Zobrazeno 1 - 10
of 39
pro vyhledávání: '"I. N. Crispe"'
Publikováno v:
The Journal of Immunology. 159:4261-4267
We have examined the susceptibility of mouse thymocytes and Con A-activated mature T cells to CD95 (Fas; APO-1)-induced apoptosis at different phases of the cell cycle. Signaling through CD95, induced by murine CD95 ligand expressed on fibroblasts, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::342b27c95972167cae96c4a229e4a830
https://doi.org/10.4049/jimmunol.159.9.4261
https://doi.org/10.4049/jimmunol.159.9.4261
Publikováno v:
The Journal of Experimental Medicine
The developmental arrest of thymocytes from scid mice, deficient in variable, (diversity), and joining, or V(D)J recombination, can be overcome by sublethal gamma-irradiation. Since previous studies focused on restoration of rearrangement of the T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c018fb61c27085a616d13638fff35a42
https://doi.org/10.1084/jem.184.2.419
https://doi.org/10.1084/jem.184.2.419
Publikováno v:
The Journal of Immunology. 156:4041-4049
To investigate the possibility that non-alpha beta T cell-dependent mechanisms can induce systemic autoimmune disease, and to address the roles of alpha beta T cells in murine lupus, we analyzed lupus-prone MRL mice congenitally deficient in alpha be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdebf3d9c41c0eee2b994048207abb39
https://doi.org/10.4049/jimmunol.156.10.4041
https://doi.org/10.4049/jimmunol.156.10.4041
Autor:
D. P. M. Hughes, I. N. Crispe
Publikováno v:
The Journal of Experimental Medicine
We report a soluble isoform of mouse Fas, which is generated by alternative splicing of Fas mRNA to a newly identified exon located between exons 2 and 3 of the previously published Fas sequence. This splicing event creates a novel Fas transcript, Fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad463d7c82e7f5f5fa4fa96d3f03da17
https://doi.org/10.1084/jem.182.5.1395
https://doi.org/10.1084/jem.182.5.1395
Publikováno v:
The Journal of Experimental Medicine
Fas-mediated apoptosis is essential for activation-induced cell death of alpha/beta T cells, but it is not clear what role, if any, it plays in regulating other components of the immune system. To study the role of Fas in gamma/delta T cell developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609ecc299c77fe2b7c3323edc59a5e20
https://doi.org/10.1084/jem.182.1.233
https://doi.org/10.1084/jem.182.1.233
Autor:
L Huang, I N Crispe
Publikováno v:
The Journal of Immunology. 151:1844-1851
Injection of lymphoid cells expressing minor lymphocyte-stimulating antigen-1 (Mls-1a) induces tolerance to the superantigen, and partial deletion of Mls-1a-reactive T cells. We have identified a transient population of T cells that have lost the alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5293a222afba81f0ff24e17883d31e19
https://doi.org/10.4049/jimmunol.151.4.1844
https://doi.org/10.4049/jimmunol.151.4.1844
Autor:
I. N. Crispe, L Huang
Publikováno v:
The Journal of Experimental Medicine
The T cell receptor (TCR) repertoire of CD4+ and CD8+ alpha/beta T cells is heavily influenced by positive and negative selection events that occur during T cell development in the thymus. The coreceptors CD4 and CD8 appear to be essential for this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a051a79ffe69570d4f5ffa80eb8b52
https://doi.org/10.1084/jem.176.3.699
https://doi.org/10.1084/jem.176.3.699
Autor:
I N Crispe
Publikováno v:
Current Protocols in Immunology
The liver is a distinctive immunological environment in which are found a wide variety of cell types. The absolute number of intrahepatic lymphocytes (IHL) and the frequency of the various components of the cell mixture in the liver are influenced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a251c28a0d23bd8e628b98afa5d586b
https://pubmed.ncbi.nlm.nih.gov/18432786
https://pubmed.ncbi.nlm.nih.gov/18432786
Publikováno v:
European Journal of Immunology. 20:1597-1602
The heat-stable antigen (HSA) is a marker of hematopoietic differentiation in both the B and T cell lineages. The antigen is recognized by a series of monoclonal antibodies which includes J11d, M1/69 and B2A2, and in addition YBM5.10.4. We show here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa3a17d6985aa229efbfad1bd41029e
https://doi.org/10.1002/eji.1830200728
https://doi.org/10.1002/eji.1830200728
Autor:
Y, Bae, I N, Crispe
Publikováno v:
Journal of cellular biochemistry. 80(3)
CD95 engagement results in apoptosis in thymocytes and in the Jurkat human leukemic T cell line. Biochemical analyses in CD95-engaged thymocytes and Jurkat cells revealed dysregulation of the G1/S cell cycle control point. Cyclin E was upregulated up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::237dacfebd6ad9eee35ff3c70257f409
https://pubmed.ncbi.nlm.nih.gov/11135362
https://pubmed.ncbi.nlm.nih.gov/11135362