Sertoli Cell Development and Function in an Animal Model of Testicular Dysgenesis Syndrome1

Autor: Chris McKinnell, Marion F Walker, I. Kim Mahood, Richard M. Sharpe, Hayley M. Scott, Diana Ferrara, Gary R. Hutchison

Publikováno v: Biology of Reproduction. 78:352-360

Pregnancy exposure to di(n-butyl) phthalate (DBP) in rats induces a testicular dysgenesislike syndrome (TDS) in male offspring. Earlier studies suggested altered Sertoli cell development/maturation may result, especially in testes that become cryptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7e2efbdc3d9020f3a89c9b283ff804f
https://doi.org/10.1095/biolreprod.107.064006

Effects of Monobutyl and Di( n -butyl) Phthalate in Vitro on Steroidogenesis and Leydig Cell Aggregation in Fetal Testis Explants from the Rat: Comparison with Effects in Vivo in the Fetal Rat and Neonatal Marmoset and in Vitro in the Human

Autor: Irene Greig, Keith Morris, I. Kim Mahood, Marion F Walker, Richard M. Sharpe, Shiona M. Coutts, Richard A. Anderson, Chris McKinnell, Hayley M. Scott, Nina Hallmark, Rosemary A. L. Bayne

Publikováno v: Environmental Health Perspectives. 115:390-396

Disorders of male reproductive health, including testicular cancer, cryptorchidism, hypospadias, and low sperm counts, are common and may be increasing in incidence in the Western World (Sharpe and Skakkebaek 2003; Skakkebaek et al. 2001). Although t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01873cc2266636920b6d99664e9a4e7b
https://doi.org/10.1289/ehp.9490

In utero exposure to di(n-butyl) phthalate and testicular dysgenesis:comparison of fetal and adult end points and their dose sensitivity

Autor: Richard M. Sharpe, Marion F Walker, Hayley M. Scott, Richard J. Brown, Nina Hallmark, I. Kim Mahood

Publikováno v: Mahood, I K, Scott, H M, Brown, R, Hallmark, N, Walker, M & Sharpe, R M 2007, ' In utero exposure to di(n-butyl) phthalate and testicular dysgenesis : comparison of fetal and adult end points and their dose sensitivity ', Environmental Health Perspectives, vol. 115, no. Supplement 1, pp. 55-61 . https://doi.org/10.1289/ehp.9366
Environmental Health Perspectives

BACKGROUND: Fetal exposure of male rats to di(n-butyl) phthalate (DBP) induces reproductive disorders similar to those in human testicular dysgenesis syndrome (TDS), including infertility, cryptorchidism, focal "dysgenetic areas," and Sertoli cell-on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dacdefaabfa1a9f7cb2f9d38f4100db
https://www.pure.ed.ac.uk/ws/files/12994319/In_utero_exposure_to_di_n_butyl_phthalate_and_testicular_dysgenesis.pdf

Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human

Autor: Nina, Hallmark, Marion, Walker, Chris, McKinnell, I Kim, Mahood, Hayley, Scott, Rosemary, Bayne, Shiona, Coutts, Richard A, Anderson, Irene, Greig, Keith, Morris, Richard M, Sharpe

Publikováno v: Environmental Health Perspectives

Background Certain phthalates can impair Leydig cell distribution and steroidogenesis in the fetal rat in utero, but it is unknown whether similar effects might occur in the human. Objectives Our aim in this study was to investigate the effects of di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9415acdf70e195a9da9cca4e8efb23d
https://pubmed.ncbi.nlm.nih.gov/17431488

Abnormal Leydig Cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis

Autor: Nina Hallmark, Jane S. Fisher, I Kim Mahood, Richard M. Sharpe, Chris McKinnell, Marion F Walker

Publikováno v: Endocrinology. 146(2)

Fetal exposure of male rats to di (n-butyl) phthalate (DBP) induces testicular changes remarkably similar to testicular dysgenesis syndrome in humans; these include induction of focal areas of dysgenetic tubules in otherwise normal testes. In searchi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6836256fe23b528afbb9f636e6551320
https://pubmed.ncbi.nlm.nih.gov/15539561