Zobrazeno 1 - 10
of 50
pro vyhledávání: '"I. Sophie T. Bos"'
Autor:
Siti Farah Rahmawati, Rémon Vos, I. Sophie T. Bos, Huib A. M. Kerstjens, Loes E. M. Kistemaker, Reinoud Gosens
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Asthmatics have elevated levels of IL-17A compared to healthy controls. IL-17A is likely to contribute to reduced corticosteroid sensitivity of human airway epithelium. Here, we aimed to investigate the mechanistic underpinnings of this redu
Externí odkaz:
https://doaj.org/article/743b1d96993347b7928470e65d4f95bf
Autor:
Mariska P. M. van den Berg, Susan Nijboer-Brinksma, I. Sophie T. Bos, Maarten van den Berge, David Lamb, Martijn van Faassen, Ido P. Kema, Reinoud Gosens, Loes E. M. Kistemaker
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Asthma is a chronic respiratory disease in which the nervous system plays a central role. Sensory nerve activation, amongst others via Transient Receptor Potential Ankyrin 1 (TRPA1) channels, contributes to asthma characteristics
Externí odkaz:
https://doaj.org/article/390589a8cf6b4bccb3ab15de0bce3098
Autor:
Xinhui Wu, Eline M. van Dijk, John-Poul Ng-Blichfeldt, I. Sophie T. Bos, Chiara Ciminieri, Melanie Königshoff, Loes E.M. Kistemaker, Reinoud Gosens
Publikováno v:
Cells, Vol 8, Iss 10, p 1147 (2019)
Chronic obstructive pulmonary disease (COPD) represents a worldwide concern with high morbidity and mortality, and is believed to be associated with accelerated ageing of the lung. Alveolar abnormalities leading to emphysema are a key characteristic
Externí odkaz:
https://doaj.org/article/1b105df851b94cd7bd6d206157ae114e
Autor:
Miranda Van Eck, Menno Hoekstra, Ruud Out, I. Sophie T. Bos, J. Kar Kruijt, Reeni B. Hildebrand, Theo J.C. Van Berkel
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 136-146 (2008)
Scavenger receptor class B type I (SR-BI) functions as an HDL receptor that promotes the selective uptake of cholesteryl esters (CEs). The physiological role of SR-BI in VLDL metabolism, however, is largely unknown. SR-BI deficiency resulted in eleva
Externí odkaz:
https://doaj.org/article/ca8fdea9dea040ed841d2d639b08f1ee
Autor:
Xinhui Wu, Chiara Ciminieri, I. Sophie T. Bos, Manon E. Woest, Angela D'Ambrosi, René Wardenaar, Diana C.J. Spierings, Melanie Königshoff, Martina Schmidt, Loes E.M. Kistemaker, Reinoud Gosens
Publikováno v:
Environmental Pollution, 305:119292. ELSEVIER SCI LTD
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by inflammation and impaired tissue regeneration, and is reported as the fourth leading cause of death worldwide by the Centers for Disease Control and Preventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe7ac5003e1a9c0e2cd56edd7fa7ebe
https://research.rug.nl/en/publications/7fe6a1e9-97e2-4c86-987c-007712f60a05
https://research.rug.nl/en/publications/7fe6a1e9-97e2-4c86-987c-007712f60a05
Autor:
Xinhui Wu, I. Sophie T. Bos, Thomas M. Conlon, Meshal Ansari, Vicky Verschut, Luke van der Koog, Lars A. Verkleij, Angela D’Ambrosi, Aleksey Matveyenko, Herbert B. Schiller, Melanie Königshoff, Martina Schmidt, Loes E. M. Kistemaker, Ali Önder Yildirim, Reinoud Gosens
Publikováno v:
Science Advances, 8(12):eabj9949. AMER ASSOC ADVANCEMENT SCIENCE
Currently, there is no pharmacological treatment targeting defective tissue repair in chronic disease. Here, we used a transcriptomics-guided drug target discovery strategy using gene signatures of smoking-associated chronic obstructive pulmonary dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c9dcf85b59f4fb1b32ac6293df49d7
https://doi.org/10.1126/sciadv.abj9949
https://doi.org/10.1126/sciadv.abj9949
Autor:
Loes E. M. Kistemaker, Reinoud Gosens, Martina Schmidt, Herbert B. Schiller, Vicky Verschut, Lars A. Verkleij, Melanie Königshoff, Angela D’Ambrosi, Xinhui Wu, I. Sophie T. Bos, Thomas M. Conlon, Meshal Ansari, Ali Önder Yildirim, Aleksey V. Matveyenko
Currently, there is no pharmacological treatment targeting defective tissue repair in chronic disease. Here we utilized a transcriptomics-guided drug target discovery strategy using gene signatures of smoking-associated chronic obstructive pulmonary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb9112397153c8618fcd64db07ac4aaa
https://doi.org/10.1101/2021.05.18.444655
https://doi.org/10.1101/2021.05.18.444655
Autor:
Mariska P. M. van den Berg, Susan Nijboer-Brinksma, Martijn van Faassen, Maarten van den Berge, David J. Lamb, Ido P. Kema, Reinoud Gosens, I. Sophie T. Bos, Loes E. M. Kistemaker
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-15 (2021)
Respiratory Research
Respiratory Research, 22(1):48. BioMed Central Ltd.
Respiratory Research
Respiratory Research, 22(1):48. BioMed Central Ltd.
Background Asthma is a chronic respiratory disease in which the nervous system plays a central role. Sensory nerve activation, amongst others via Transient Receptor Potential Ankyrin 1 (TRPA1) channels, contributes to asthma characteristics including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a946ee64706f3f8dba2fb772d54d44a
https://doi.org/10.21203/rs.3.rs-88800/v1
https://doi.org/10.21203/rs.3.rs-88800/v1
Autor:
Maarten van den Berge, Tim Koopmans, Mark H. Menzen, Victor Guryev, Ron Smits, Gerard H. Koppelman, Reinoud Gosens, I. Sophie T. Bos, Laura Hesse, Kuldeep Kumawat, Elvira R M Bakker, Martijn C. Nawijn
Publikováno v:
Scientific Reports
Scientific Reports, 10(1):6754. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, 10(1):6754. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Asthma is a heterogeneous disease characterized by chronic inflammation and structural changes in the airways. The airway smooth muscle (ASM) is responsible for airway narrowing and an important source of inflammatory mediators. We and others have pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed7ca186f3b0f890f4a31d7f8152189
https://doi.org/10.1038/s41598-020-63741-x
https://doi.org/10.1038/s41598-020-63741-x
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
European Journal of Pharmaceutics and Biopharmaceutics, 130, 123-127. ELSEVIER SCIENCE BV
European Journal of Pharmaceutics and Biopharmaceutics, 130, 123-127. ELSEVIER SCIENCE BV
Budesonide is a hydrophobic glucocorticoid with high anti-inflammatory activity for the treatment of asthma, inflammatory bowel disease and rheumatoid arthritis. A micellar drug-delivery system based on lipid-DNA may provide a strategy to maximize it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137c1f7aef390b3b77da91d5c3cc0718
https://hdl.handle.net/11370/b0933bf2-0412-419b-aad6-a1370e7537b3
https://hdl.handle.net/11370/b0933bf2-0412-419b-aad6-a1370e7537b3