Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation

Autor: D. Wragg, Q. Liu, Z. Lin, V. Riggio, C. A. Pugh, A. J. Beveridge, H. Brown, D. A. Hume, S. E. Harris, I. J. Deary, A. Tenesa, J. G. D. Prendergast

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

For most human genes nearby regulatory variants explain only a small proportion of their expression variation between individuals. Here the authors show how the impact of a gene’s set of nearby regulatory variant is often linked to the expression l

Externí odkaz: https://doaj.org/article/caf3c6c3130d4e6b811575159199dd1a

Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)

Autor: G, Davies, R E, Marioni, D C, Liewald, W D, Hill, S P, Hagenaars, S E, Harris, S J, Ritchie, M, Luciano, C, Fawns-Ritchie, D, Lyall, B, Cullen, S R, Cox, C, Hayward, D J, Porteous, J, Evans, A M, McIntosh, J, Gallacher, N, Craddock, J P, Pell, D J, Smith, C R, Gale, I J, Deary

Publikováno v: Davies, G, Marioni, R E, Liewald, D C, Hill, W D, Hagenaars, S P, Harris, S E, Ritchie, S J, Luciano, M, Fawns-Ritchie, C, Lyall, D, Cullen, B, Cox, S R, Hayward, C, Porteous, D J, Evans, J, Mcintosh, A M, Gallacher, J, Craddock, N, Pell, J P, Smith, D J, Gale, C R & Deary, I J 2016, ' Genome-wide association study of cognitive functions and educational attainment in UK Biobank ( N =112 151) ', Molecular Psychiatry, vol. 21, no. 6, pp. 758-767 . https://doi.org/10.1038/mp.2016.45
Molecular Psychiatry

People’s differences in cognitive functions are partly heritable and are associated with important life outcomes. Previous genome-wide association (GWA) studies of cognitive functions have found evidence for polygenic effects yet, to date, there ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c9140328e2face379956997bb121d81f
https://ora.ox.ac.uk/objects/uuid:5723f54c-bcaf-423c-b5e0-df6adc911665

Genetic contributions to Trail Making Test performance in UK Biobank

Autor: S P, Hagenaars, S R, Cox, W D, Hill, G, Davies, D C M, Liewald, S E, Harris, A M, McIntosh, C R, Gale, I J, Deary

Publikováno v: Molecular psychiatry. 23(7)

The Trail Making Test (TMT) is a widely used test of executive function and has been thought to be strongly associated with general cognitive function. We examined the genetic architecture of the TMT and its shared genetic aetiology with other tests

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1160d19bb5065e78826294dc279a2551
https://pubmed.ncbi.nlm.nih.gov/28924184

Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts

Autor: H C, Whalley, M J, Adams, L S, Hall, T-K, Clarke, A M, Fernandez-Pujals, J, Gibson, E, Wigmore, J, Hafferty, S P, Hagenaars, G, Davies, A, Campbell, C, Hayward, S M, Lawrie, D J, Porteous, I J, Deary, A M, McIntosh

Publikováno v: Translational Psychiatry

Major depressive disorder (MDD) is known for its substantial clinical and suspected causal heterogeneity. It is characterized by low mood, psychomotor slowing and increased levels of the personality trait neuroticism; factors also associated with sch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c34fe4f663758c2c3a364b6787b2ea2e
https://pubmed.ncbi.nlm.nih.gov/27801894

Exploratory analysis of dietary intake and brain iron accumulation detected using magnetic resonance imaging in older individuals: the Lothian Birth Cohort 1936

Autor: M del C Valdés, Hernández, J, Allan, A, Glatz, J, Kyle, J, Corley, C E, Brett, S Muñoz, Maniega, N A, Royle, M E, Bastin, J M, Starr, I J, Deary, J M, Wardlaw

Publikováno v: The journal of nutrition, healthaging. 19(1)

Brain Iron Deposits (IDs) are associated with neurodegenerative diseases and impaired cognitive function in later life, but their cause is unknown. Animal studies have found evidence of relationships between dietary iron, calorie and cholesterol inta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ab412e9793fc74eac5ec7e602d81cca7
https://pubmed.ncbi.nlm.nih.gov/25560818