Zobrazeno 1 - 10
of 41
pro vyhledávání: '"I. Neb"'
Autor:
H. Lahm, S. Stieglbauer, I. Neb, S. Doppler, S. Schneider, E. Dzilic, R. Lange, M. Krane, M. Dreßen
Publikováno v:
Stem Cell Research, Vol 69, Iss , Pp 103123- (2023)
TBX5 is a transcription factor (TF) playing essential role during cardiogenesis. It is well known that TF mutations possibly result in non- or additional binding of the DNA due to conformational changes of the protein. We introduced a Holt-Oram Syndr
Externí odkaz:
https://doaj.org/article/bf497e1002d643ad87ee174d5949db35
Autor:
H. Lahm, S. Stieglbauer, I. Neb, S.A. Doppler, S. Schneider, E. Dzilic, R. Lange, M. Krane, M. Dreßen
Publikováno v:
Stem Cell Research, Vol 66, Iss , Pp 103011- (2023)
Although TBX5 plays a major role during human cardiogenesis and initiates and controls limb development, many of its interactions with genomic DNA and the resulting biological consequences are not well known. Existing anti-TBX5-antibodies work very i
Externí odkaz:
https://doaj.org/article/e8ef70d834a844e8b99599610cd867c9
Autor:
M. Dreßen, T. Luzius, H. Lahm, I. Neb, S.A. Doppler, S. Schneider, E. Dzilic, R. Lange, M. Krane
Publikováno v:
Stem Cell Research, Vol 59, Iss , Pp 102662- (2022)
We generated an induced pluripotent stem cell (iPSC) line from a healthy male 29-year-old proband. Adipose fibroblasts (AFs) were reprogrammed using Sendai virus. Generated iPSCs showed typical stem cell morphology. From passage 9 on, iPSCs were free
Externí odkaz:
https://doaj.org/article/b47f3314feee4cf3b95e30a13253baff
Autor:
M. Dreßen, H. Lahm, I. Neb, T. Luzius, S.A. Doppler, S. Schneider, E. Dzilic, R. Lange, M. Krane
Publikováno v:
Stem Cell Research, Vol 58, Iss , Pp 102617- (2022)
The Holt-Oram syndrome (HOS) is a rare autosomal dominant disorder, mostly based on mutations in the TBX5 gene. Patients show malformation of at least one upper limb along with congenital heart defects. The established induced pluripotent stem cell (
Externí odkaz:
https://doaj.org/article/381eafa5ea6e4b4ebde63548d2bd41e8
Publikováno v:
The Thoracic and Cardiovascular Surgeon.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1dc33ce8b501b1567c617b64b2e274c
https://doi.org/10.1055/s-0043-1761827
https://doi.org/10.1055/s-0043-1761827
Autor:
H. Lahm, S. Stieglbauer, I. Neb, S.A. Doppler, S. Schneider, E. Dzilic, R. Lange, M. Krane, M. Dreßen
Publikováno v:
Stem cell research. 66
Although TBX5 plays a major role during human cardiogenesis and initiates and controls limb development, many of its interactions with genomic DNA and the resulting biological consequences are not well known. Existing anti-TBX5-antibodies work very i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46f55bbd1220723dc99ffa8e1efef35
https://pubmed.ncbi.nlm.nih.gov/36610218
https://pubmed.ncbi.nlm.nih.gov/36610218
Autor:
Konstantinos Sideris, Lena Eschenbach, Harald Lahm, Marcus-André Deutsch, N. Beck, Karl C. König, Isabel Deisenhofer, Rüdiger Lange, Matthias Mann, Stefanie A. Doppler, Nazan Puluca, Stefanie Voss, Shunsuke Matsushima, Sophia Doll, Markus Krane, M. Dreßen, I. Neb, Stefan Holdenrieder
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Lahm, H, Dressen, M, Beck, N, Doppler, S, Deutsch, M-A, Matsushima, S, Neb, I, Koenig, K C, Sideris, K, Voss, S, Eschenbach, L, Puluca, N, Deisenhofer, I, Doll, S, Holdenrieder, S, Mann, M, Lange, R & Krane, M 2019, ' Myosin binding protein H-like (MYBPHL) : a promising biomarker to predict atrial damage ', Scientific Reports, vol. 9, 9986 . https://doi.org/10.1038/s41598-019-46123-w
Scientific Reports
Lahm, H, Dressen, M, Beck, N, Doppler, S, Deutsch, M-A, Matsushima, S, Neb, I, Koenig, K C, Sideris, K, Voss, S, Eschenbach, L, Puluca, N, Deisenhofer, I, Doll, S, Holdenrieder, S, Mann, M, Lange, R & Krane, M 2019, ' Myosin binding protein H-like (MYBPHL) : a promising biomarker to predict atrial damage ', Scientific Reports, vol. 9, 9986 . https://doi.org/10.1038/s41598-019-46123-w
