Zobrazeno 1 - 10
of 45
pro vyhledávání: '"I. S. Farooqi"'
Autor:
Trevor Cole, Rajae Talbi, Margaret F. Lippincott, E. Terasawa, Yee-Ming Chan, Natalie D. Shaw, Janet E. Hall, Chrysanthi Fergani, Susan E. Stewart, S. Leon, I. S. Farooqi, Christopher M. Jones, Wiebke Arlt, Stephanie B. Seminara, Víctor M. Navarro
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 104:4304-4318
Context Kisspeptin–neurokinin B (NKB)–dynorphin neurons are critical regulators of the hypothalamic–pituitary–gonadal axis. NKB and dynorphin are hypothesized to influence the frequency of GnRH pulses, whereas kisspeptin is hypothesized to be
Autor:
Annette Andruck, Jan Kottner, Claudia Richter, Lara Lechner, Susanna Wiegand, I. S. Farooqi, Annika Vogt, Philipp Krabusch, Irina Jahnke, Keith Gottesdiener, Heiko Krude, Varvara Kanti, Lia Puder, Karine Clément, Christine Poitou, Ulrike Blume-Peytavi, Peter Kühnen
Background and Objectives: Gene mutations within the leptin-melanocortin signaling pathway lead to severe early-onset obesity. Recently, a phase 2 trial evaluated new pharmacological treatment options with the MC4R agonist setmelanotide in patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5ce1af4d7476f444a237f37c7b26bf
https://refubium.fu-berlin.de/handle/fub188/35902
https://refubium.fu-berlin.de/handle/fub188/35902
Autor:
Inês Barroso, Peter D. Sly, Jose Ramon Bilbao, Nicholas J. Timpson, Johan G. Eriksson, Maria M. Groen-Blokhuis, Sijmen A. Reijneveld, Dariusz Gruszfeld, George Davey Smith, Christine Power, Eva Reischl, Mandy Vogel, Andrew T. Hattersley, Øyvind Helgeland, Niina Pitkänen, Akram Alyass, Jean-Paul Langhendries, Elina Hyppönen, Kathrin Landgraf, Loreto Santa-Marina, Frank Geller, Christopher D. Brown, Elvira Verduci, Katja Pahkala, Olli T. Raitakari, Joaquin Escribano, Torben Hansen, Hakon Hakonarson, Barbara Heude, Bridget A. Knight, Maties Torrent, Robin N Beaumont, Judith M. Vonk, Estelle Lowry, Patrick G. Holt, Harold Snieder, Carol A. Wang, Mark I. McCarthy, Christine Frithioff-Bøjsøe, Tanja G. M. Vrijkotte, Natalia Vilor-Tejedor, Lisbeth Carstensen, Catharina E. M. van Beijsterveldt, Ville Karhunen, Virpi Lindi, Marjo-Riitta Järvelin, Tarunveer S. Ahluwalia, Jordi Sunyer, Jaakko T. Leinonen, Clare S. Murray, Klaus Bønnelykke, Thorkild I. A. Sørensen, André G. Uitterlinden, Janine F. Felix, John A. Curtin, Mika Kähönen, Jorma Viikari, Leo-Pekka Lyytikäinen, Oluf Pedersen, Carmen Iñiguez, Harri Niinikoski, Wieland Kiess, Kim F. Michaelsen, Evie Stergiakouli, Anni Heiskala, Alessandra Chesi, Craig E. Pennell, Mohammed H Zafarmand, Peter Rzehak, Kook K Teo, Aihuali Li, Marie Standl, Veit Grote, Momoko Horikoshi, Ellen A. Nohr, Eleanor Wheeler, Rachel M. Freathy, Iryna O. Fedko, Gerard H. Koppelman, Elisabeth Widen, Jens-Christian Holm, Raimo Joro, David Meyre, Mustafa Atalay, Theresia M. Schnurr, Camilla Schmidt Morgen, Adnan Custovic, Niels Grarup, Trevor A. Mori, Terho Lehtimäki, Christian Theil Have, Angela Simpson, Mads Melbye, Bjarke Feenstra, Lawrence J. Beilin, Stefan Johansson, Ioanna Ntalla, Martine Vrijheid, Mariona Bustamante, George