxyeicosatrienoic acids (EETs) levels, resulting in the amelioration of inflammation and pain. Conseq
Externí odkaz:
https://doaj.org/article/082c48c1d63a4249a7e91acb02de8c5e
Autor:
A.I. Kozhanov, G. I. Tarasova
Publikováno v:
Известия Иркутского государственного университета: Серия "Математика", Vol 42, Iss 1, Pp 59-74 (2022)
In the work the solvability of nonlocal boundary value problems for thirdorder pseudoparabolic equations in anisotropic spaces of Sobolev is studied. The condition is specified by a spatial variable that combines the generalized Samarsky-Ionkin condi
Externí odkaz:
https://doaj.org/article/db9e4ad93bf147d98b3fe400dbde54d7
Autor:
Pedro Andrade Bonilla, Cody L. Hoop, Karen Stefanisko, Sergey G. Tarasov, Sourav Sinha, Marc C. Nicklaus, Nadya I. Tarasova
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
STAT3 N-terminal domain is a promising molecular target for cancer treatment and modulation of immune responses. However, STAT3 is localized in the cytoplasm, mitochondria, and nuclei, and thus, is inaccessible to therapeutic antibodies. Its N-termin
Externí odkaz:
https://doaj.org/article/690d8fd7d1f24f30b45e11bf9c9bdefd
Autor:
Xiuxiu Lu, Venkata R. Sabbasani, Vasty Osei-Amponsa, Christine N. Evans, Julianna C. King, Sergey G. Tarasov, Marzena Dyba, Sudipto Das, King C. Chan, Charles D. Schwieters, Sulbha Choudhari, Caroline Fromont, Yongmei Zhao, Bao Tran, Xiang Chen, Hiroshi Matsuo, Thorkell Andresson, Raj Chari, Rolf E. Swenson, Nadya I. Tarasova, Kylie J. Walters
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Rpn13 is a substrate receptor of the 26S proteasome and an anti-cancer drug target. Here, the authors identify and characterize XL5, a lead compound that binds to the N-terminal Pru domain of human Rpn13 (hRpn13), solve the NMR structure of XL5-ligat
Externí odkaz:
https://doaj.org/article/08204c7dee354ca7ab5e0c3b7e0c28d6
Autor:
O. I. Tarasova, E. I. Kuhareva, S. K. Krasnitskaya, N. V. Mazurchik, M. Ya. Ngameni, N. A. Malinina, B. I. Zykin, P. P. Ogurtsov
Publikováno v:
Терапевтический архив, Vol 92, Iss 4, Pp 17-22 (2020)
Detection of liver fibrosis and steatosis at early stages is a difficult task for clinical practice, due to the lack of early signs in routine radiation diagnostics. Aim. To evaluate the efficacy of ultrasound shear elastography and ultrasound ste
Externí odkaz:
https://doaj.org/article/b4ab904bbe54434c90887ea0339eaf8e
Autor:
Gwen R. Buel, Xiang Chen, Raj Chari, Maura J. O’Neill, Danielle L. Ebelle, Conor Jenkins, Vinidhra Sridharan, Sergey G. Tarasov, Nadya I. Tarasova, Thorkell Andresson, Kylie J. Walters
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Human ubiquitin E3 ligase E6AP contains a Zn-binding AZUL domain. Here the authors identify and name RAZUL, a domain in proteasome substrate receptor hRpn10 that binds AZUL, recruiting E6AP to proteasomes, and they present the NMR structure of the RA
Externí odkaz:
https://doaj.org/article/3bff9a9995c849639e9e6e9b19f0338c
Publikováno v:
Геодинамика и тектонофизика, Vol 13, Iss 1 (2022)
The paper presents the results of the detailed structural analysis and 40Ar/39Ar dating of the deformations in the Golets Vysochaishii deposit area. The geological and structural studies showed the folded-deformation sequence from large lying folds t
Externí odkaz:
https://doaj.org/article/343f9f6bf62e41e08976ee99e376fb50
Autor:
Mariya I. Tarasova, Evgeniya M. Bronnikova, Olga S. Kulyamina, Lidia A. Vasileva, Anastasia S. Ponyashova
Publikováno v:
Política e Gestão Educacional, Vol 25, Iss esp.7 (2021)
The article reveals the theoretical aspect of the formation of prerequisites for improving the quality of education, approaches, methods, and criteria for assessing the quality of educational services. In preparing the article were used Russian and f
Externí odkaz:
https://doaj.org/article/a30fa5b1873b4598a45951940e4da016
Publikováno v:
Сибирский онкологический журнал, Vol 18, Iss 3, Pp 90-96 (2019)
Hepatocellular carcinoma (HCC) is one of the most common causes of death from cancer and is the final stage of chronic liver disease, usually occurring in patients with cirrhosis (CP). Chronic infection with hepatitis C virus (HCV) leads to progressi
Externí odkaz:
https://doaj.org/article/f216c71531994d9084bc499f0b53c4b6