Zobrazeno 1 - 10 of 287 pro vyhledávání: '"I. Svendsen"'
1
Characterisation of G418-induced metabolic load in recombinant CHO and BHK cells: effect on the activity and expression of central metabolic enzymes
Autor: P L Nørby, C A Yallop, I Svendsen, Helene Christine Reinbach, R Jensen
Publikováno v: Yallop, C A, Nørby, P L, Jensen, R, Reinbach, H C & Svendsen, I 2003, ' Characterisation of G418-induced metabolic load in recombinant CHO and BHK cells : effect on the activity and expression of central metabolic enzymes ', Cytotechnology, vol. 42, no. 2, pp. 87-99 . https://doi.org/10.1023/B:CYTO.0000009821.82741.8c
In a previous article (Yallop and Svendsen 2001), recombinant CHO and BHK cell lines, expressing the human glucagon receptor and the gastric inhibitory peptide receptor, respectively, showed reduced growth rates and altered nutrient utilisation when
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d30e0a003e18468df906c212b3d9a3
https://doi.org/10.1023/b:cyto.0000009821.82741.8c
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2
Structure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptor
Autor: Lisa Wright, H. Vissing, R.P. Bywater, Shirley M. Roberts, Roderick E. Hubbard, Ashley C. W. Pike, Andrzej M. Brzozowski, R.N. Skovgaard, I. Svendsen
Publikováno v: Acta Crystallographica Section D Biological Crystallography. 56:573-580
The monoclonal antibody hGR-2 F6 has been raised against the human glucagon receptor and shown to act as a competitive antagonist. As a first step in the structural characterization of the receptor, the crystal structure of the Fab fragment from this
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ae208a01ebfafc9513f886c49bbe6d
https://doi.org/10.1107/s090744490000233x
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3
Akademický článek
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4
Evidence for a Major Role for Glucagon in Regulation of Plasma Glucose in Conscious, Nondiabetic, and Alloxan-Induced Diabetic Rabbits
Autor: I. Svendsen, J. J. Holst, Brand Cl, Jørgensen Pn
Publikováno v: Diabetes. 45:1076-1083
Effects of glucagon immunoneutralization on plasma glucose, insulin, and glucagon were studied 2–4 h after intravenous injection of a high-affinity, monoclonal glucagon antibody into normal as well as moderately and severely alloxan (ALX)-induced d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e8a929c220d0bdd602e406518a0cde
https://doi.org/10.2337/diab.45.8.1076
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6
Role of glucagon in maintenance of euglycemia in fed and fasted rats
Autor: J. Warberg, Christian L. Brand, I. Svendsen, Jens J. Holst, U. Knigge, J S Kristensen, Peer Nobert Jørgensen
Publikováno v: CIÊNCIAVITAE
Europe PubMed Central
The role of glucagon in the regulation of blood glucose in fed and fasted anesthetized rats was studied by injecting intravenously 4 ml/kg of a high-capacity (40 nmol/ml) high-affinity (0.6 x 10(11) mol/l) monoclonal glucagon antibody. Blood glucose
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1c6005296385897c02315491ac35e0
https://doi.org/10.1152/ajpendo.1995.269.3.e469
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7
Isolation by anion-exchange of immunologically and enzymatically active human islet glutamic acid decarboxylase 65 overexpressed in Sf9 insect cells
Autor: E. Mortensen, Thomas Dyrberg, Kim Ry Hejnaes, Michael O. Marshall, A. J. Moody, Esper Boel, F. S. Larsen, I. Svendsen
Publikováno v: Diabetologia. 38:14-23
The enzymel-glutamic acid decarboxylase is a major autoantigen of the beta cell. Autoantibodies against this enzyme are observed before the onset of insulin-dependent diabetes mellitus (IDDM) in man and may be of predictive value. There is evidence t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc9b995e59e3e7303eaf320bab08b89
https://doi.org/10.1007/bf02369348
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8
The fabJ-encoded beta-ketoacyl-[acyl carrier protein] synthase IV from Escherichia coli is sensitive to cerulenin and specific for short-chain substrates
Autor: P von Wettstein-Knowles, M. Siggaard-Andersen, Margit Wissenbach, I Svendsen, Jo-Anne Chuck, Johan G. Olsen
Publikováno v: Proceedings of the National Academy of Sciences. 91:11027-11031
A fourth fatty acid condensing enzyme was isolated from Escherichia coli by its ability to restore elongating activity to a protein extract which had been treated with cerulenin, a condensing enzyme-specific inhibitor. The purified beta-ketoacyl-[acy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2122f4a0eba37108c170867905f45179
https://doi.org/10.1073/pnas.91.23.11027
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9
Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats
Autor: P. N. Jørgensen, J. J. Holst, I. Svendsen, Bidda Rolin, J S Kristensen, Christian L. Brand
Publikováno v: Diabetologia. 37:985-993
The role of glucagon in diabetic hyperglycaemia has been a matter of controversy because of difficulties in the production of selective glucagon deficiency. We developed a high-capacity (40 nmol/ml), high-affinity (0.6 x 10(11) l/mol) monoclonal gluc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d014bb1c4e94a93a6284265ed101ea3
https://doi.org/10.1007/bf00400461
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10
The effects of G418 on the growth and metabolism of recombinant mammalian cell lines
Autor: C A, Yallop, I, Svendsen
Publikováno v: Cytotechnology. 35(2)
It is widely reported that the growth of recombinant bacteria and yeast is adversely affected by increased metabolic load caused by the maintenance of plasmid copy number and recombinant protein expression. Reports suggest that recombinant mammalian
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a366de4e9c983cee1b56fa58cc78695a
https://pubmed.ncbi.nlm.nih.gov/19003287
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