Zobrazeno 1 - 10
of 157
pro vyhledávání: '"I. Koning"'
Autor:
Birol Cabukusta, Shalom Borst Pauwels, Jimmy JLL Akkermans, Niek Blomberg, Aat A Mulder, Roman I Koning, Martin Giera, Jacques Neefjes
Publikováno v:
eLife, Vol 12 (2024)
Numerous lipids are heterogeneously distributed among organelles. Most lipid trafficking between organelles is achieved by a group of lipid transfer proteins (LTPs) that carry lipids using their hydrophobic cavities. The human genome encodes many int
Externí odkaz:
https://doaj.org/article/ca42fcf193c74b28bc6f3a49ccfe19f0
Autor:
Kim M. A. De Kleijn, Wieteke A. Zuure, Kirsten R. Straasheijm, Marijn B. Martens, M. Cristina Avramut, Roman I. Koning, Gerard J. M. Martens
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Background Three-dimensional (3D) human brain spheroids are instrumental to study central nervous system (CNS) development and (dys)function. Yet, in current brain spheroid models the limited variety of cell types hampers an integrated explo
Externí odkaz:
https://doaj.org/article/a4405140e35247bb8156819432f89c24
Autor:
Marije Koning, Sébastien J. Dumas, M. Cristina Avramut, Roman I. Koning, Elda Meta, Ellen Lievers, Loes E. Wiersma, Mila Borri, Xue Liang, Lin Xie, Ping Liu, Fang Chen, Lin Lin, Yonglun Luo, Jaap Mulder, H. Siebe Spijker, Thierry Jaffredo, Bernard M. van den Berg, Peter Carmeliet, Cathelijne W. van den Berg, Ton J. Rabelink
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-16 (2022)
Abstract Human induced pluripotent stem cell-derived kidney organoids have potential for disease modeling and to be developed into clinically transplantable auxiliary tissue. However, they lack a functional vasculature, and the sparse endogenous endo
Externí odkaz:
https://doaj.org/article/c52fe544ed8549398c7d1b8dc62f2d02
Autor:
Ruben V. Huis in ‘t Veld, Pablo Lara, Martine J. Jager, Roman I. Koning, Ferry Ossendorp, Luis J. Cruz
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Extracellular vesicles (EVs) are promising drug carriers of photosensitizers for photodynamic therapy (PDT) in cancer treatment, due to their ability to circulate in blood and enter cells efficiently. The therapeutic potential of EVs has bee
Externí odkaz:
https://doaj.org/article/d1583bc64cce4b1b8b12030c820a96bc
Autor:
Roman I. Koning, Hildo Vader, Martijn van Nugteren, Peter A. Grocutt, Wen Yang, Ludovic L. R. Renault, Abraham J. Koster, Arnold C. F. Kamp, Michael Schwertner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Faster cryo specimen preparation can advance cryo electron microscopy (cryoEM). Here, the authors present a vitrification device with automated sample handling for cryoEM of proteins, suspensions and cells, enabling blot-free sample thinning, dew-poi
Externí odkaz:
https://doaj.org/article/7d54a3e61dfc4794a06ac42b559224d5
Autor:
Marije E. Kuipers, D. Linh Nguyen, Angela van Diepen, Lynn Mes, Erik Bos, Roman I. Koning, Esther N. M. Nolte-’t Hoen, Hermelijn H. Smits, Cornelis H. Hokke
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Schistosomes can survive in mammalian hosts for many years, and this is facilitated by released parasite products that modulate the host’s immune system. Many of these products are glycosylated and interact with host cells via C-type lectin recepto
Externí odkaz:
https://doaj.org/article/4a5c7cd49774436ea49d296e83632948
Autor:
Muhanad Ali, Miriam E. van Gent, Amy M. de Waal, Bjorn R. van Doodewaerd, Erik Bos, Roman I. Koning, Robert A. Cordfunke, Jan Wouter Drijfhout, Peter H. Nibbering
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2867 (2023)
Synthetic antimicrobial and antibiofilm peptide (SAAP-148) commits significant antimicrobial activities against antimicrobial resistant (AMR) planktonic bacteria and biofilms. However, SAAP-148 is limited by its low selectivity index, i.e., ratio bet
Externí odkaz:
https://doaj.org/article/766b77927e0e4ada8907f81ee317660a
Autor:
Miriam E. van Gent, Tom van Baaren, Sylvia N. Kłodzińska, Muhanad Ali, Natasja Dolezal, Bjorn R. van Doodewaerd, Erik Bos, Amy M. de Waal, Roman I. Koning, Jan Wouter Drijfhout, Hanne Mørck Nielsen, Peter H. Nibbering
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 429 (2023)
Chronic wound infections colonized by bacteria are becoming more difficult to treat with current antibiotics due to the development of antimicrobial resistance (AMR) as well as biofilm and persister cell formation. Synthetic antibacterial and antibio
Externí odkaz:
https://doaj.org/article/b518551780ec46efb7e3e99e2e77ddab
Autor:
Marije E. Kuipers, Roman I. Koning, Erik Bos, Cornelis H. Hokke, Hermelijn H. Smits, Esther N. M. Nolte-‘t Hoen
Publikováno v:
Journal of Immunology Research, Vol 2022 (2022)
In the past decade, the interest in helminth-derived extracellular vesicles (EVs) increased owing to their role in pathogen-host communication. However, the availability of EVs from these parasitic worms is often limited due to the restricted occurre
Externí odkaz:
https://doaj.org/article/f4f7bb5efffd4e81a568248aa9b0387f
Autor:
Aysegul Sapmaz, Ilana Berlin, Erik Bos, Ruud H. Wijdeven, Hans Janssen, Rebecca Konietzny, Jimmy J. Akkermans, Ayse E. Erson-Bensan, Roman I. Koning, Benedikt M. Kessler, Jacques Neefjes, Huib Ovaa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Though ubiquitin is known to broadly influence endosomal trafficking, few ubiquitin-utilizing enzymes targeting endosomal regulators are known. Here, the authors find that the deubiquitylating enzyme (DUB) USP32 influences endosomal membrane dynamics
Externí odkaz:
https://doaj.org/article/03097ad9b5bc4f32abfc5298bf844d05