Výsledky vyhledávání - "I. M. Le-Deygen"

Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media

Autor: I. D. Grozdova, Oxana E Musatova, Nikolay S. Melik-Nubarov, Victor N. Orlov, I. M. Le-Deygen

Publikováno v: Biomacromolecules. 22:681-689

We report here the first evidence for the interaction of poly(ethylene glycol) (PEG) with hyaluronan (HA) in aqueous solutions. PEG-HA complexes (Kapp = 45,000 ± 8000 M-1) contained about 3.3 ± 0.1 of ethylene glycol units per disaccharide of HA. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aff39399ced4f59d879ef2464ae1df8
https://doi.org/10.1021/acs.biomac.0c01504

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Regulation of Properties of Lipid Membranes by Interaction with 2-Hydroxypropyl β-Cyclodextrin: Molecular Details

Autor: A. A. Skuredina, I. M. Le-Deygen, N. G. Belogurova, Anastasia S. Tychinina, Elena V. Kudryashova

Publikováno v: Russian Journal of Bioorganic Chemistry. 46:692-701

The interaction between 2-hydroxypropyl β-cyclodextrin (HPCD) and a liposomal bilayer has been studied. The main binding sites of HPCD on the surface of neutral liposomes based on dipalmitoylphosphatidylcholine (DPPC) are the phosphate groups of lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a174dde4bbb585996e894fc3da196ec
https://doi.org/10.1134/s1068162020050246

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Experimental Methods to Study the Mechanisms of Interaction of Lipid Membranes with Low-Molecular-Weight Drugs

Autor: A. A. Skuredina, Elena V. Kudryashova, I. M. Le-Deygen

Publikováno v: Russian Journal of Bioorganic Chemistry. 46:480-497

The review is devoted to methods for studying how lipid membranes interact with low-molecular-weight drugs. The following methods are considered in the review: IR and EPR spectroscopy, fluorescence analysis, differential scanning calorimetry, and mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::540480f44cb4a21d589aff170049cb65
https://doi.org/10.1134/s1068162020040123

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A Spectral Approach to Study Interaction between Chitosan Modified with Mannose and Concavalin A for the Creation of Address Delivery Systems of Antituberculosis Drugs

Autor: P. V. Mamaeva, A. A. Skuredina, I. M. Le-Deygen, Elena V. Kudryashova

Publikováno v: Moscow University Chemistry Bulletin. 75:213-217

We present a comprehensive study of the receptor–ligand interaction by spectral methods on the example of Concanavalin A lectin and 5 kDa chitosan modified with D-mannose. An improved method for the modification of chitosan with D-mannose and purif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e985c3313938b8d90cadf653efa968a
https://doi.org/10.3103/s0027131420040045

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Physical and Chemical Properties of the Guest–Host Inclusion Complexes of Cyprofloxacin with β-Cyclodextrin Derivatives

Autor: Elena V. Kudryashova, A. A. Skuredina, T. Yu. Kopnova, I. M. Le-Deygen

Publikováno v: Moscow University Chemistry Bulletin. 75:218-224

We study the effect of the nature of the substituent in the β-cyclodextrin derivative on the physicochemical properties of the antibacterial drug ciprofloxacin (CF). CF can form guest–host inclusion complexes with β-cyclodextrin derivatives, char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da8e6b836b8eff7c1e996348773988c9
https://doi.org/10.3103/s0027131420040069

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Magnetic Liposomes for Remote Controlled High-Molecular Drugs Release under a Low-Frequency Non-Heating Magnetic Field

Autor: A. V. Petrunin, Natalia L. Klyachko, I. M. Le-Deygen, Alexander V. Kabanov, A. N. Prusov, S. Ch. Vanzarakshaeva, K. Yu. Vlasova, M. M. Veselov, Yu. I. Golovin, A. B. Shuklinov

Publikováno v: Moscow University Chemistry Bulletin. 75:232-237

Magnetic anionic liposomes (MALip) conjugated with magnetite magnetic nanoparticles (MNPs) are developed for the controlled release of a protease inhibitor (BBI) under exposure to a low-frequency nonheating magnetic field (LF AMF). It is shown that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f04e84593e1fc26d26ce0ae5cb0d4b5a
https://doi.org/10.3103/s0027131420040112

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Influence of Physicochemical Properties of Fluoroquinolones on their Interaction with Human Serum Albumin

Autor: L.R. Yakupova, T.Y. Kopnova, I. M. Le-Deygen, Elena V. Kudryashova

Publikováno v: Biotekhnologiya. 36:149-154

It has been shown on the example of ciprofloxacin and levofloxacin that fluoroquinolones are able to interact with human serum albumin even at low molar ratios. A fivefold molar excess of fluoroquinolone quenched the protein fluorescence until its co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b647404e3730e894ebb9ea11ad767040
https://doi.org/10.21519/0234-2758-2020-36-6-149-154

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The Influence of Lipid Matrix Composition on the Microenvironment of Levofloxacin in Liposomal Forms

Autor: I. M. Le-Deygen, A. S. Safronova, I. M. Kolmogorov, A. A. Skuredina, E. V. Kudryashova

Publikováno v: Russian journal of bioorganic chemistry. 48(4)

We have studied the interaction of the antibacterial drug levofloxacin with lipid bilayers of various compositions: 100% DPPC and with the addition of 20% cardiolipin. For DPPC liposomes, levofloxacin was found to penetrate into the subpolar region a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f341ccdf4e810e158ae544815093b5a
https://pubmed.ncbi.nlm.nih.gov/36119964

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