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Autor:
Menard, Delphine, Niculescu Duvaz Ion, Dijkstra, Harmen P, I. Niculescu Duvaz, Dan, Suijkerbuijk, Bart M. J. M., Zambon, Alfonso, Nourry, Arnaud, Roman, Esteban, Davies, Lawrence, Marine, Friedlos, Frank, And, Helen A., Kirk, Ruth and, Gill, Adrian, Whittaker, Steven, Taylor, Richard D, Marais, Richard, Springer, Caroline
Publikováno v:
Journal of Medicinal Chemistry. 52:3881-3891
BRAF, a serine/threonine specific protein kinase that is part of the MAPK pathway and acts as a downstream effector of RAS, is a potential therapeutic target in melanoma. We have developed a series of small-molecule BRAF inhibitors based on a 1H-imid