Dedoussis, Sylvain Sebert, Jonas Bacelis, Carolina Medina-Gomez, Elisabeth Thiering, Ken K. Ong, Eleftheria Zeggini, Berthold Koletzko, Karine Clément, Bo L. Chawes, Mette Hollensted, Babette S. Zemel, Markus Scholz, Holger Kirsten, Antje Körner, Albertine J. Oldehinkel, Barbera D. C. van Schaik, Philippe Froguel, Vincent W. V. Jaddoe, Dorret I. Boomsma, Struan F.A. Grant, Loic Yengo, Jonathan P. Bradfield, Tenna Ruest Haarmark Nielsen, Suzanne Vogelezang, Jakob Stokholm, Pål R. Njølstad, Bo Jacobsson, Marc Vaudel, Peter J. van der Most, Andreas Kühnapfel, Mads Vendelbo Lind, Timo A. Lakka, Saskia Selzam, Robert Plomin, Marie-Aline Charles, Jouke-Jan Hottenga, Kalliope Panoutsopoulou, Fernando Rivadeneira, Rebecca K. Vinding, Hans Bisgaard, I. S. Farooqi, Joachim Heinrich, Diana L. Cousminer, Ricardo Closa-Monasterolo, Claire Monnereau
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1008718 (2020)
PLoS Genetics
Addi. Archivo Digital para la Docencia y la Investigación
instname
Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Grarup, N, Schnurr, T M, Hansen, T, Michaelsen, K F, Pedersen, O B, Stokholm, J, Lind, M V, Frithioff-Bøjsøe, C, Holm, J-C, Felix, J F & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', P L o S Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718
Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Lakka, T A, Grarup, N, Scholz, M, van der Most, P J, Monnereau, C, Stergiakouli, E, Heiskala, A, Horikoshi, M, Fedko, I O, Vilor-Tejedor, N, Cousminer, D L, Standl, M, Wang, C A, Viikari, J, Geller, F, Íñiguez, C, Pitkänen, N, Chesi, A, Bacelis, J, Yengo, L, Torrent, M, Ntalla, I, Helgeland, Ø, Selzam, S, Vonk, J M, Zafarmand, M H, Heude, B, Farooqi, I S, Alyass, A, Beaumont, R N, Have, C T, Rzehak, P, Bilbao, J R, Schnurr, T M, Barroso, I, Bønnelykke, K, Beilin, L J, Carstensen, L, Charles, M A, Chawes, B, Clément, K, Closa-Monasterolo, R, Custovic, A, Hansen, T, Morgen, C S, Nohr, E A & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLOS Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718
PLOS Genetics
PLoS Genetics (online), 16(10):e1008718. Public Library of Science
PLoS genetics, 16(10):e1008718. Public Library of Science
PLoS Genetics, Public Library of Science, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩
e1008718
PLOS GENETICS
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Fedko, I O, Groen-Blokhuis, M, Hottenga, J-J, Van Beijsterveldt, C E M, Vrijkotte, T G M, Boomsma, D I & Early Growth Genetics (EGG) Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLoS Genetics, vol. 16, no. 10, e1008718, pp. 1-26 . https://doi.org/10.1371/journal.pgen.1008718
PLoS Genetics, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩
PLoS Genetics, 16(10):e1008718, 1-26. Public Library of Science
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
r-FISABIO. Repositorio Institucional de Producción Científica
Curtin, J, Murray, C & et al. 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PL o S Genetics . https://doi.org/10.1371/journal.pgen.1008718
PLoS genetics, 16(10):e1008718. PUBLIC LIBRARY SCIENCE
