Zobrazeno 1 - 10
of 12
pro vyhledávání: '"I. P. Pogribny"'
Publikováno v:
Carcinogenesis. 19:1487-1494
DNA methylation at the 5-position on the cytosine ring in CpG dinucleotides (CpG sites) appears to play an important role in regulating gene expression. In general, there is an inverse relationship between promoter CpG site methylation and the potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117f8309161007101c9ce14471a520ac
https://doi.org/10.1093/carcin/19.8.1487
https://doi.org/10.1093/carcin/19.8.1487
Autor:
I P, Pogribny
Publikováno v:
Experimental oncology. 32(3)
The development of cancer is a complex multifactorial process traditionally viewed as the stepwise accumulation of genetic alterations. However, recent advances in field of cancer research have established that all major human cancers, in addition to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ce0e3ff4ac765c2eb554fa8f5e962de
https://pubmed.ncbi.nlm.nih.gov/21403606
https://pubmed.ncbi.nlm.nih.gov/21403606
Akademický článek
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Publikováno v:
Experimental oncology. 29(4)
The elevation in plasma homocysteine (Hcy) concentrations has been associated with several types of human cancer; however, the major unanswered question whether or not hyperhomocysteinemia is associated with cancer pathogenesis and is an indicator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb12d407f3fc8b1696da3a8aaeeb6e6e
https://pubmed.ncbi.nlm.nih.gov/18199980
https://pubmed.ncbi.nlm.nih.gov/18199980
Publikováno v:
Experimental oncology. 28(4)
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at posttranscriptional level. They are involved in cellular development, differentiation, proliferation and apoptosis and play a significant role in cancer. This re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c89bb5430c2b68ac86247e6a7185946d
https://pubmed.ncbi.nlm.nih.gov/17285108
https://pubmed.ncbi.nlm.nih.gov/17285108
Mechanisms of cellular adaptation may have some commonalities across different organisms. Revealing these common mechanisms may provide insight in the organismal level of adaptation and suggest solutions to important problems related to the adaptatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93634d1571a7faaef35a05658ff2b9f0
https://europepmc.org/articles/PMC2269004/
https://europepmc.org/articles/PMC2269004/
Autor:
I P, Pogribny, T V, Prizimirska, G I, Kulik, M B, Lutsiuk, O O, Pentiuk, K P, Postovitenko, M A, Artemchuk, L A, Poirier, V F, Chekhun
Publikováno v:
Ukrains'kyi biokhimichnyi zhurnal (1999 ). 77(4)
In the present study we determined the age-related effect of methionine-enriched diet, a model of hyperhomocysteinemia, on the level of plasma homocysteine and hepatic global DNA methylation in rats. Feeding methionine diet to middle-aged rats for on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6246ddcde47be7ec422e84042ae10db0
https://pubmed.ncbi.nlm.nih.gov/16568612
https://pubmed.ncbi.nlm.nih.gov/16568612
Publikováno v:
Cancer research. 60(3)
It is not known whether transcriptional suppression by de novo methylation occurs within the promoter region of the p53 gene during multistage tumorigenesis. To address this question, in vivo alterations in the CpG methylation within the rat p53 prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6387ada15de269b9474cee09e0365f1
https://pubmed.ncbi.nlm.nih.gov/10676641
https://pubmed.ncbi.nlm.nih.gov/10676641
Publikováno v:
The American journal of pathology. 149(4)
Folate deficiency enhances colorectal carcinogenesis in dimethylhydrazine-treated rats. Folate is an important mediator of DNA methylation, an epigenetic modification of DNA that is known to be dysregulated in the early stages of colorectal cancer. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86dd1a22d021fab95716bb1007e991e5
https://pubmed.ncbi.nlm.nih.gov/8863662
https://pubmed.ncbi.nlm.nih.gov/8863662
Publikováno v:
Cancer research. 55(9)
Male weanling Fischer 344 rats were fed either a semipurified diet deficient in the methyl donors methionine, choline, and folic acid or a supplemented control diet for a period of 9 weeks. At intervals of 2, 5, and 7 days, 3 weeks, and 9 weeks after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e1a7d06fbaed0b055564bed1e190b03
https://pubmed.ncbi.nlm.nih.gov/7794383
https://pubmed.ncbi.nlm.nih.gov/7794383