Zobrazeno 1 - 10
of 14
pro vyhledávání: '"I. R. Horak"'
Autor:
L. G. Babich, S. G. Shlykov, O. A. Yesypenko, A. O. Bavelska-Somak, A. G. Zahoruiko, I. R. Horak, L. B. Drobot, S. O. Kosterin
Publikováno v:
The Ukrainian Biochemical Journal, Vol 94, Iss 2, Pp 24-30 (2022)
According to our earlier data, calix[4]arene chalcone amides modulate Ca ions exchange in the myometrium mitochondria and the level of inner membrane polarization that can potentially affect cell survival. To test this hypothesis, we studied the effe
Externí odkaz:
https://doaj.org/article/e4a3a92d825345df916fb24f66c87312
Autor:
A. Yu. Zhyvolozhnyi, I. R. Horak, D. S. Geraschenko, M. O. Gomozkova, O. O. Hudkova, S. J. Vainio, A. A. Samoylenko, L. B. Drobot
Publikováno v:
The Ukrainian Biochemical Journal, Vol 93, Iss 6, Pp 46-54 (2021)
Extracellular vesicles (EVs) are secreted by most cell types under both physiological and pathological conditions and were proposed to be actively involved in intercellular communication. The mode of EVs action is dependent on their cargos compositio
Externí odkaz:
https://doaj.org/article/1879c6942b644715a5ee17c81c8e29f8
Autor:
I. R. Horak, N. V. Latyshko, O. O. Hudkova, T. O. Kishko, O. V. Khudiakova, D. S. Gerashchenko, T. D. Skaterna, I. P. Krysiuk, S. G. Shandrenko, L. B. Drobot
Publikováno v:
The Ukrainian Biochemical Journal, Vol 92, Iss 4, Pp 24-34 (2020)
Excessive reactive oxygen species (ROS) production may lead to damage of cellular proteins, lipids and DNA, and cause cell death. Our previous findings demonstrated that increased level of adaptor protein Ruk/CIN85 contributes to breast cancer cells
Externí odkaz:
https://doaj.org/article/d39bb56abc58455395cdfd914ea7e1d2
ADAPTOR PROTEIN RUK/CIN85 IS INVOLVED IN THE GLUCOSE METABOLISM REPROGRAMMING IN BREAST CANCER CELLS
Autor:
M. I. Bekala, I. R. Horak, O. O. Gudkova, N. V. Latyshko, K. O. Tokarchuk, D. S. Geraschenko, M. O. Shkoda, L. B. Drobot
Publikováno v:
Biotechnologia Acta, Vol 15, Iss 2, Pp 47-48 (2022)
Aim. This study aimed to investigate the changes in glucose metabolism in mouse 4T1 breast adenocarcinoma cells with different levels of Ruk/CIN85 expression. Methods. We used 4T1 cells with stable overexpression (subline RukUp) or knockdown (subl
Externí odkaz:
https://doaj.org/article/9a3994bba538451a9199281fa347f1b0
Publikováno v:
Biotechnologia Acta, Vol 15, Iss 2, Pp 58-59 (2022)
Aim. To determine the role of Ruk/CIN85 in the control of breast adenocarcinoma cells metabolism, we performed systemic analysis of the activity levels/content of key enzymes/components of glycolysis and oxidative phosphorylation using as a model the
Externí odkaz:
https://doaj.org/article/327ddc41ed3940568b80109047e59afa
Publikováno v:
Biotechnologia Acta, Vol 15, Iss 2, Pp 74-75 (2022)
The purpose of this study was to test the hypothesis that Ruk/CIN85 overexpression/knockdown in melanoma cells may be involved in the regulation of EMT. Materials and methods. The mouse melanoma cell line B16-F10 and its sublines with up-/down-reg
Externí odkaz:
https://doaj.org/article/c83cfeec874044e0978be75117a4ba61
Publikováno v:
The Ukrainian Biochemical Journal, Vol 90, Iss 3, Pp 94-100 (2018)
The acquisition of chemoresistance in the course of tumor progression includes activation of membrane ABC transporters, detoxification enzymes, cell cycle deceleration and activation of specific signaling pathways such as Akt/mTOR, MAPK, NF-κB. Adap
Externí odkaz:
https://doaj.org/article/8fa99c5d91c149f5950907b94c40f8eb
Publikováno v:
The Ukrainian Biochemical Journal, Vol 88, Iss 1, Pp 119-125 (2016)
NADPH oxidases are key components of redox-dependent signaling networks involved in the control of cancer cell proliferation, survival and invasion. The data have been accumulated that demonstrate specific expression patterns and levels of NADPH oxid
Externí odkaz:
https://doaj.org/article/c1545214ce5e4d8eb79c5e827073771b
Autor:
I R, Horak, N V, Latyshko, O O, Hudkova, K O, Tokarchuk, T O, Kishko, O I, Yusova, L B, Drobot, A A, Tykhomyrov
Publikováno v:
Experimental oncology. 44(1)
Cell surface plasmin is involved in tumor growth and metastatic dissemination by regulating cancer cells adhesion, migration and invasion. Plasmin-induced cell detachment is accompanied by an increased rate of reactive oxygen species (ROS) generation
Autor:
A. Yu. Zhyvolozhnyi, I. R. Horak, T. D. Skaterna, O. V. Khudiakova, S. J. Vainio, A. A. Samoylenko, L. B. Drobot
Aim: To isolate and characterize extracellular vesicles (EVs) produced by mouse renal carcinoma Renca cells with different expression levels of the adaptor protein Ruk/CIN85 under normoxia and hypoxia conditions. Methods: The density gradient centrif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433e647c88ee446caa45f6301c83e11a
http://urn.fi/urn:nbn:fi-fe2022032525303
http://urn.fi/urn:nbn:fi-fe2022032525303