Výsledky vyhledávání

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679

Autor: I S Sigal, S J deSolms, Zugay Ja, J. M. Wiggins, J. P. Vacca, Samuel L. Graham, J. P. Guare, E A Giuliani, William M. Sanders, Paul L. Darke

Publikováno v: Journal of medicinal chemistry. 34(9)

A series of tetrapeptide analogues of 1 (L-682,679), in which the carboxy terminus has been shortened and modified, was prepared and their inhibitory activity measured against the HIV protease in a peptide cleavage assay. Selected examples were teste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8da6dbba186808bacd8b16f0dfec43
https://pubmed.ncbi.nlm.nih.gov/1910089

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Separation of the structural requirements for agonist-promoted activation and sequestration of the beta-adrenergic receptor

Autor: A H, Cheung, R A, Dixon, W S, Hill, I S, Sigal, C D, Strader

Publikováno v: Molecular pharmacology. 37(6)

The deletion of residues 222-229 from the hamster beta 2-adrenergic receptor (beta AR) resulted in an inability of the mutant receptor to couple to the guanine nucleotide-binding protein (G protein) Gs and to undergo the agonist-mediated sequestratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03f1bdb72b81a894dbbfb3e1d8c93b24
https://pubmed.ncbi.nlm.nih.gov/2163011

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Akademický článek

Predicting the duration of action of β2-adrenergic receptor agonists: Ligand and structure-based approaches.

Autor: Chiesa L; Laboratoire d'Innovation Thérapeutique, Faculté de Pharmacie, UMR7200 CNRS Université de Strasbourg, 67400, Illkirch, France., Sick E; Laboratoire de Conception et Application de Molécules Bioactives, Faculté de Pharmacie, UMR7199 CNRS Université de Strasbourg, 67400, Illkirch, France., Kellenberger E; Laboratoire d'Innovation Thérapeutique, Faculté de Pharmacie, UMR7200 CNRS Université de Strasbourg, 67400, Illkirch, France.

Publikováno v: Molecular informatics [Mol Inform] 2023 Dec; Vol. 42 (12), pp. e202300141. Date of Electronic Publication: 2023 Nov 09.

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Solar energy storage reactions. Thermal and photochemical redox reactions of polynuclear rhodium isocyanide complexes

Autor: Harry B. Gray, I. S. Sigal, Kent R. Mann

Publikováno v: Journal of the American Chemical Society. 102:7252-7256

The binuclear Rh/sup 1/ complex Rh/sub 2/(bridge)/sub 4//sup 2 +/ (or Rh/sub 2//sup 2 +/) (bridge = 1,3-diisocyanopropane) reacts with 12 M HCl to form H/sub 2/ and (Rh/sub 2/(bridge)/sub 4/)/sub 2/Cl/sub 2//sup 4 +/ (or Rh/sub 4/Cl/sub 2//sup 4 +/).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::543907b784327d3ba778945b2d369f6d
https://doi.org/10.1021/ja00544a014

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Purification and properties of thiol beta-lactamase. A mutant of pBR322 beta-lactamase in which the active site serine has been replaced with cysteine

Autor: S R Petteway, B J Thomas, William F. DeGrado, I S Sigal

Publikováno v: Journal of Biological Chemistry. 259:5327-5332

The specifically mutated enzyme thiol beta-lactamase has been expressed in Escherichia coli by means of the trp promoter and purified to homogeneity. The gene for this enzyme results from a single base change N410 A----T in the gene of pBR322 RTEM be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8c4763daca07592365fe33dc121aee4
https://doi.org/10.1016/s0021-9258(17)42994-2

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Solar energy storage reactions involving polynuclear rhodium isocyanide complexes. Flash photolysis studies in aqueous sulfuric acid solutions

Autor: Steven J. Milder, P. Ray Ryason, Harry B. Gray, George S. Hammond, I. S. Sigal, Kent R. Mann, Vincent M. Miskowski

Publikováno v: Journal of the American Chemical Society. 101:4383-4385

Results of flash photolysis studies of the complexes Rh/sub 2/(bridge)/sub 4//sup 2 +/ where bridge = 1,3 diisocyanopropane are reported. The decay of the complex was found to obey second-order kinetics, and the product of the charges of the reactant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9b2aab8ef134e7ac7490088166e3ec3
https://doi.org/10.1021/ja00509a061

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Akademický článek

Adventures with the β2-adrenoceptor Receptor: A Career Long Interest in Agonising One of the Most Widely Studied GPCRs.

Autor: Fairhurst, Robin A.

Publikováno v: Chimia; 2024, Vol. 78 Issue 7/8, p483-498, 16p

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