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Certain O, O-dialkyl-S-(?-N,N-cyclohexylmethylaminoethyl)thiophosphates, selective inhibitors of butyrylcholinesterase

Autor: A. P. Brestkin, N. N. Godovikov, S. A. Trifonova, L. I. Ginetsinskaya, M. I. Kabachnik, E. G. Kireeva, I. L. Brik

Publikováno v: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 25:861-864

1. O,O-Diisopropyl-, O,O-dipropyl, and O,O-dibutyl-S-(β-N, N-cyclohexy]methylaminoethyl)thiophosphates and their methiodides were synthesized and their anticholinesterase activity was determined in relation to butyrylcholinesterase from horse blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdabadf3f3145171587e9e3138458f3b
https://doi.org/10.1007/bf00922397

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Inhibition of cholinesterases by O,O-dipropyl S-(?-arylmethylaminoethyl) thiophosphates and their methiodides

Autor: Ya. S. Smusin, M. I. Kabachnik, I. L. Brik, A. P. Brestkin, S. A. Trifonova, N. N. Godovikov, N. N. Svidritskaya

Publikováno v: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 23:2712-2715

A study was made of the anticholinesterase activity of some O,O-dibutyl S-(β-N,N-aryl-methylaminoethyl) thiophosphates and their methiodides toward the butyrylcholinesterase of horse blood serum and toward the acetylcholinesterase of human blood ery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0eb88f6440e9eab9aed05a9f5e150e59
https://doi.org/10.1007/bf00923712

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Synthesis, reaction with esterases, and toxicity of O-alkyl S-(carbalkoxymethylmercapto)methyl methylthiophosphonates

Autor: Yu. S. Kagan, T. A. Mastryukova, A. N. Fedin, Z. Tilyabaev, Yu. E. Mandel'shtam, A. P. Brestkin, A. É. Shipov, T. I. Nozhko, M. I. Kabachnik, E. A. Ershova, S. A. Roslavtseva, I. L. Brik, Z. K. Emkuzheva

Publikováno v: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 29:838-842

1. A number of O-alkyl S-(carbalkoxymethylmercapto)methyl methylthiophosphonates was obtained by reacting the sodium salts of methylthiophosphonic acids with halo derivatives. 2. It was found for the obtained compounds that increasing the size of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58ec78a1e1c48f7f71e99f3e6468da96
https://doi.org/10.1007/bf00949696

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Anticholinesterase properties of o-ethyl-s-(?-aryloxyethyl)methylthiophosphonates

Autor: I. L. Brik, A. P. Brestkin, M. I. Kabachnik, N. N. Godovikov, N. E. Teplov

Publikováno v: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 16:1854-1857

1. The rate constants of the inhibition of cholinesterase by O-ethyl-S-(β-aryloxyethyl)methylthiophosphonates, as well as the rate constants of alkaline hydrolysis, were determined. 2. The anticholinesterase activity of O-ethyl-S-(β-aryloxyethyl)me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0aba5198d7b9bbd8540a1933e2188f71
https://doi.org/10.1007/bf00909570

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Anticholinesterase properties of O,O-diisopropyl S-(?-N,N-arylmethylaminoethyl) thiophosphates and their methiodides

Autor: I. L. Brik, M. I. Kabachnik, A. P. Brestkin, E. G. Kireeva, S. A. Trifonova, N. N. Godovikov

Publikováno v: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 25:410-412

1. The anticholinesterase activity of some O,O-diisopropyl S-(β-N,N-arylmethylaminoethyl) thiophosphates and their methiodides was studied toward the acetylcholinesterase of human blood erythrocytes and toward the butyrylcholinesterase of horse bloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d27397443e2cd4d21b9e9bde34cdc83f
https://doi.org/10.1007/bf00922489

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Inhibition of cholinesterases by O,O-dibutyl S-(?-N,N-arylmethylaminoethyl) thiophosphates and their methiodides

Autor: A. P. Brestkin, I. L. Brik, N. N. Godovikov, M. I. Kabachnik, N. N. Svidritskaya, Ya. S. Smusin, S. A. Trifonova

Publikováno v: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 24:2694-2696

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::606e5805d0d3b7c3cb536b3d35a3175c
https://doi.org/10.1007/bf01152880

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Inhibition of acetylcholinesterase by O,O-diethyl S-[?-(arylmethylamino)ethyl]thiophosphates and their methyl sulfates

Autor: N. E. Teplov, L. I. Ginetsinskaya, N. N. Godovikov, I. L. Brik, A. P. Brestkin, M. I. Kabachnik

Publikováno v: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 17:1966-1968

1. The rate constants for the inhibition of acetycholinesterase by O,O-diethyl S-[β-(arylmethylamino)ethyl] thiophosphates and their methyl sulfates were determined. 2. Changes in the inhibiting capacity in the series of O,O-diethyl S-[β-(arylmethy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f4ce533ef883fe3f3eb6ec3232eae54
https://doi.org/10.1007/bf00904993

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