Výsledky vyhledávání - "I. K. Taylor"

Evidence for a Th1-like bronchoalveolar T-cell subset and predominance of interferon-gamma gene activation in pulmonary tuberculosis

Autor: Douglas S. Robinson, R. J. Shaw, D. M. Mitchell, I K Taylor, A. B. Kay, Qutayba Hamid, Sun Ying, A. Wangoo

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 149:989-993

Mycobacterium-specific human helper T-cell clones produce a Th1 pattern of cytokines in vitro: interferon-gamma (IFN-gamma) and interleukin-2 (IL-2), but little or no IL-4 or IL-5. To test the hypothesis that a similar Th1-like pattern of cytokine ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d4bd83d686a8212c4d2bbc40840a83
https://doi.org/10.1164/ajrccm.149.4.8143065

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Relation of HIV-I in bronchoalveolar lavage cells to abnormalities of lung function and to the presence of Pneumocystis pneumonia in HIV-I seropositive patients

Autor: D M Mitchell, I K Taylor, John D. Williamson, John R. Clarke, J Fleming

Publikováno v: Thorax. 48:1222-1226

BACKGROUND--HIV is present in bronchoalveolar lavage cells of some but not all HIV seropositive patients. Abnormalities of lung function have been described in such patients in the absence of clinically overt pneumonia or other respiratory infections

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba957bfaab89d5986c2c6e20b450fd2e
https://doi.org/10.1136/thx.48.12.1222

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In vivo and in vitro effects of glucocorticosteroids on arachidonic acid metabolism and monocyte function in nonasthmatic humans

Autor: G, Manso, A J, Baker, I K, Taylor, R W, Fuller

Publikováno v: European Respiratory Journal. 5:712-716

Glucocorticosteroids are used as anti-inflammatory agents in a range of diseases, however, their mechanism of action is unknown. Recently, inhibition of arachidonic acid metabolism has been suggested as one possible mechanism of action. A series of e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112cb36f30eef9f139f21a50a99d5a05
https://doi.org/10.1183/09031936.93.05060712

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A comparative study in atopic subjects with asthma of the effects of salmeterol and salbutamol on allergen-induced bronchoconstriction, increase in airway reactivity, and increase in urinary leukotriene E excretion

Autor: I. K. Taylor, R.W. Fuller, James B.D. Palmer, Kevin M. O'Shaughnessy, Mitsuru Adachi, Nozhat B. Choudry

Publikováno v: Journal of Allergy and Clinical Immunology. 89:575-583

Salmeterol (SM) is a novel β 2 -adrenoceptor agonist with a duration of action in excess of 12 hours. Evidence from in vitro studies has also demonstrated that, unlike the short-acting β 2 -agonists, such as salbutamol (SB), it may have some anti-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43cb07314257ac295760a79a3c9e7646
https://doi.org/10.1016/0091-6749(92)90325-v

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Effect of cysteinyl-leukotriene receptor antagonist ICI 204.219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects

Autor: Kevin M. O'Shaughnessy, I. K. Taylor, R. W. Fuller, Colin Dollery

Publikováno v: The Lancet. 337:690-694

The effects of a highly selective leukotriene D4 receptor antagonist, ICI 204.219, on allergen-induced bronchoconstriction and changes in airway reactivity were evaluated in a double-blind, placebo-controlled, crossover trial. Ten atopic subjects wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e71fe146e4623118e9e6ef99747cb14
https://doi.org/10.1016/0140-6736(91)90277-v

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Thromboxane A2Biosynthesis in Acute Asthma and after Antigen Challenge

Autor: R.W. Fuller, Peter Black, Paul S. Ward, I. K. Taylor, Graham W. Taylor, Colin T. Dollery, S.E. Barrow, Kevin M. O'Shaughnessy

Publikováno v: American Review of Respiratory Disease. 143:119-125

Thromboxane A2 is a potent bronchial smooth muscle spasmogen in vitro, and it has been implicated in airway inflammation and in the genesis of bronchial hyperresponsiveness in asthma. We have examined the urinary excretion of a variety of products de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a70caca48874711c01e7b885eca592
https://doi.org/10.1164/ajrccm/143.1.119

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Pulmonary complications of HIV disease: 10 year retrospective evaluation of yields from bronchoalveolar lavage, 1983-93

Autor: R. B. Nieman, F M Moss, Richard Coker, I K Taylor, John R. Clarke, Douglas S. Robinson, R J Shaw, D. Veale, D J Evans, D M Mitchell

BACKGROUND--Pulmonary disease is a major contributor to morbidity and mortality in patients with HIV infection and AIDS. The aim of this study was to describe bronchoscopic findings and the spectrum of pulmonary pathogens in HIV seropositive patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8666a2b82d39eac55c1ce91cf99d73a0
https://europepmc.org/articles/PMC1021344/

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Mycobacterial infection in HIV seropositive and seronegative populations, 1987-93

Autor: Richard Coker, D M Mitchell, R J Shaw, D J Evans, I K Taylor

BACKGROUND--Although the causes of the worldwide resurgence of tuberculosis are multifactorial, the HIV epidemic is believed to have had a central role. Control is further threatened by the emergence of multidrug-resistant tuberculosis. METHODS--A re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c1dc137d33835efc2f9d056de97c00
https://europepmc.org/articles/PMC475085/

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Pharmacological modulation of platelet-derived growth factor (B) mRNA expression in alveolar macrophages and adherent monocytes

Autor: R.J. Shaw, S. Kotecha, I. K. Taylor

Publikováno v: Pulmonary pharmacology. 7(6)

The macrophage profibrotic cytokine, Platelet Derived Growth Factor B [PDGF(B)], is thought to play a central role in orchestrating the fibrotic response in the pathogenesis of cryptogenic fibrosing alveolitis. In this study, we have asked if drugs t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30271c90ca7e17ea1ec26e113fe4602f
https://pubmed.ncbi.nlm.nih.gov/7549226

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