Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review

Autor: J. Salchow, J. Mann, B. Koch, J. von Grundherr, W. Jensen, S. Elmers, L. A. Straub, E. Vettorazzi, G. Escherich, S. Rutkowski, S. Dwinger, C. Bergelt, M. Sokalska-Duhme, S. Bielack, G. Calaminus, K. Baust, C. F. Classen, C. Rössig, J. Faber, H. Faller, I. Hilgendorf, J. Gebauer, T. Langer, M. Metzler, S. Schuster, C. Niemeyer, A. Puzik, D. Reinhardt, U. Dirksen, A. Sander, M. Köhler, J. K. Habermann, C. Bokemeyer, A. Stein

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)

Abstract Background Improved, multimodal treatment strategies have been shown to increase cure rates in cancer patients. Those who survive cancer as a child, adolescent or young adult (CAYA), are at a higher risk for therapy-, or disease-related, lat

Externí odkaz: https://doaj.org/article/b28e888c177b403f97dc1d02560d907e

BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis

Autor: Jacob D. Garritson, Jiabi Zhang, Alan Achenbach, Maroua Ferhat, Emile Eich, Chris J. Stubben, Paige L. Martinez, Anna R. Ibele, Keren I. Hilgendorf, Sihem Boudina

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)

Abstract Autocrine and paracrine signaling regulating adipogenesis in white adipose tissue remains largely unclear. Here we used single-cell RNA-sequencing (RNA-seq) and single nuclei RNA-sequencing (snRNA-seq) to identify markers of adipose progenit

Externí odkaz: https://doaj.org/article/ea29e9686fc0499989d23cbee9f8bf05

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Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

Autor: Ermelinda Porpiglia, Thach Mai, Peggy Kraft, Colin A. Holbrook, Antoine de Morree, Veronica D. Gonzalez, Keren I. Hilgendorf, Laure Frésard, Angelica Trejo, Sriram Bhimaraju, Peter K. Jackson, Wendy J. Fantl, Helen M. Blau

Publikováno v: Porpiglia, E, Mai, T, Kraft, P, Holbrook, C A, de Morree, A, Gonzalez, V D, Hilgendorf, K I, Frésard, L, Trejo, A, Bhimaraju, S, Jackson, P K, Fantl, W J & Blau, H M 2022, ' Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration ', Cell Stem Cell, vol. 29, no. 12, pp. 1653-1668.e8 . https://doi.org/10.1016/j.stem.2022.10.009
Porpiglia, E 2022, ' Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration ', Cell Stem Cell, vol. 29, pp. 1-15 . https://doi.org/10.1016/j.stem.2022.10.009

SUMMARYIn aging, skeletal muscle strength and regenerative capacity declines due, in part, to functional impairment of muscle stem cells (MuSCs), yet the underlying mechanisms remain elusive. Here we capitalize on mass-cytometry to identify high CD47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04ad7c0435d5c85adc8688e5f4b2667
https://pure.au.dk/portal/da/publications/elevated-cd47-is-a-hallmark-of-dysfunctional-aged-muscle-stem-cells-that-can-be-targeted-to-augment-regeneration(c5ff0522-3d96-48d3-98c9-5ebe9d67b333).html

GPR55 deficiency in B-cells promotes atherosclerosis and regulates plasma cell maturation

Autor: R Guillamat-Prats, D Hering, M Rami, C Haerdtner, D Santovito, P Rinne, S Pagano, N Nicolas Vuilleumier, S Schmid, A Janjic, W Enard, C Weber, L Maegdefessel, I Hilgendorf, S Steffens

Publikováno v: European Heart Journal. 43

Atherosclerosis is a chronic and multifactorial disease accompanied by an imbalance between resolving and pro-inflammatory lipid mediators. Targeting lipid signaling might offer new therapeutical targets for improving the clinical outcome in cardiova

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c5f84331799ac78e37c3c5e25116a4e
https://doi.org/10.1093/eurheartj/ehac544.3052