Zobrazeno 1 - 10
of 67
pro vyhledávání: '"I. S. Martynkevich"'
Autor:
D. V. Kustova, E. V. Motyko, A. N. Kirienko, T. N. Gert, I. V. Leppyanen, M. P. Bakay, E. V. Efremova, E. V. Morozova, E. G. Lomaia, V. A. Shuvaev, S. V. Sidorkevich, I. S. Martynkevich
Publikováno v:
Онкогематология, Vol 19, Iss 3, Pp 45-60 (2024)
Background. Most patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors achieve durable optimal responses. Loss of the achieved molecular response is observed in 15–30 % of patients. Mutations in the BCR::ABL kinase do
Externí odkaz:
https://doaj.org/article/521725f71f1941fc829156dab8fb0afe
Autor:
V. A. Shuvaev, I. S. Martynkevich
Publikováno v:
Онкогематология, Vol 19, Iss 1, Pp 21-39 (2024)
Polycythemia vera is a disease known since ancient times, however, until recent decades, diagnosis was carried out by exclusion, and therapy was symptomatic. The discovery of the pathogenetic role of mutations in the Janus kinase II gene has led to t
Externí odkaz:
https://doaj.org/article/b274499c21794733927f64b582123304
Autor:
E. O. Kunevich, I. S. Martynkevich, M. A. Mikhaleva, А. N. Bogdanov, E. V. Motyko, A. Yu. Kuvshinov, S. V. Sidorkevich, S. V. Voloshin
Publikováno v:
Онкогематология, Vol 18, Iss 4, Pp 181-195 (2023)
Aim. To study the prognostic significance of gene mutations and intracellular signaling pathways involved in lymphomagenesis in patients with follicular lymphoma using next generation sequencing (NGS).Materials and methods. The prospective study incl
Externí odkaz:
https://doaj.org/article/9be315686e504add8729ebae288c913c
Autor:
S. V. Voloshin, S. Yu. Linnikov, A. D. Garifullin, A. A. Kuzyaeva, A. V. Shmidt, A. Yu. Kuvshinov, A. N. Bogdanov, M. A. Mikhileva, I. S. Martynkevich, M. N. Zenina, S. V. Sidorkevich
Publikováno v:
Онкогематология, Vol 17, Iss 1, Pp 26-36 (2022)
Background. Over the past 15 years, the therapeutic breakthrough in the treatment of multiple myeloma observed primarily due to the emergence of new drugs. Since the characteristic of the disease is a chronic course with consecutive periods of remiss
Externí odkaz:
https://doaj.org/article/950e83cca2944d5084a1c58c5bd58213
Autor:
T. N. Subbotina, I. E. Maslyukova, A. A. Faleeva, P. A. Nikolaeva, A. S. Khazieva, E. A. Dunaeva, K. O. Mironov, L. B. Polushkina, I. S. Martynkevich, S. V. Vereshchagina, B. V. Barankin
Publikováno v:
Онкогематология, Vol 15, Iss 2, Pp 85-91 (2020)
Background. There are problems related to both quantitative assessment of an allele burden level of a mutant gene and interpretation of results in DNA samples with the burden level of the mutant allele less than 15–20 %, when using Sanger sequencin
Externí odkaz:
https://doaj.org/article/bc3b0376a2864fffaa914ecdf25e92fa
Autor:
N. Y. Semenova, N. I. Enukashvily, I. I. Kostorma, L. A. Belik, D. V. Baram, V. A. Balashova, S. V. Gritsaev, S. S. Bessmeltsev, D. I. Ostromyshenskii, I. S. Martynkevich
Publikováno v:
HemaSphere, Vol 6, Pp 1839-1840 (2022)
Externí odkaz:
https://doaj.org/article/6eba83dc11a34181806f14a790b6a2e4
Autor:
A. A. Zhernyakova, I. S. Martynkevich, V. A. Shuvaev, L. B. Polushkina, M. S. Fominykh, V. Yu. Udal’eva, I. I. Zotova, D. I. Shiсhbabaeva, S. V. Voloshin, S. S. Бессмельцев, A. V. Chechetkin, K. M. Abdulkadyrov
Publikováno v:
Онкогематология, Vol 12, Iss 2, Pp 30-38 (2017)
Background. Thrombosis and hemorrhage are the main category of complications, that affects the overall survival (OS), quality of life and therapy option choice in essential thrombocythemia (ET). Molecular marker presence (JAK2V617F (JAK2+), MPL (MPL+
Externí odkaz:
https://doaj.org/article/ff4d08c63d6c4263aec7f738cf2269b0
Publikováno v:
Онкогематология, Vol 11, Iss 1, Pp 24-33 (2016)
The article contains results of meta-analysis of experience in use of second-generation tyrosine kinase inhibitors – dasatinib. The results of clinical trials dasatinib therapy in chronic myelogenous leukemia imatinib-resistant or intolerant patien
Externí odkaz:
https://doaj.org/article/a280610f085d4557a6f25ecb8e03bb26
Publikováno v:
Онкогематология, Vol 10, Iss 3, Pp 28-42 (2015)
The literature review and own long-term polycythemia vera diagnosis and treatment experience are presented in this article. The results of newest advances in pathogenesis description, modern diagnostic techniques and treatment modalities in polycythe
Externí odkaz:
https://doaj.org/article/2e6c7e6963804fa4b06f4b771ace49aa
Publikováno v:
Онкогематология, Vol 10, Iss 2, Pp 26-36 (2015)
The newest advances in primary myelofibrosis (PMF) pathogenesis study, diagnostic and treatment approaches are presented in this article. The JAK-STAT signal pathway activation now recognized as main pathogenesis mechanism of PMF, it caused by JAK2,
Externí odkaz:
https://doaj.org/article/ba8e1bfea4b4417ab15195d98eb75939