Zobrazeno 1 - 10
of 239
pro vyhledávání: '"I. Mowszowicz"'
In the past 10 years hirsutism has been the object of a considerable number of fundamental studies. It provides endocrinologists with an experimental model for the investigation of androgen secretion, metabolism and mechanism of action. Plasma androg
Autor:
James S. Prihoda, I. Mowszowicz, Maria I. New, David W. Russell, Berenice B. Mendonca, Jean D. Wilson, W. Christian Wigley
Publikováno v:
Biochemistry. 33:1265-1270
The enzyme steroid 5 alpha-reductase utilizes NADPH to reduce the double bonds of a variety of steroid substrates with generalized 3-oxo, delta 4,5 structures. One substrate for this membrane-bound enzyme is testosterone, whose reduction to dihydrote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc441f510f24ae063e3a61462dca978
https://doi.org/10.1021/bi00171a029
https://doi.org/10.1021/bi00171a029
Autor:
I. Mowszowicz
Publikováno v:
Molecular Endocrinology. 7:861-869
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85c9017545f5e326ad9ea5ee4274a808
https://doi.org/10.1210/me.7.7.861
https://doi.org/10.1210/me.7.7.861
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 73:1008-1015
Beside the well characterized PRL-secreting adenomas, a wide spectrum of functional hyperprolactinemic states exists. We describe here five women, 21-38 yr old, all suspected of having a PRL-secreting adenoma because of a pseudotumoral appearance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9e2af8534b15176d74daab29bf0412
https://doi.org/10.1210/jcem-73-5-1008
https://doi.org/10.1210/jcem-73-5-1008
Publikováno v:
The Prostate. 56(3)
In prostate cancer cell lines, androgen receptor (AR) coactivators modulate the transcriptional activity of AR. However, very little is known about their expression in normal prostate tissue and during progression to cancer.AR and coactivators ARA54,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::883760901741fdf3052bc6365103882e
https://pubmed.ncbi.nlm.nih.gov/12772188
https://pubmed.ncbi.nlm.nih.gov/12772188
Publikováno v:
The Prostate. 46(4)
Stromal-epithelial interactions play a critical role in prostate development, but the precise mechanisms are still unknown. Transforming growth factor-beta (TGFbeta) could be a potential mediator of these interactions, but there is as yet no clear de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc0fde6c31f82b0b45ffa9c0e6b880b2
https://pubmed.ncbi.nlm.nih.gov/11241554
https://pubmed.ncbi.nlm.nih.gov/11241554
Publikováno v:
The Prostate. 32(3)
Whereas the embryological development of the human prostate is clearly dependent on steroid 5 alpha-reductase (5 alpha-R) type 2 expression, the respective expression of the two known isoforms (types 1 and 2) of 5 alpha-R in the adult human prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::008ff4aa4c27c8b53629d5e3da7bffff
https://pubmed.ncbi.nlm.nih.gov/9254894
https://pubmed.ncbi.nlm.nih.gov/9254894
Autor:
I, Mowszowicz, C, Mestayer
Publikováno v:
Bulletin du cancer. 84(2)
Prostate cancer is the second most frequent cancer in men, and the first after 75 years of age. It is androgen dependent and modifications of the androgen receptor (AR) could therefore be involved in its apparition, progression and evolution towards
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0651d7fcc05a1897b3cee3363c9ea50f
https://pubmed.ncbi.nlm.nih.gov/9180843
https://pubmed.ncbi.nlm.nih.gov/9180843
Publikováno v:
Annales d'endocrinologie. 56(6)
In most androgen target tissues, the first step of androgen action is the 5 alpha-reduction of testosterone to DHT which binds to the androgen receptor with an affinity 3 to 4 fold higher than testosterone. Two genes, encoding two isozymes of 5 alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8a75b29c9785d0790998a046f68ccd3
https://pubmed.ncbi.nlm.nih.gov/8787343
https://pubmed.ncbi.nlm.nih.gov/8787343
Autor:
I, Mowszowicz, F, Kuttenn
Publikováno v:
La Revue du praticien. 44(10)
Androgen insensitivity syndromes are suspected in XY subjects with normal testosterone secretion presenting with absent or severely impaired androgen dependent sexual differentiation. Such clinical features suggest an abnormality of the androgen rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24354d5a7f0be931afc238ea59161dfc
https://pubmed.ncbi.nlm.nih.gov/7939189
https://pubmed.ncbi.nlm.nih.gov/7939189