PLoS Genet. 16:e1008718 (2020)
PLoS Genetics
Addi. Archivo Digital para la Docencia y la Investigación
instname
Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Grarup, N, Schnurr, T M, Hansen, T, Michaelsen, K F, Pedersen, O B, Stokholm, J, Lind, M V, Frithioff-Bøjsøe, C, Holm, J-C, Felix, J F & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', P L o S Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718
Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Lakka, T A, Grarup, N, Scholz, M, van der Most, P J, Monnereau, C, Stergiakouli, E, Heiskala, A, Horikoshi, M, Fedko, I O, Vilor-Tejedor, N, Cousminer, D L, Standl, M, Wang, C A, Viikari, J, Geller, F, Íñiguez, C, Pitkänen, N, Chesi, A, Bacelis, J, Yengo, L, Torrent, M, Ntalla, I, Helgeland, Ø, Selzam, S, Vonk, J M, Zafarmand, M H, Heude, B, Farooqi, I S, Alyass, A, Beaumont, R N, Have, C T, Rzehak, P, Bilbao, J R, Schnurr, T M, Barroso, I, Bønnelykke, K, Beilin, L J, Carstensen, L, Charles, M A, Chawes, B, Clément, K, Closa-Monasterolo, R, Custovic, A, Hansen, T, Morgen, C S, Nohr, E A & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLOS Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718
PLOS Genetics
PLoS Genetics (online), 16(10):e1008718. Public Library of Science
PLoS genetics, 16(10):e1008718. Public Library of Science
PLoS Genetics, Public Library of Science, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩
e1008718
PLOS GENETICS
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Fedko, I O, Groen-Blokhuis, M, Hottenga, J-J, Van Beijsterveldt, C E M, Vrijkotte, T G M, Boomsma, D I & Early Growth Genetics (EGG) Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLoS Genetics, vol. 16, no. 10, e1008718, pp. 1-26 . https://doi.org/10.1371/journal.pgen.1008718
PLoS Genetics, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩
PLoS Genetics, 16(10):e1008718, 1-26. Public Library of Science
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
r-FISABIO. Repositorio Institucional de Producción Científica
Curtin, J, Murray, C & et al. 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PL o S Genetics . https://doi.org/10.1371/journal.pgen.1008718
PLoS genetics, 16(10):e1008718. PUBLIC LIBRARY SCIENCE
PLoS Genet. 16:e1008718 (2020)
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association s
Autor:
Ellen L. Connor, M. H. Murad, Janet H. Silverstein, Jack A. Yanovski, I. S. Farooqi, Dennis M. Styne, Silva A. Arslanian
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 106:e2846-e2846
Autor:
Saito K, Inês Barroso, Liao L, Elana Henning, Qingchun Tong, Jiake Xu, van der Klaauw Aa, Elena G. Bochukova, Bert W. O'Malley, Tessa M. Cacciottolo, Katherine Lawler, Matthew C. Banton, Yan X, Julia M. Keogh, Pingwen Xu, Chunmei Wang, Zhu L, Jr. Hinton A, Yanlin He, I. S. Farooqi, Stadler Lkj, Yang Y, Audrey E. Hendricks, Stephen O'Rahilly, Mistry, Yong Xu
Publikováno v:
Nature Communications
Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated ST
Autor:
