Výsledky vyhledávání - "I. L. Andrulis"

Identification and characterization of missense alterations in the BRCA1 associated RING domain (BARD1) gene in breast and ovarian cancer

Autor: M K Sauer, I L Andrulis

Publikováno v: Journal of medical genetics. 42(8)

Background: BRCA1 associated RING domain protein (BARD1) was originally identified due to its interaction with the RING domain of BRCA1. BARD1 is required for S phase progression, contact inhibition and normal nuclear division, as well as for BRCA1 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd723440f584f1a2f682b399bf3e7fa8
https://pubmed.ncbi.nlm.nih.gov/16061562

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Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma

Autor: N, Gokgoz, J S, Wunder, S, Mousses, S, Eskandarian, R S, Bell, I L, Andrulis

Publikováno v: Cancer. 92(8)

In some malignancies, p53 mutations are associated with tumor progression. To address the role of p53 mutations in the development and progression of osteosarcoma, the authors analyzed specimens from 247 patients with primary localized osteosarcomas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0b8b8611d28a8725e335628d1d3f283
https://pubmed.ncbi.nlm.nih.gov/11596036

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The Cooperative Familial Registry for Breast Cancer Studies: design and first year recruitment rates in Ontario

Autor: H J, Sutherland, J, Lacroix, J, Knight, I L, Andrulis, N F, Boyd

Publikováno v: Journal of clinical epidemiology. 54(1)

The Ontario Familial Breast Cancer Registry (OFBCR) is one of six international sites of the Cooperative Familial Registry for Breast Cancer Studies collecting family history, epidemiologic information, and blood samples from families (with various p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d132f8289c29a1e67a8dabd6ce99e04
https://pubmed.ncbi.nlm.nih.gov/11165472

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p53 mutations in epithelial ovarian cancers: possible role in predicting chemoresistance

Autor: S, Laframboise, W, Chapman, J, McLaughlin, I L, Andrulis

Publikováno v: Cancer journal (Sudbury, Mass.). 6(5)

The investigators undertook a retrospective study to determine (1) whether p53 mutations are predictors of survival in patients with advanced epithelial ovarian cancer, (2) whether p53 status by sequencing is associated with established prognostic in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d45c12ef01d0809e6194979c4c659b36
https://pubmed.ncbi.nlm.nih.gov/11079169

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Mutational analysis of BRCA1 and BRCA2 genes in Chinese ovarian cancer identifies 6 novel germline mutations

Autor: U S, Khoo, H Y, Ngan, A N, Cheung, K Y, Chan, J, Lu, V W, Chan, S, Lau, I L, Andrulis, H, Ozcelik

Publikováno v: Human mutation. 16(1)

Germline mutations in the BRCA1 and BRCA2 genes predispose women to breast and ovarian cancer. An incidence of 5% and 3.3% respectively has been reported of BRCA1 and BRCA2 mutations in women with ovarian cancer unselected for family history. The con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df6a2533dd651484230682d1eacec219
https://pubmed.ncbi.nlm.nih.gov/10874312

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Perceptions of Ashkenazi Jewish breast cancer patients on genetic testing for mutations in BRCA1 and BRCA2

Autor: K A, Phillips, E, Warner, W S, Meschino, J, Hunter, M, Abdolell, G, Glendon, I L, Andrulis, P J, Goodwin

Publikováno v: Clinical genetics. 57(5)

The perceived benefits and risks of genetic testing may vary between groups of individuals with different cultural, demographic, and family history features. This multicentre study examined the factors that influenced the decision to undergo genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36d7f2593597d0eeb0830baf028a1020
https://pubmed.ncbi.nlm.nih.gov/10852372

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Mutation in the coding region of the BRCA1 gene leads to aberrant splicing of the transcript

Autor: H, Ozcelik, R, Nedelcu, V W, Chan, X H, Shi, J, Murphy, B, Rosen, I L, Andrulis

Publikováno v: Human mutation. 14(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42b12cfbbc4be16f888268ccdd0ee1a8
https://pubmed.ncbi.nlm.nih.gov/10571952

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Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma

Autor: S, Burrow, I L, Andrulis, M, Pollak, R S, Bell

Publikováno v: Journal of surgical oncology. 69(1)

We have previously shown that insulin-like growth factor (IGF)-responsive murine sarcomas demonstrate inhibition of local and metastatic disease growth when implanted in an IGF-deficient host animal. In this experiment, we tested whether IGF receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d3836254924467ad5dddcc7ebfe99279
https://pubmed.ncbi.nlm.nih.gov/9762887

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