Zobrazeno 1 - 10
of 23
pro vyhledávání: '"I. S. SIGAL"'
Autor:
J. P. Guare, Zugay Ja, William A. Schleif, S J deSolms, Paul L. Darke, E A Giuliani, I S Sigal, Joseph P. Vacca, William M. Sanders, Steven D. Young
Publikováno v:
Journal of Medicinal Chemistry. 34:1225-1228
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d0b91b6388941f4b1ea4a8076bc431
https://doi.org/10.1021/jm00107a050
https://doi.org/10.1021/jm00107a050
Autor:
I S Sigal, S J deSolms, Zugay Ja, J. M. Wiggins, J. P. Vacca, Samuel L. Graham, J. P. Guare, E A Giuliani, William M. Sanders, Paul L. Darke
Publikováno v:
Journal of medicinal chemistry. 34(9)
A series of tetrapeptide analogues of 1 (L-682,679), in which the carboxy terminus has been shortened and modified, was prepared and their inhibitory activity measured against the HIV protease in a peptide cleavage assay. Selected examples were teste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8da6dbba186808bacd8b16f0dfec43
https://pubmed.ncbi.nlm.nih.gov/1910089
https://pubmed.ncbi.nlm.nih.gov/1910089
Publikováno v:
Molecular pharmacology. 37(6)
The deletion of residues 222-229 from the hamster beta 2-adrenergic receptor (beta AR) resulted in an inability of the mutant receptor to couple to the guanine nucleotide-binding protein (G protein) Gs and to undergo the agonist-mediated sequestratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03f1bdb72b81a894dbbfb3e1d8c93b24
https://pubmed.ncbi.nlm.nih.gov/2163011
https://pubmed.ncbi.nlm.nih.gov/2163011
Publikováno v:
Journal of the American Chemical Society. 102:7252-7256
The binuclear Rh/sup 1/ complex Rh/sub 2/(bridge)/sub 4//sup 2 +/ (or Rh/sub 2//sup 2 +/) (bridge = 1,3-diisocyanopropane) reacts with 12 M HCl to form H/sub 2/ and (Rh/sub 2/(bridge)/sub 4/)/sub 2/Cl/sub 2//sup 4 +/ (or Rh/sub 4/Cl/sub 2//sup 4 +/).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::543907b784327d3ba778945b2d369f6d
https://doi.org/10.1021/ja00544a014
https://doi.org/10.1021/ja00544a014
Publikováno v:
Journal of Biological Chemistry. 259:5327-5332
The specifically mutated enzyme thiol beta-lactamase has been expressed in Escherichia coli by means of the trp promoter and purified to homogeneity. The gene for this enzyme results from a single base change N410 A----T in the gene of pBR322 RTEM be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8c4763daca07592365fe33dc121aee4
https://doi.org/10.1016/s0021-9258(17)42994-2
https://doi.org/10.1016/s0021-9258(17)42994-2
Autor:
Harry B. Gray, I. S. Sigal
Publikováno v:
Journal of the American Chemical Society. 103:2220-2225
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42636249db3ce008b6df445384f077ea
https://doi.org/10.1021/ja00399a014
https://doi.org/10.1021/ja00399a014
Autor:
Steven J. Milder, P. Ray Ryason, Harry B. Gray, George S. Hammond, I. S. Sigal, Kent R. Mann, Vincent M. Miskowski
Publikováno v:
Journal of the American Chemical Society. 101:4383-4385
Results of flash photolysis studies of the complexes Rh/sub 2/(bridge)/sub 4//sup 2 +/ where bridge = 1,3 diisocyanopropane are reported. The decay of the complex was found to obey second-order kinetics, and the product of the charges of the reactant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b2aab8ef134e7ac7490088166e3ec3
https://doi.org/10.1021/ja00509a061
https://doi.org/10.1021/ja00509a061
Publikováno v:
Chemischer Informationsdienst. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8741b4f256fae8757d6a3e816f8cfdb6
https://doi.org/10.1002/chin.198110340
https://doi.org/10.1002/chin.198110340
Autor:
P L, Darke, C T, Leu, L J, Davis, J C, Heimbach, R E, Diehl, W S, Hill, R A, Dixon, I S, Sigal
Publikováno v:
The Journal of biological chemistry. 264(4)
The protease of human immunodeficiency virus has been expressed in Escherichia coli and purified to apparent homogeneity. Immunoreactivity toward anti-protease peptide sera copurified with an activity that cleaved the structural polyprotein gag p55 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a89329ec2e943d2b29fbcc0abbb4ee5b
https://pubmed.ncbi.nlm.nih.gov/2644259
https://pubmed.ncbi.nlm.nih.gov/2644259
Autor:
I S, Sigal, G M, Smith, F, Jurnak, J D, Marsico-Ahern, J S, D'Alonzo, E M, Scolnick, J B, Gibbs
Publikováno v:
Anti-cancer drug design. 2(2)
The ras proteins have intrinsic biochemical properties that are similar to those of the guanine nucleotide binding regulatory proteins (G-proteins). Increased oncogenic potential results from amino acid substitutions that, by altering either the intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13aef7317493872901b3bb6448437099
https://pubmed.ncbi.nlm.nih.gov/3130069
https://pubmed.ncbi.nlm.nih.gov/3130069