Craig E. Pennell, Chris Power, Johannes Hebebrand, David Meyre, Jean Dallongeville, Pma Sleiman, Mark I. McCarthy, Joel N. Hirschhorn, Nicholas J. Timpson, Nicole M. Warrington, Rjp van der Valk, Karani Santhanakrishnan Vimaleswaran, A Pouta, Mònica Guxens, Mariona Bustamante, Luis A. Moreno, M-R Jarvelin, Fredrick R. Schumacher, Aline Meirhaeghe, Charlotte E. Neville, Beatriz Valcarcel, Eleanor Wheeler, Hakon Hakonarson, Stephen O'Rahilly, D. S. Postma, Albert Hofman, Fernando Rivadeneira, Johan G. Eriksson, Hans Bisgaard, George McMahon, Vwv Jaddoe, I. S. Farooqi, Shikta Das, Diane J. Berry, Eskil Kreiner-Møller, Mohamed T. Hassanein, J. C. de Jongste, Joachim Heinrich, Olli T. Raitakari, Jessica L. Buxton, Aarno Palotie, W. J. Gauderman, Paul Elliott, C. Lecoeur, Reedik Mägi, Elina Hyppönen, C M van Duijn, B. St Pourcain, Frank D. Gilliland, Susan M. Ring, John P. Kemp, Rany M. Salem, Lyle J. Palmer, Terho Lehtimäki, Philippe Froguel, Ivonne Jarick, Cag Boreham, Elisabeth Thiering, Dorret I. Boomsma, Sfa Grant, A.-L. Hartikainen, André Scherag, Panagiotis Deloukas, Claus Holst, Jianhua Zhao, André G. Uitterlinden, Robert I. Berkowitz, Cecilia M. Lindgren, Tia Sorensen, Aif Blakemore, Mingyao Li, George Davey Smith, Dennis O. Mook-Kanamori, H R Taal, David M. Evans, Diana L. Cousminer, Matthew W. Gillman, Jonathan P. Bradfield, E. Widen, Anke Hinney, Inês Barroso
Publikováno v:
Nature Genetics, 44(5), 526-531e1. Nature Publishing Group
Nature genetics, vol 44, iss 5
Nature Genetics, 44(5), 526-+. Nature Publishing Group
Nature Genetics; Vol 44
Nature genetics
Nature Genetics, 44(5), 526-532. Nature Publishing Group
Ожирение и метаболизм, Vol 9, Iss 1 (2012)
Bradfield, J P, Taal, H R, Timpson, N J, Scherag, A, Lecoeur, C, Warrington, N M, Hypponen, E, Holst, C, Valcarcel, B, Thiering, E, Salem, R M, Schumacher, F R, Cousminer, D L, Sleiman, P M A, Zhao, J, Berkowitz, R I, Vimaleswaran, K S, Jarick, I, Pennell, C E, Evans, D M, St Pourcain, B, Berry, D J, Mook-Kanamori, D O, Hofman, A, Rivadeneira, F, Uitterlinden, A G, van Duijn, C M, van der Valk, R J P, de Jongste, J C, Postma, D S, Boomsma, D I, Gauderman, W J, Hassanein, M T, Lindgren, C M, Mägi, R, Boreham, C A G, Neville, C E, Moreno, L A, Elliott, P, Pouta, A, Hartikainen, A-L, Li, M, Raitakari, O, Lehtimäki, T, Eriksson, J G, Palotie, A, Dallongeville, J, Das, S, Deloukas, P, McMahon, G, Ring, S M, Kemp, J P, Buxton, J L, Blakemore, A I F, Bustamante, M, Guxens, M, Hirschhorn, J N, Gillman, M W, Kreiner-Møller, E, Bisgaard, H, Gilliland, F D, Heinrich, J, Wheeler, E, Barroso, I, O'Rahilly, S, Meirhaeghe, A, Sørensen, T I A, Power, C, Palmer, L J, Hinney, A, Widen, E, Farooqi, I S, McCarthy, M I, Froguel, P, Meyre, D, Hebebrand, J, Järvelin, M J, Jaddoe, V W V, Smith, G D, Hakonarson, H & Grant, S F A 2012, ' A genome-wide association meta-analysis identifies new childhood obesity loci ', Nature Genetics, vol. 44, no. 5, pp. 526-532 . https://doi.org/10.1038/ng.2247
Nature Genetics
Nature genetics, vol 44, iss 5
Nature Genetics, 44(5), 526-+. Nature Publishing Group
Nature Genetics; Vol 44
Nature genetics
Nature Genetics, 44(5), 526-532. Nature Publishing Group
Ожирение и метаболизм, Vol 9, Iss 1 (2012)
