Zobrazeno 1 - 10
of 60
pro vyhledávání: '"I. Midgley"'
Publikováno v:
Food and Chemical Toxicology. 30:57-64
The percutaneous absorption has been investigated in rats of a mixture (3:2, w/w) of N-methyl-2-pyrrolidinone (NMP) and 2-pyrrolidinone (2-P), a combination intended for use as a vehicle in the formulation of an antimycotic drug to enhance skin penet
Publikováno v:
Xenobiotica. 13:87-95
1. Concentrations of unchanged drug and patterns of radioactive components in urine have been determined by h.p.l.c. following single oral doses of [14C]lofexidine hydrochloride (0.32 mg) to six human subjects. 2. A mean of 12% of the administered do
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 15:511-521
The syntheses of the antidepressant drug, amitriptyline, and its metabolites nortriptyline and desmethylnortriptyline, doubly labelled with carbon-13 have been accomplished in thirteen stages. Ba13CO3 was used for the carbonation of o-tolylmagnesium
Autor:
D. R. Hawkins, I. Midgley
Publikováno v:
Journal of Labelled Compounds. 10:663-670
The syntheses of 1-m-trifluoromethylphenyl-2-N-ethylaminopropane (I; Ponderax®) and 1-m-trifluoromethylphenyl-2-N-β-benzoyloxyethylaminopropane (II; S780) labelled with carbon-14 at the benzylic position have been accomplished in seven stages start
Autor:
P.J. van Bladeren, R. R. Brodie, D. R. Hawkins, L. M. Walmsley, Chasseaud Lf, I Midgley, A. Darragh
Publikováno v:
Xenobiotica. 11:595-608
1. Following single oral doses of 3[H]econazole base (500 mg) to two human subjects, excretion of radioactivity was prolonged, and incomplete after five days (means of 40% and 27% dose in urine and faeces respectively). 2. Plasma concn. of unchanged
Publikováno v:
Steroids. 41:521-536
After intramuscular administration of 16 beta-ethyl-17 beta-hydroxy-4-4-[4-14C]estren-3-one (14C-oxendolone; 300 mg) to 3 human subjects, excretion of 14C was very slow and incomplete despite a 20-day sample collection period. During this time, means
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 8:109-116
Concentrations of total radioactivity, unchanged econazole, and extractable metabolites in plasma, and chromatographic patterns of radioactive components in urine, have been determined after single oral doses of [3H]-econazole nitrate to nonpregnant
Publikováno v:
Journal of Pharmacy and Pharmacology. 34:299-303
The major urine metabolites of the neuroleptic drug, bromperidol, after oral doses to rats and dogs are p-fluorophenylacetic acid and its glycine conjugate resulting from oxidative N-dealkylation. While the same metabolites were also detected in huma
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 7(4)
A high-performance liquid chromatographic method for the routine, simultaneous determination of amitriptyline and its basic metabolites in human urine has been developed. 10-Hydroxylated metabolites are analyzed as their 10,11-dehydro analogs, and pr
Autor:
L. M. Walmsley, I Midgley, A. G. Fowkes, L. F. Chasseaud, R. Bonn, R F Lambe, I. W. Taylor, A. Darragh
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 15(11)
The metabolic fate of [14C]ryosidine (ryodipine) has been investigated after oral administration to human subjects (by capsule), and to rats and dogs (in solution). The excretion patterns of 14C were similar for all three species: about 50% dose was