Zobrazeno 1 - 10
of 496
pro vyhledávání: '"I. Nissen"'
Autor:
Marina Crespo-Bravo, Jeppe Thorlacius-Ussing, Neel I. Nissen, Rasmus S. Pedersen, Mogens K. Boisen, Maria Liljefors, Astrid Z. Johansen, Julia S. Johansen, Morten A. Karsdal, Nicholas Willumsen
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Collagens are the major components of the extracellular matrix (ECM) and are known to contribute to tumor progression and metastasis. There are 28 different types of collagens each with unique functions in maintaining tissue struc
Externí odkaz:
https://doaj.org/article/8e62a07ff1ff43e4a58ac916255a431b
Autor:
Neel I. Nissen, Astrid Z. Johansen, Inna M. Chen, Christina Jensen, Emilie A. Madsen, Carsten P. Hansen, Jeppe Thorlacius-Ussing, Morten Karsdal, Julia S. Johansen, Hadi M. H. Diab, Lars N. Jørgensen, Nicholas Willumsen
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a pronounced fibrotic tumor microenvironment, which impairs treatment response. Type I and V collagens are responsible for the densely packed fibrils in the tumor fibrosis envi
Externí odkaz:
https://doaj.org/article/8f4be5d66b1d42658607a755ed58cc35
Autor:
Christina Jensen, Neel I. Nissen, Claus S. Von Arenstorff, Morten A. Karsdal, Nicholas Willumsen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-11 (2021)
Abstract Despite the overall clinical success of immune checkpoint inhibitors (ICIs) for treating patients with solid tumors, a large number of patients do not benefit from this approach. Consequently, there is a need for predictive biomarkers. The m
Externí odkaz:
https://doaj.org/article/4a90731714c645489f05bc2af58b49ca
Autor:
Neel I. Nissen, Stephanie Kehlet, Mogens K. Boisen, Maria Liljefors, Christina Jensen, Astrid Z. Johansen, Julia S. Johansen, Janine T. Erler, Morten Karsdal, Joachim H. Mortensen, Anette Høye, Nicholas Willumsen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract A desmoplastic colorectal cancer stroma, characterized by excess turnover of the cancer-associated fibroblast derived collagens type III and VI, can lead to reduced drug-uptake and poor treatment response. We investigated the association bet
Externí odkaz:
https://doaj.org/article/6976c8000d604bf1872674bfffb96a35
Autor:
Emilie A. Madsen, Jeppe Thorlacius-Ussing, Neel I. Nissen, Christina Jensen, Inna M. Chen, Julia S. Johansen, Hadi M. H. Diab, Lars N. Jørgensen, Carsten P. Hansen, Morten A. Karsdal, Nicholas Willumsen
Publikováno v:
Cells, Vol 11, Iss 23, p 3763 (2022)
Circulating fragments of type III collagen, measured by PRO-C3, has shown promising results as a tumor fibrosis biomarker. However, the fibrotic tumor microenvironment consists of many other collagens with diverse functions and unexplored biomarker p
Externí odkaz:
https://doaj.org/article/46a77022ccbd47e297ef2d33349a1417
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-12 (2019)
Abstract The extracellular matrix (ECM) plays an important role in cancer progression. It can be divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior and the interstitial matrix (IM) that supports the underlying
Externí odkaz:
https://doaj.org/article/9dc3f17b13d54d7ca3994775e22716af
Autor:
Rasmus S. Pedersen, Neel I. Nissen, Christina Jensen, Jeppe Thorlacius-Ussing, Tina Manon-Jensen, Majken L. Olesen, Lasse L. Langholm, Hadi M. H. Diab, Lars N. Jorgensen, Carsten P. Hansen, Inna M. Chen, Julia S. Johansen, Morten A. Karsdal, Nicholas Willumsen
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1315 (2022)
Pancreatic ductal adenocarcinoma (PDAC) is a hard-to-treat cancer due to the collagen-rich (fibrotic) and immune-suppressed microenvironment. A major driver of this phenomenon is transforming growth factor beta (TGF-β). TGF-β is produced in an inac
Externí odkaz:
https://doaj.org/article/090d7e20b41848078ab5b37623004dd1
Akademický článek
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Akademický článek
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Autor:
Neel I Nissen, Kristin R Anderson, Huaixing Wang, Hui Sun Lee, Carly Garrison, Samantha A Eichelberger, Kasarah Ackerman, Wonpil Im, Julie M Miwa
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199643 (2018)
Neuronal nicotinic acetylcholine receptors (nAChRs) of the cholinergic system have been linked to antinociception, and therefore could be an alternative target for pain alleviation. nAChR activity has been shown to be regulated by the nicotinic modul
Externí odkaz:
https://doaj.org/article/4b3fe94746154c2baf995650decb47f4