Bradfield, J P, Taal, H R, Timpson, N J, Scherag, A, Lecoeur, C, Warrington, N M, Hypponen, E, Holst, C, Valcarcel, B, Thiering, E, Salem, R M, Schumacher, F R, Cousminer, D L, Sleiman, P M A, Zhao, J, Berkowitz, R I, Vimaleswaran, K S, Jarick, I, Pennell, C E, Evans, D M, St Pourcain, B, Berry, D J, Mook-Kanamori, D O, Hofman, A, Rivadeneira, F, Uitterlinden, A G, van Duijn, C M, van der Valk, R J P, de Jongste, J C, Postma, D S, Boomsma, D I, Gauderman, W J, Hassanein, M T, Lindgren, C M, Mägi, R, Boreham, C A G, Neville, C E, Moreno, L A, Elliott, P, Pouta, A, Hartikainen, A-L, Li, M, Raitakari, O, Lehtimäki, T, Eriksson, J G, Palotie, A, Dallongeville, J, Das, S, Deloukas, P, McMahon, G, Ring, S M, Kemp, J P, Buxton, J L, Blakemore, A I F, Bustamante, M, Guxens, M, Hirschhorn, J N, Gillman, M W, Kreiner-Møller, E, Bisgaard, H, Gilliland, F D, Heinrich, J, Wheeler, E, Barroso, I, O'Rahilly, S, Meirhaeghe, A, Sørensen, T I A, Power, C, Palmer, L J, Hinney, A, Widen, E, Farooqi, I S, McCarthy, M I, Froguel, P, Meyre, D, Hebebrand, J, Järvelin, M J, Jaddoe, V W V, Smith, G D, Hakonarson, H & Grant, S F A 2012, ' A genome-wide association meta-analysis identifies new childhood obesity loci ', Nature Genetics, vol. 44, no. 5, pp. 526-532 . https://doi.org/10.1038/ng.2247
Nature Genetics
Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Austra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f880f61d6afe73241feeb22a7a0f214a
https://ora.ox.ac.uk/objects/uuid:96f4bbd6-9965-4488-bd10-c99d0e45ba6b
https://ora.ox.ac.uk/objects/uuid:96f4bbd6-9965-4488-bd10-c99d0e45ba6b
Publikováno v:
European Journal of Endocrinology. 166:951-955
Background: Spontaneous hyperinsulinaemic hypoglycaemia following gastric bypass surgery (GBS) is increasingly recognised. However, its pathophysiology remains unclear. Some patients require pancreatectomy. Medical therapy with calcium channel blocke
Autor:
Stella A. Nagel, I. S. Farooqi, Klaus-Michael Debatin, H. Muehleder, J. von Schnurbein, Martin Wabitsch, Anja Moss
Publikováno v:
Hormone Research in Paediatrics. 77:127-133
Background: Leptin deficiency leads to midluteal-phase defect or reduced testicular volume in adults, despite normal gonadotropin levels. All children documented to date with leptin deficiency were prepubertal with physiologically low gonadotropins p
Autor:
Ellen L. Connor, Dennis M. Styne, Silva A. Arslanian, M. Hassan Murad, I. S. Farooqi, Janet H. Silverstein, Jack A. Yanovski
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 102:2123-2124
The European Society of Endocrinology and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society.To formulate clinical practice guidelines for the assessment, treatment, and prevention of pediatric obesity.The participant
Autor:
Stephen O'Rahilly, I. S. Farooqi
Publikováno v:
The American Journal of Clinical Nutrition. 89:980S-984S
The identification of the hormone leptin by Friedman et al (1) in 1994 has proved to be a seminal observation in biomedical science. The discovery that a circulating protein secreted almost exclusively by adipocytes could regulate body weight through