Zobrazeno 1 - 10
of 18
pro vyhledávání: '"I. M. Molotkovskaya"'
Autor:
T. K. Aliev, A. A. Zubareva, R. V. Kholodenko, M. V. Larina, I. V. Kholodenko, Anna A Boyko, Igor Doronin, F. N. Rozov, Polina Vishnyakova, I. M. Molotkovskaya
Publikováno v:
Russian Journal of Bioorganic Chemistry. 42:532-545
Methodological approaches to the creation of nanoparticles based on chitosan derivatives and targeted to the GD2-positive tumor cells were developed. The GD2-specific monoclonal antibodies and their Fab-fragments and scFv-fragments were obtained and
Autor:
I. M. Molotkovskaya, Oleg V. Batishchev, Liudmila A. Shilova, V. V. Aleksandrova, Sergey A. Akimov, Timur R. Galimzyanov, Anna S. Lyushnyak, I. I. Mikhalyov
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 33(14)
Liquid-ordered lipid domains, also called rafts, are assumed to be important players in different cellular processes, mainly signal transduction and membrane trafficking. They are thicker than the disordered part of the membrane and are thought to fo
Autor:
I. M. Molotkovskaya, I. V. Kholodenko, D. Yu. Ryazantsev, Igor Doronin, Polina Vishnyakova, R. V. Kholodenko
Publikováno v:
Russian Journal of Bioorganic Chemistry. 40:279-287
Contribution of the main caspases in cytotoxic effects induced by the monoclonal antibody 14G2a specific to the tumor-associated ganglioside GD2 was studied in the EL-4 mouse lymphoma cells. The constitutive expression of the procaspase genes was fou
Publikováno v:
Bulletin of Experimental Biology and Medicine. 154:658-663
Monoclonal antibodies ME361 specific to ganglioside GD2 were isolated from the conditioned medium of hybridoma HB9326 and mouse ascitic fluid by the method of affinity chromatography; their Fab-fragments were obtained by proteolytic cleavage with pap
Autor:
I. I. Mikhalyov, Sergey A. Akimov, I. M. Molotkovskaya, W. G. Telford, Ivan A. Boldyrev, Pavel V. Bashkirov, E. A. Hlaponin
Publikováno v:
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 3:216-222
Gangliosides are significant participants in suppression of immune system during tumor processes. It was shown that they can induce apoptosis of T-lymphocytes in a raft-dependent manner. Fluorescence confocal microscopy was used to study distribution
Publikováno v:
Scopus-Elsevier
Ganglioside-induced apoptosis in mouse thymocytes was shown to be caspase-dependent, mitochondria being involved in the apoptosis-signaling pathway of GM1-, GD3-and GT1b-stimulated cells. According to their role in caspase-8-induced signaling cascade
Autor:
E. V. Khirova, I. M. Molotkovskaya, Elena I. Kovalenko, Alexander M. Sapozhnikov, Nicolai V. Bovin, Sergey V. Khaidukov, Marina A. Sablina, T. V. Ovchinnikova
Publikováno v:
Russian Journal of Bioorganic Chemistry. 30:250-260
An experimental model system involving the modification of carbohydrate composition of the target cell surface with neoglycolipids was developed for studying the role of surface carbohydrates of target cells in the NK-cell-mediated cytotoxicity. The
Publikováno v:
Neurochemical Research. 27:761-770
Ganglioside-induced apoptosis in the cells of IL-2–dependent cytotoxic murine cell line CTLL-2 was shown to be caspase dependent: GM1-, GM2-, and GD3-induced suppression of cell proliferation was cancelled by a general caspase inhibitor Z-VAD-FMK.
Autor:
I. M. Molotkovskaya, R. V. Kholodenko, I. V. Kholodenko, Polina Vishnyakova, Dmitry Y. Ryazantsev, Eugene D. Ponomarev, Igor Doronin
Publikováno v:
BMC Cancer
Background Ganglioside GD2 is expressed on plasma membranes of various types of malignant cells. One of the most promising approaches for cancer immunotherapy is the treatment with monoclonal antibodies recognizing tumor-associated markers such as ga
Autor:
Yu. A. Zolotarev, Georgy B. Telegin, Irina A. Kostanyan, I. M. Molotkovskaya, Elena V. Navolotskaya, M. V. Astapova, S. M. Dranitsyna, Valery M. Lipkin, Ludmila K. Baidakova, I. L. Rodionov, T. N. Lepikhova
Publikováno v:
Russian Journal of Bioorganic Chemistry. 26:450-456
Six-membered peptide fragment TGENHR (HLDF-6) was identified in the HL-60 cell culture of human promyelocyte leukemia treated with retinoic acid when studying the differentiation factor HLDF of this cell line. HLDF-6 retains the ability of the full-s