Myosin binding protein H-like (MYBPHL) is a protein associated with myofilament structures in atrial tissue. The protein exists in two isoforms that share an identical amino acid sequence except for a deletion of 23 amino acids in isoform 2. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cceae01261db4763678e6b81b1a57c
http://link.springer.com/article/10.1038/s41598-019-46123-w
http://link.springer.com/article/10.1038/s41598-019-46123-w
Autor:
Stefanie Sudhop, Harald Lahm, Thomas Brade, Sharon L. Paige, Alexander Goedel, Svenja Laue, Thomas Meitinger, Markus Krane, Stefanie A. Doppler, Alessandra Moretti, Connie R. Bezzina, Pedro Schneider, Zhong Zhang, Makoto Sahara, Neil E. Bowles, Hilansi Rawat, Riccardo Berutti, Nazan Puluca, Ilaria My, Peter J. Gruber, Andreas Dendorfer, Ralf Gilsbach, Nora Lang, M. Dreßen, Christine M. Schneider, S. Schwarz, Daniel Sinnecker, I. Neb, Gianluca Santamaria, Karl-Ludwig Laugwitz, Rüdiger Lange, Sean M. Wu, Bruce D. Gelb, C. Abou-Ajram, Tatjana Dorn, Fleur V.Y. Tjong, Lia Crotti, Maria Rijlaarsdam, Matthias Mann, Christian Kupatt, Lutz Hein, Julie Cleuziou, Elisa Mastantuono, Lesca M. Holdt, Sophia Doll, Bernd H. Northoff
Publikováno v:
Circulation 144, 1409-1428 (2021)
Circulation
bioRxiv
Circulation, 144(17), 1409-1428. Lippincott Williams and Wilkins
Circulation
bioRxiv
Circulation, 144(17), 1409-1428. Lippincott Williams and Wilkins
Supplemental Digital Content is available in the text.
Background: Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left heart syndrome (HLHS) is the most common and severe manifestation within the
Background: Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left heart syndrome (HLHS) is the most common and severe manifestation within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0de69ffa304c5f2a963a861f6f795c
https://doi.org/10.1101/2021.04.24.441110
https://doi.org/10.1101/2021.04.24.441110
Autor:
Harald Lahm, Julie Cleuziou, Markus Krane, I. Neb, James R. Priest, Felix Wirth, Melchior Burri, Peter Lichtner, N. Beck, Elda Dzilic, Johannes A Ziegelmüller, Thomas Meitinger, Zhong Zhang, Bertram Müller-Myhsok, Ralf Gilsbach, Peter Ewert, Olga Bondareva, Stefanie A. Doppler, Bernard Keavney, Jürgen Hörer, Heather J. Cordell, C. Abou-Ajram, Karl C. König, Nazan Puluca, Rüdiger Lange, Gertrud Eckstein, M. Dreßen, Meiwen Jia, Lutz Hein, Elisa Mastantuono
Publikováno v:
J. Clin. Invest. 131:e141837 (2021)
J Clin Invest
J Clin Invest
Genetic factors undoubtedly affect the development of congenital heart disease (CHD) but still remain ill defined. We sought to identify genetic risk factors associated with CHD and to accomplish a functional analysis of SNP-carrying genes. We perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b92de8447f7fe27926d377db0d05287
https://doi.org/10.1172/jci141837
https://doi.org/10.1172/jci141837
Autor:
I. Neb, Thomas Meitinger, F. Wirth, Ralf Gilsbach, Bernard Keavney, Priest, P. Lichtner, P. Ewert, J.A. Ziegelmüller, N. Beck, C. Abou-Ajram, Melchior Burri, Zhong Zhang, Ruediger Lange, Bertram Müller-Myhsok, Julie Cleuziou, G. Eckstein, Harald Lahm, Nazan Puluca, Stefanie A. Doppler, Olga Bondareva, Markus Krane, König Kc, Heather J. Cordell, Meiwen Jia, Lutz Hein, Elisa Mastantuono, Jürgen Hörer, M. Dreßen, E. Dzilic
RationaleGenetic factors undoubtedly contribute to the development of congenital heart disease (CHD), but still remain mostly ill-defined.ObjectiveIdentification of genetic risk factors associated with CHD and functional analysis of SNP-carrying gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f0bea85d27555a8606a18e73ed628a6
https://doi.org/10.1101/2020.06.19.161067
https://doi.org/10.1101/2020.06.19.161067