Zobrazeno 1 - 9
of 9
pro vyhledávání: '"I. J. Frame"'
Autor:
Widdowson Katherine L, Lorena A. Kallal, Yvett Sosa, Matthew S. Steiginga, Michael T. Ouellette, Myles H. Akabas, I. J. Frame, Andrew J. Pope, Roman Deniskin, Todd L. Graybill, Deepak Bandyopadhyay, Robert J. Young
Publikováno v:
ACS Infectious Diseases. 5:1738-1753
Emerging resistance to current antimalarial medicines underscores the importance of identifying new drug targets and novel compounds. Malaria parasites are purine auxotrophic and import purines via the Plasmodium falciparum equilibrative nucleoside t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19f40902415475df50da84cc0ab7b2af
https://doi.org/10.1021/acsinfecdis.9b00168
https://doi.org/10.1021/acsinfecdis.9b00168
Autor:
Yvett, Sosa, Roman, Deniskin, I J, Frame, Matthew S, Steiginga, Deepak, Bandyopadhyay, Todd L, Graybill, Lorena A, Kallal, Michael T, Ouellette, Andrew J, Pope, Katherine L, Widdowson, Robert J, Young, Myles H, Akabas
Publikováno v:
ACS Infect Dis
Emerging resistance to current antimalarial medicines underscores the importance of identifying new drug targets and novel compounds. Malaria parasites are purine auxotrophic and import purines via the Plasmodium falciparum Equilibrative Nucleoside T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62c102406f489238db600f20b212aa91
https://pubmed.ncbi.nlm.nih.gov/31373203
https://pubmed.ncbi.nlm.nih.gov/31373203
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 1-11 (2016)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
Infection with Plasmodium falciparum and vivax cause most cases of malaria. Emerging resistance to current antimalarial medications makes new drug development imperative. Ideally a new antimalarial drug should treat both falciparum and vivax malaria.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d369a70028fd3fb4d411b54bb547d0d
https://doi.org/10.1016/j.ijpddr.2015.11.003
https://doi.org/10.1016/j.ijpddr.2015.11.003
Autor:
Ian M. Willis, Roman Deniskin, Olivia Coburn-Flynn, Myles H. Akabas, Robyn D. Moir, Alison Rinderspacher, David A. Fidock, I. J. Frame, Francine Katz, Sophie H. Adjalley, Donald W. Landry, Shi Xian Deng
Publikováno v:
ACS Chemical Biology. 10:775-783
Equilibrative transporters are potential drug targets; however, most functional assays involve radioactive substrate uptake that is unsuitable for high-throughput screens (HTS). We developed a robust yeast-based growth assay that is potentially appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1942696c19fce59752e93741c938eba
https://doi.org/10.1021/cb500981y
https://doi.org/10.1021/cb500981y
Publikováno v:
Annals of the New York Academy of Sciences. 1342:19-28
Infection with Plasmodium species parasites causes malaria. Plasmodium parasites are purine auxotrophs. In all life cycle stages, they require purines for RNA and DNA synthesis and other cellular metabolic processes. Purines are imported from the hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f0800502ff98eae7117d206d626f027
https://doi.org/10.1111/nyas.12568
https://doi.org/10.1111/nyas.12568
Autor:
Ralf Brunner, David A. Fidock, Christoph Boss, Caroline L. Ng, Reto Brun, Ingrid B. Müller, Paul S. Callaghan, Bibia Heidmann, Till S. Voss, Sergio Wittlin, Romain Siegrist, I. J. Frame, Olivier Corminboeuf, Myles H. Akabas, Amélie Le Bihan, Richard W. D. Welford, Michelle F. Paguio, Corinna Mattheis, Paul D. Roepe, Hamed Aissaoui, Paul Jenö, Suzette Moes, Christoph Binkert
Publikováno v:
Journal of Biological Chemistry. 288:22576-22583
A representative of a new class of potent antimalarials with an unknown mode of action was recently described. To identify the molecular target of this class of antimalarials, we employed a photo-reactive affinity capture method to find parasite prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae6dab21838e58d1322f5002cde6596
https://doi.org/10.1074/jbc.m113.453159
https://doi.org/10.1074/jbc.m113.453159
Publikováno v:
Biochemical Journal. 446:179-190
Malaria, caused by Plasmodia parasites, affects hundreds of millions of people. As purine auxotrophs, Plasmodia use transporters to import host purines for subsequent metabolism by the purine salvage pathway. Thus purine transporters are attractive d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d437031fef84a44699e2f6ff6f412ec
https://doi.org/10.1042/bj20112220
https://doi.org/10.1042/bj20112220
Publikováno v:
Journal of Biological Chemistry. 285:17001-17010
Purine transport is essential for malaria parasites to grow because they lack the enzymes necessary for de novo purine biosynthesis. The Plasmodium falciparum Equilibrative Nucleoside Transporter 1 (PfENT1) is a member of the equilibrative nucleoside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b011582f1e810064f44e1ac496b25bd
https://doi.org/10.1074/jbc.m110.115758
https://doi.org/10.1074/jbc.m110.115758
Publikováno v:
Annals of the New York Academy of Sciences. 1342
Infection with Plasmodium species parasites causes malaria. Plasmodium parasites are purine auxotrophs. In all life cycle stages, they require purines for RNA and DNA synthesis and other cellular metabolic processes. Purines are imported from the hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d65dab304ae0bb7e54aee42a2247595
https://pubmed.ncbi.nlm.nih.gov/25424653
https://pubmed.ncbi.nlm.nih.gov/25424653