Zobrazeno 1 - 10
of 90
pro vyhledávání: '"I. M. Shapiro"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The central region of the intervertebral disc (IVD) is rich in proteoglycans, leading to a hyperosmotic environment, which fluctuates with daily loading. The cells of the nucleus pulposus (NP cells) have adapted to this environment via the f
Externí odkaz:
https://doaj.org/article/4138b596e4be471abac6b99852763239
Autor:
T. V. Brezhneva, V. S. Gaitskhoki, V. F. Semiglasov, B. M. Lipovetsky, E. P. Lamber, K. P. Hanson, V. I. Golubkov, M.Ju. Mandelshtam, I. M. Shapiro
Publikováno v:
Russian Journal of Genetics. 37:1415-1420
DNA of oncological patients, including Ashkenazi Jews and Slavs, living in St. Petersburg was collected, and the resultant collection was screened for three common mutations of genes BRCA1andBRCA2by means of heteroduplex analysis. The mutation 5382in
Publikováno v:
Immunopharmacology and Immunotoxicology. 15:273-290
The major goal of this investigation was to determine if the sensitivity of lymphocytes and monocytes to mercury (Hg++) was related to intracellular glutathione (GSH) levels and the thiol redox status [GSH/glutathione disulfide (GSSG)]. To isolate ce
Publikováno v:
Immunopharmacology and Immunotoxicology. 14:555-577
The major goal of this investigation was to examine the cytotoxic properties of both HgCl2 and MeHgCl, in terms of their ability to alter human T-cell and monocyte viability. Following treatment with HgCl2 (0-20 micrograms/ml) or MeHgCl (0-2 microgra
Autor:
M V, Risbud, I M, Shapiro
Publikováno v:
Orthodonticscraniofacial research. 8(2)
Mesenchymal stem cells (MSC) have been identified in a variety of adult tissues as a population of pluripotential self-renewing cells. Based on their adherence and colony forming properties, a small number of MSC can be isolated from most mesenchymal
Autor:
C S, Adams, I M, Shapiro
Publikováno v:
Connective tissue research. 44
Bone cell apoptosis is seen at sites of active turnover. We hypothesize that at these sites, factors released from resorbing bone induce apoptosis of vicinal cells. Related to this observation, earlier studies indicate that an elevation in the level
Publikováno v:
Global Spine Journal. 4:s-0034
Introduction Objective To investigate TGFβ regulation of galectin-3 expression in nucleus pulposus (NP) cells and its role in degenerative disc disease. Materials and Methods qRT-PCR and Western blot were used to measure galectin-3 expression in NP.
Publikováno v:
The Journal of biological chemistry. 276(23)
Previously, we noted that inorganic phosphate (P(i)), a major component of bone extracellular matrix, induced osteoblast apoptosis (Meleti, Z., Shapiro, I. M., and Adams, C. S. (2000) Bone (NY) 27, 359-366). Since Ca(2+) along with P(i) is released f
Publikováno v:
Journal of biomedical materials research. 52(4)
The objective of this study was to determine the effect of porous bioactive glass (45S5) substrate characteristics on the expression and maintenance of the osteoblastic phenotype. We cultured ROS 17/2. 8 cells on substrates with different pore size a
Publikováno v:
Journal of biomedical materials research. 51(4)
The objective of the study was to investigate the capability of bioactive glass 45S5 to serve as a substrate for nucleus pulposus cells in vitro. Nucleus pulposus cells were isolated from adult rabbit discs and seeded onto bioactive glass. At selecte