Výsledky vyhledávání - "I. S. Nosulenko"

Akademický článek

Carboxyl-containing quinazolines and related heterocycles as carriers of anti-inflammatory activity

Autor: N. I. Krasovska, V V. Stavytskyi, I. S. Nosulenko, O. Yu. Voskoboinik, S. I. Kovalenko

Publikováno v: Zaporožskij Medicinskij Žurnal, Vol 24, Iss 1, Pp 91-101 (2022)

Active pharmaceutical ingredients whose structure combines aromatic or heterocyclic fragments with pharmacophore carboxylic group are widespread on pharmaceutical market. The isolation of COX-NSAIDs complexes and following X-ray studies allowed to ex

Externí odkaz: https://doaj.org/article/6abfd4203e1a40b0b74d3658c2c28248

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Akademický článek

Antiradical activity of novel 4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol derivatives

Autor: A. A. Safonov, I. S. Nosulenko

Publikováno v: Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, Vol 14, Iss 2, Pp 162-166 (2021)

The process of studying free radicals began in the middle of the last century (the free radical theory of aging in 1956). Multiple studies have revealed the effect of free radicals on the cells of the body and the development of various diseases, suc

Externí odkaz: https://doaj.org/article/d21371071a3e4bf881f1ef45bb555efd

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Akademický článek

Substituted pyrrolo[1,2-a][1,2,4]triazolo-(triazino-)[c]quinazolines - a promising class of lipoxygenase inhibitors

Autor: V. V. Stavytskyi, I. S. Nosulenko, O. O. Portna, V. M. Shvets, O. Yu. Voskoboynik, S. І. Kоvalenko

Publikováno v: Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, Vol 13, Iss 1, Pp 4-10 (2020)

The modern strategy of potential biologically active molecules search (“drug-design”) is based on several innovation approaches. The method of high thrоughрut biological screening and method of molecular modeling deserves the most attention amo

Externí odkaz: https://doaj.org/article/c078a3ea02da40b8b881efd3d355cf3e

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Akademický článek

2-([1,2,4]triazolo[1,5-c]quinazoline-2-yl-)alkyl-(alkaryl-,aryl-)-amines and their derivatives. Message 2. The synthesis of (3Н-quinazoline-4-ylidene)hydrazides N-protected aminoacids, using a variety of amine-protecting approaches. Physical-chemical prop

Autor: Yu. V. Martynenko, M. S. Kazunin, I. S. Nosulenko, G. G. Berest, S. І. Kоvalenko, O. M. Kamyshnyi, N. M. Polishchuk

Publikováno v: Zaporožskij Medicinskij Žurnal, Iss 3, Pp 413-420 (2018)

The synthetic potential of (3H-quinazoline-4-ylidene)hydrazides of carboxylic acids is significant in the context of new s-triazoloquinazolines creation and the obtained data of biological activity is a valid reason for the development of new methods

Externí odkaz: https://doaj.org/article/857193776b0b4e5b8b49648137f64ae5

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Akademický článek

3'-R-Spiro[cycloalkyl-1(2), (hetaryl-3(4), 6'-[1,2,4]triazino[2,3-c]quinazoline]-2'(7'H)-2-оnes as a perspective class of compounds with actoprotective activity

Autor: O. S. Kolomoets, О. Yu. Voskoboynik, I. S. Nosulenko, O. V. Krivoshey, A. I. Avramenko, G. G. Berest, S. I. Kovalenko

Publikováno v: Zaporožskij Medicinskij Žurnal, Iss 2, Pp 227-232 (2017)

Quinazolines and their derivatives are a perspective class of compounds with versatile biological activities. Their representatives are used in medical practice as sleeping, diuretic, antimicrobial and antitumor drugs. Continuing our search of perspe

Externí odkaz: https://doaj.org/article/7070b8a7eff44d6297c643bb7a04b9f0

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Akademický článek

Actoprotective activity of 6-monosubstituted 3-R-6,7-dihydro-2H-[1,2,4]triazino-[2,3-c]quinazoline-2-ones

Autor: O. S. Kolomoets, I. S. Nosulenko, О. Yu. Voskoboynik, G. G. Berest, S. I. Kovalenko, S. D. Trzhetsinsky

Publikováno v: Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, Iss 3, Pp 59-66 (2016)

Aim. Currently drugs with actoprotective activity are increasingly applied in sport medicine, military medicine, space medicine, emergence medicine, deep-see medicine rehabilitative medicine during high physical stresses. Purposeful search of actopro

Externí odkaz: https://doaj.org/article/7c7c4bcf30fd4a519d27906a1f8a7b85

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Akademický článek

Methodology for prediction of anticancer action of (2-oxo-2H-[1,2,4]¬triazino[2,3-c]-quinazolin-6-yl)thiones via QSAR and docking studies

Autor: I. S. Nosulenko, O. Yu. Voskoboynik, O. M. Antypenko, G. G. Berest, S. I. Kovalenko

Publikováno v: Zaporožskij Medicinskij Žurnal, Iss 1, Pp 99-104 (2015)

Aimed to elaborate new group of protein kinase inhibitors we conducted receptor-based screening (docking, QSAR modeling) and biochemical testing for derivatives of (2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thiones. Methods and results. This

Externí odkaz: https://doaj.org/article/f1825b40355847be9ee7c30c9c75ad3f

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