Zobrazeno 1 - 5
of 5
pro vyhledávání: '"I. M. Buck"'
Autor:
Tracey Cooke, I. M. Buck, Laurence Wright, Atul Kotecha, S. Barret Kalindjian, Nigel P Shankley, Julia R Cushnir, Michael John Pether, C. M. R. Low, J G Vinter
Publikováno v:
Journal of Medicinal Chemistry. 48:6790-6802
A new molecular modeling approach has been used to derive a pharmacophore of the potent and selective cholecystokinin-2 (CCK(2)) receptor antagonist 5 (JB93182), based on features shared with two related series. The technique uses "field points" as s
Autor:
Jeremy G. Vinter, I. M. Mcdonald, Sarkis Barret Kalindjian, Caroline M. R. Low, I. M. Buck, David John Dunstone, Jonathan Michael Richard Davies, Michael John Pether, Martin L. Hudson, Tozer Matthew John, Katherine Isobel Mary Steel
Publikováno v:
Journal of Medicinal Chemistry. 39:1806-1815
A series of potent and selective cholecystokinin-B/gastrin receptor antagonists based on the dibenzobicyclo[2.2.2]octane (BCO) skeleton which have recently been described were found to show species-dependent behavior when examined in rat and dog mode
Autor:
I. M. Buck, D. J. Dunstone, M. J. Pether, Sarkis Barret Kalindjian, Trushar Adatia, John Spencer, Alan Bashall, Elaine Anne Harper, C. Austin, I. M. Mcdonald, Caroline M. R. Low, Eric P. Griffin, Ian D. Linney, P. T. Wright, R. A. D. Hull
Publikováno v:
Journal of medicinal chemistry. 49(7)
A series of 1,3,4-benzotriazepine-based CCK(2) antagonists have been devised by consideration of the structural features that govern CCK receptor affinity and the receptor subtype selectivity of 1,4-benzodiazepine-based CCK(2) antagonists. In contras
Autor:
C. M. R. Low, Katherine Isobel Mary Steel, I. M. Buck, David John Dunstone, I. M. Mcdonald, Michael J. Bodkin, Michael John Pether, Sarkis Barret Kalindjian
Publikováno v:
Journal of Medicinal Chemistry. 37:3671-3673
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