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Low ergosterol content in yeast adh1 mutant enhances chitin maldistribution and sensitivity to paraquat-induced oxidative stress

Autor: Cristina Pungartnik, Martin Brendel, I. S. Ganda, G. Marisco, Samuel T. Saito

Publikováno v: Yeast (Chichester, England). 28(5)

Alcohol dehydrogenases catalyse the reversible oxidation of alcohols to aldehydes or ketones, with concomitant reduction of NAD(+) or NADP(+) . Adh1p is responsible for the reduction of acetaldehyde to ethanol, while Adh2p catalyses the reverse react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bcdf5bcaa603cb2a4e1496ac0be84f
https://pubmed.ncbi.nlm.nih.gov/21360751

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DNA repair mutant pso2 of Saccharomyces cerevisiae is sensitive to intracellular acetaldehyde accumulated by disulfiram-mediated inhibition of acetaldehyde dehydrogenase

Autor: Martin Brendel, Wolter R, Cristina Pungartnik, I. S. Ganda, G. Marisco

Publikováno v: Genetics and molecular research : GMR. 9(1)

Blocking aldehyde dehydrogenase with the drug disulfiram leads to an accumulation of intracellular acetaldehyde, which negatively affects the viability of the yeast Saccharomyces cerevisiae. Mutants of the yeast gene PSO2, which encodes a protein spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ca9c761386d53b47c02c82b3ed3376
https://pubmed.ncbi.nlm.nih.gov/20082270

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