Zobrazeno 1 - 10
of 4 107
pro vyhledávání: '"I. Shapiro"'
Autor:
Kimberley M. DeMerle, Jason N. Kennedy, Chung-Chou H. Chang, Kevin Delucchi, David T. Huang, Max S. Kravitz, Nathan I. Shapiro, Donald M. Yealy, Derek C. Angus, Carolyn S. Calfee, Christopher W. Seymour
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Sepsis is a heterogeneous syndrome and phenotypes have been proposed using clinical data. Less is known about the contribution of protein biomarkers to clinical sepsis phenotypes and their importance for treatment effects in randomized trial
Externí odkaz:
https://doaj.org/article/ae5cd33625854879aaa5420c4d272404
Autor:
Vaya Chen, Jue Zhang, Jackie Chang, Mirza Ahmar Beg, Lance Vick, Dandan Wang, Ankan Gupta, Yaxin Wang, Ziyu Zhang, Wen Dai, Mindy Kim, Shan Song, Duane Pereira, Ze Zheng, Komal Sodhi, Joseph I. Shapiro, Roy L. Silverstein, Subramaniam Malarkannan, Yiliang Chen
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Visceral white adipose tissues (WAT) regulate systemic lipid metabolism and inflammation. Dysfunctional WAT drive chronic inflammation and facilitate atherosclerosis. Adipose tissue-associated macrophages (ATM) are the predominant immune cells in WAT
Externí odkaz:
https://doaj.org/article/b90896f82e094d6d9beb0115dbf0c24d
Autor:
John H. Lee, Larry A. Nathanson, Ryan C. Burke, Brian W. Anthony, Nathan I. Shapiro, Alon S. Dagan
Publikováno v:
Journal of the American College of Emergency Physicians Open, Vol 5, Iss 3, Pp n/a-n/a (2024)
Abstract Objectives This study aimed to compare the different respiratory rate (RR) monitoring methods used in the emergency department (ED): manual documentation, telemetry, and capnography. Methods This is a retrospective study using recorded patie
Externí odkaz:
https://doaj.org/article/3ec4848531e44c678647a22802e3689d
Autor:
Sarah J. Wu, MD, PhD, Justin J. Kim, Yeying Huang, BS, R. Taylor Durall, BS, Simone Becker, RN, Stephanie Canty, CNP, MSN, Stefania Molinaro, BS, Evan Pisick, MD, Geoffrey I. Shapiro, MD, PhD, Christopher A. French, MD, Jia Luo, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 1, Pp 100625- (2024)
We present the first known case of a patient with BRD2::NUTM1-driven NUT carcinoma. A 59-year-old woman presented with poorly differentiated squamous cell lung cancer metastatic to the pleura. Eventually, a positive NUT immunohistochemistry, NUT fluo
Externí odkaz:
https://doaj.org/article/b478d584323f4148b443ca10b9d2db17
Autor:
Komal Sodhi, Rebecca Pratt, Xiaoliang Wang, Hari Vishal Lakhani, Sneha S. Pillai, Mishghan Zehra, Jiayan Wang, Lawrence Grover, Brandon Henderson, James Denvir, Jiang Liu, Sandrine Pierre, Thomas Nelson, Joseph I. Shapiro
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108438- (2023)
Externí odkaz:
https://doaj.org/article/07230521f1774019ad70438bd53bf348
Autor:
J. Duranteau, D. De Backer, K. Donadello, N. I. Shapiro, S. D. Hutchings, A. Rovas, M. Legrand, A. Harrois, C. Ince
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-13 (2023)
Abstract The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the microcirculation of organs, which prevents them from ach
Externí odkaz:
https://doaj.org/article/6a99ad23b47f4615ae0638b045a6bfc1
Autor:
Stephen Macdonald, Erika Bosio, Gerben Keijzers, Sally Burrows, Moira Hibbs, Helen O’Donoghue, David Taylor, Ashes Mukherjee, Frances Kinnear, Lisa Smart, Juan-Carlos Ascencio-Lane, Edward Litton, John Fraser, Nathan I. Shapiro, Glenn Arendts, Daniel Fatovich, The REFRESH Trial Investigators
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Purpose To investigate the effect of IV fluid resuscitation on endothelial glycocalyx (EG) shedding and activation of the vascular endothelium and inflammation. Materials and methods A planned biomarker sub-study of the REFRESH trial in whic
Externí odkaz:
https://doaj.org/article/0d3db074e6d8466e9db36b16d6e0b514
Autor:
Anna V. Shapiro, Christoph Brühl, Klaus Klingmüller, Benedikt Steil, Alexander I. Shapiro, Veronika Witzke, Nadiia Kostogryz, Laurent Gizon, Sami K. Solanki, Jos Lelieveld
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Atmospheric ozone and oxygen protect the terrestrial biosphere against harmful ultraviolet (UV) radiation. Here, we model atmospheres of Earth-like planets hosted by stars with near-solar effective temperatures (5300 to 6300 K) and a broad r
Externí odkaz:
https://doaj.org/article/fb6440a1caf7405c8a5cf6b4ecd1b8a3
Autor:
Jeffrey Patterson-Fortin, Heta Jadhav, Constantia Pantelidou, Tin Phan, Carter Grochala, Anita K. Mehta, Jennifer L. Guerriero, Gerburg M. Wulf, Brian M. Wolpin, Ben Z. Stanger, Andrew J. Aguirre, James M. Cleary, Alan D. D’Andrea, Geoffrey I. Shapiro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Recently developed inhibitors of polymerase theta (POLθ) have demonstrated synthetic lethality in BRCA-deficient tumor models. To examine the contribution of the immune microenvironment to antitumor efficacy, we characterized the effects of
Externí odkaz:
https://doaj.org/article/1a29347110de4ea98e7dbf7d5ea3b928
Autor:
Alexander M. Kaizer, Nathan I. Shapiro, Jessica Wild, Samuel M. Brown, B. Jessica Cwik, Kimberly W. Hart, Alan E. Jones, Michael S. Pulia, Wesley H. Self, Clay Smith, Stephanie A. Smith, Patrick C. Ng, B. Taylor Thompson, Todd W. Rice, Christopher J. Lindsell, Adit A. Ginde
Publikováno v:
International Journal of Infectious Diseases, Vol 128, Iss , Pp 223-229 (2023)
Objectives: Effective and widely available therapies are still needed for outpatients with COVID-19. We aimed to evaluate the efficacy and safety of lopinavir/ritonavir (LPV/r) for early treatment of non-hospitalized individuals diagnosed with COVID-
Externí odkaz:
https://doaj.org/article/a331a0a5b9994c778243d39b26885423