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Antibody reactivity with new antigens revealed in multi-transgenic triple knockout pigs may cause early loss of pig kidneys in baboons

Autor: Yuichi Ariyoshi, Kazuhiko Yamada, Akira Shimizu, Dilrukshi K. Ekanayake‐Alper, David H. Sachs, Megan Sykes, Lennan Boyd, J. Scott Arn, Arsenoi Asfour, Ermance Estime, Thomas Pomposelli, Kazuhiro Takeuchi, David Ayares, Mayu Ohta, Marc I Lorber

Publikováno v: Xenotransplantation

BACKGROUND: Recent advances in gene editing technology have enabled the production of multi-knockout (KO) and transgenic pigs in order to overcome immunologic barriers in xenotransplantation (XTx). However, the genetic manipulations required to produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7929305c7e5b0f689f54c892953d388
https://europepmc.org/articles/PMC8957702/

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The role of industry in advancing xenotransplantation

Autor: Jordan T Shin, Martine A Rothblatt, Marc I. Lorber

Publikováno v: Current opinion in organ transplantation. 24(5)

Purpose of review Xenotransplantation offers the opportunity to alleviate the imbalance between the demand of patients with end stage organ failure and the supply of organs available for transplantation but remains aspirational. This review highlight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318e3001bf61cd453ac997bf09ccb55f
https://pubmed.ncbi.nlm.nih.gov/31385887

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Intra-bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to60 days and promotes increased porcine lung transplant survival

Autor: David Ayares, Yuichi Ariyoshi, Megan Sykes, Hisashi Sahara, Kazuhiko Yamada, Kazuhiro Takeuchi, Scott Arn, Lennan K Boyd, Thomas Pomposelli, Dilrukshi Ekanayake-Alper, Hironosuke Watanabe, Akira Shimizu, David H. Sachs, Marc I Lorber

Publikováno v: Xenotransplantation

Background We have recently demonstrated that human-CD47 (hCD47) expressed on endothelial cells of porcine lung xenografts extended median graft survival from 3.5 days to 8.7 days in baboons. Intra-bone bone marrow transplantation (IBBMTx) in a pig-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ade2dc04f04150aba276aa6249269fd
https://pubmed.ncbi.nlm.nih.gov/31544995

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Prospective Observational Study of Sirolimus as Primary Immunosuppression After Renal Transplantation

Autor: Mark D, Pescovitz, Nosratollah, Nezakatgoo, Marc I, Lorber, Bjorn, Nashan, Helio, Tedesco-Silva, Bertram L, Kasiske, Federico J Juarez, de la Cruz, Graeme, Russ, Joseph, Campistol, Paul A, Keown, M, Lorber

Publikováno v: Transplantation. 88:1010-1018

BACKGROUND.: Sirolimus (SRL) is an important component of clinical immunosuppression in renal transplantation, but few international studies have examined how this agent is used in routine practice. METHODS.: Within a large prospective pharmacoepidem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf7509ececf8bd1fac9d96f3976752c
https://doi.org/10.1097/tp.0b013e3181b9d0da

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Amelioration of Human Allograft Arterial Injury by Atorvastatin or Simvastatin Correlates With Reduction of Interferon-γ Production by Infiltrating T Cells

Autor: Alfred L. M. Bothwell, Jordan S. Pober, Deepak A. Rao, Yinong Wang, George Tellides, Lisa Cuchara, Tai Yi, Christopher M. Colangelo, Paul C. Tang, Marc I. Lorber

Publikováno v: Transplantation. 86:719-727

Background Graft arteriosclerosis (GA) is an important factor limiting long-term outcomes after organ transplantation. We have used a chimeric humanized mouse system to model this arteriopathy in human vessels, and found that the morphologic and func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f5dc226db69727cfbb2b8ab4106f217
https://doi.org/10.1097/tp.0b013e318183eefa

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A Phase I/II Randomized Open-Label Multicenter Trial of Efalizumab, a Humanized Anti-CD11a, Anti-LFA-1 in Renal Transplantation

Autor: P. Rajagopalan, Mark D. Pescovitz, Robert Mendez, Douglas P. Slakey, Alan H. Wilkinson, Marvin R. Garovoy, D. Laskow, K. Butt, Marc I. Lorber, Flavio Vincenti, J. P. Garg

Publikováno v: American Journal of Transplantation. 7:1770-1777

Leukocyte function associated antigen-1 (LFA-1) has a multifaceted role in the immune response, including adhesion and trafficking of leukocytes, stabilizing the immune synapse of the MHC-TCR complex and providing costimulation signals. Monoclonal an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab84513516e01f604c4e154897e9cc4f
https://doi.org/10.1111/j.1600-6143.2007.01845.x

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Alloimmune-Mediated Vascular Remodeling of Human Coronary Artery Grafts in Immunodeficient Mouse Recipients Is Independent of Preexisting Atherosclerosis

Autor: Jordan S. Pober, Marc I. Lorber, Yinong Wang, Tai Yi, Liping Zhao, George Tellides, Usman Ahmad

Publikováno v: Transplantation. 83:1501-1505

Vascular remodeling rather than intimal thickening is the most important determinant of luminal loss in cardiac graft arteriosclerosis. The impact of donor-transmitted atherosclerotic lesions on alloimmune-mediated arterial injury in an experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d52f70152dafce3ed305f46da075af2
https://doi.org/10.1097/01.tp.0000264560.51845.67

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