Zobrazeno 1 - 10
of 22
pro vyhledávání: '"I. P. Mulligan"'
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 442:171-177
The effect of the cardiotonic sensitizing drug EMD 57033 was studied in frog skinned skeletal muscle fibres at 12 degrees C to provide a baseline for skeletal muscle studies and for comparison with cardiac fibres. The activation and relaxation of fib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3924e00f2e52dd1b8de8d6319d828bc6
https://doi.org/10.1007/s004240000500
https://doi.org/10.1007/s004240000500
Publikováno v:
Biochemical and Biophysical Research Communications. 254:330-333
When free calcium is rapidly removed from skinned fibres using the photolabile Ca2+ chelator diazo-2, they relax without an appreciable change in sarcomere length (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f265ce4f398d12697f9539c9966d97
https://doi.org/10.1006/bbrc.1998.9879
https://doi.org/10.1006/bbrc.1998.9879
Publikováno v:
Heart. 71:268-273
OBJECTIVE--To study QT dispersion in left ventricular hypertrophy and chronic heart failure and to determine the relation to ventricular arrhythmias. SETTING--Investigational laboratory of a tertiary referral centre. STUDY DESIGN--Patients with left
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fc6bf33418aa629a868d139f30ec79
https://doi.org/10.1136/hrt.71.3.268
https://doi.org/10.1136/hrt.71.3.268
Autor:
Laura C. Preston, I. P. Mulligan, C Redwood, Paul Robinson, Christopher C. Ashley, S. Lipscomb
Publikováno v:
The Biochemical journal. 388(Pt 3)
The effects of the cardiotonic potentiator EMD 57033 on different TnC (troponin C) isoforms were investigated. Endogenous skeletal TnC was extracted from glycerinated, permeabilized rabbit psoas fibres and replaced with either purified native rabbit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5533dc2ece9c29995bd1be32584b95
http://ora.ox.ac.uk/objects/uuid:c0528d43-8c5c-43d1-8498-e3cc74daaf4c
http://ora.ox.ac.uk/objects/uuid:c0528d43-8c5c-43d1-8498-e3cc74daaf4c
Publikováno v:
Pflugers Archiv : European journal of physiology. 437(3)
The effect of phosphate on the relaxation of isometrically contracting single skinned fibres from the semitendinosus muscle of the frog Rana temporaria has been investigated using laser pulse photolysis of the photolabile caged calcium-chelator diazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ba4cf8f396c63a352edfb6a9a47d6c
https://pubmed.ncbi.nlm.nih.gov/9914395
https://pubmed.ncbi.nlm.nih.gov/9914395
Autor:
I. P. Mulligan, Elizabeth A.M. Hodson, H. Thurston, E. C. Johns, Joanne S Lymn, H. Fish, Christopher C. Ashley
Publikováno v:
Pflugers Archiv : European journal of physiology. 436(1)
Rat models of cardiac hypertrophy are characterised by a shift in left ventricular myosin isoform from V1 (adult) to V3 (foetal), the latter being associated with a slowing of the acto-myosin ATPase rate. The aim of this study was to examine hypertro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6123462e781076683d4b6cf064cb47c9
https://pubmed.ncbi.nlm.nih.gov/9560460
https://pubmed.ncbi.nlm.nih.gov/9560460
Publikováno v:
Pflugers Archiv : European journal of physiology. 433(6)
In vivo, two effects of beta-adrenergic stimulation in cardiac muscle are phosphorylation of troponin I and an increase in relaxation rate. In vitro, cardiac TnI can be phosphorylated by protein kinase A (PKA). We have used the technique of laser fla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d549e6e5d77f42364f3bee18d6e10871
https://pubmed.ncbi.nlm.nih.gov/9049178
https://pubmed.ncbi.nlm.nih.gov/9049178
Publikováno v:
Pflugers Archiv : European journal of physiology. 425(1-2)
EMD 57033 is thought to produce its potentiating effect by increasing the apparent calcium sensitivity of myofibrils. We have investigated the effect of 10 microM EMD 57033 on relaxation speed, induced by flash photolysis of 2mM diazo-2 (a caged Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4de128c68d298cca96d7750af71be3a
https://pubmed.ncbi.nlm.nih.gov/8272375
https://pubmed.ncbi.nlm.nih.gov/8272375
Publikováno v:
Mechanism of Myofilament Sliding in Muscle Contraction ISBN: 9781461362456
The effect of Ca2+ on the time course of force generation in frog skinned muscle fibres has been investigated using laser flash photolysis of the caged-calcium, either nitr-5 or DM-Nitrophen. Gradations in the rate and extent of contraction could be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::280ea5352b8914c979a0ca19ef6b8550
https://doi.org/10.1007/978-1-4615-2872-2_9
https://doi.org/10.1007/978-1-4615-2872-2_9
Autor:
S. J. Simnett, I. P. Mulligan, Paul J. Pearson, C. C. Ashley, László Dux, Paul M. Vanhoutte, R. E. Palmer, T. J. Lea, P. J. Griffiths
Publikováno v:
Reviews of Physiology, Biochemistry and Pharmacology ISBN: 9783540563808
Reviews of Physiology, Biochemistry and Pharmacology, Volume 122
Reviews of Physiology, Biochemistry and Pharmacology, Volume 122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e472d6e6ff1e278cce4f010332188c1c
https://doi.org/10.1007/bfb0035272
https://doi.org/10.1007/bfb0035272