Výsledky vyhledávání - "I. H. Pastan"

Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1

Autor: G E, Archer, J H, Sampson, I A, Lorimer, R E, McLendon, C T, Kuan, A H, Friedman, H S, Friedman, I H, Pastan, D D, Bigner

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(9)

The incidence of neoplastic meningitis is on the rise. Neoplastic meningitis can result from a direct seeding of the neuraxis by primary brain tumors or by hematogeneous spread of systemic solid tumors. A frequent genetic alteration in primary brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8dabca3babb19bdbf69567af92fac5ec
https://pubmed.ncbi.nlm.nih.gov/10499644

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Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis

Autor: D D, Bigner, G E, Archer, R E, McLendon, H S, Friedman, H E, Fuchs, L H, Pai, J E, Herndon, I H, Pastan

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 1(12)

LMB-1 (B3-LysPE38) is an immunotoxin composed of the tumor-reactive monoclonal antibody B3 and a genetically engineered form of Pseudomonas exotoxin. Monoclonal antibody B3 reacts with a carbohydrate epitope that is found on a number of solid tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2135fbd18a5015f9cb9664757e565969
https://pubmed.ncbi.nlm.nih.gov/9815955

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Recombinant immunotoxins: new therapeutic agents for cancer treatment

Autor: I H, Pastan

Publikováno v: Cancer detection and prevention. 17(2)

We have developed new agents for the treatment of cancer by genetically modifying Pseudomonas exotoxin. We have deleted the cell-binding region of Pseudomonas exotoxin and replaced it with various growth factors or the combining regions of antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ce0dd4acce417d2f43dd8b5e9acfe64
https://pubmed.ncbi.nlm.nih.gov/8402714

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src kinase catalyzes the phosphorylation and activation of the insulin receptor kinase

Autor: Michael P. Czech, I H Pastan, K T Yu, D K Werth

Publikováno v: Journal of Biological Chemistry. 260:5838-5846

When a partially purified insulin receptor preparation immobilized on insulin-agarose is incubated with [gamma-32P]ATP, Mn2+, and Mg2+ ions, the receptor beta subunit becomes 32P-labeled. The 32P-labeling of the insulin receptor beta subunit is incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffd97dc5442c0e778d974f9255d4ea7c
https://doi.org/10.1016/s0021-9258(18)89098-6

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Purification of a tyrosine-specific protein kinase from Rous sarcoma virus-induced rat tumor

Autor: N D Richert, D L Blithe, I H Pastan

Publikováno v: Journal of Biological Chemistry. 257:7135-7142

We have identified a tyrosine kinase activity present in tumors which were raised in rats by subcutaneous injection of Rous sarcoma virus-transformed rat cells (SR-NRK). This kinase phosphorylates tyrosine on the heavy chain of IgG from tumor-bearing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b49e39d3ce9bdfa5d8b9f4b4a94a85a8
https://doi.org/10.1016/s0021-9258(18)34547-2

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Properties of the src kinase purified from Rous sarcoma virus-induced rat tumors

Autor: D L Blithe, I H Pastan, N D Richert

Publikováno v: Journal of Biological Chemistry. 257:7143-7150

We recently described a method for the purification of a protein kinase related to pp60src from Rous sarcoma virus-induced rat tumors (Blithe, D. L., Richert, N. D., and Pastan, I. H. (1982) J. Biol. Chem. 257, 7135-7142). In this report, we describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::512be939abec3cf33b9eb88ce5f56053
https://doi.org/10.1016/s0021-9258(18)34548-4

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Aging and cancer: cyclic 3', 5'-adenosine monophosphate and altered gene activity

Autor: I H, Pastan, M, Willingham, B, de Crombrugghe, M M, Gottesman

Publikováno v: National Cancer Institute monograph. 60

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85035740e4b45b4c8dec696c57d9f497
https://pubmed.ncbi.nlm.nih.gov/6289108

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Reversible and irreversible inhibitors of clustering of alpha 2M in clathrin-coated pits on the surface of fibroblasts

Autor: R B, Dickson, R, Schlegel, M C, Willingham, I H, Pastan

Publikováno v: Experimental cell research. 140(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::93160f2e090492cb92d391d7c0cf04be
https://pubmed.ncbi.nlm.nih.gov/6179782

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Image intensification techniques for detection of proteins in cultured cells

Autor: M C, Willingham, I H, Pastan

Publikováno v: Methods in enzymology. 98

We describe here the components and uses of two image intensifier systems. The SIT camera system is convenient, relatively inexpensive, readily adaptable to most microscopes, and reliable. It suffers from lack of resolution at high gain levels and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::833ca8deb44afccd85b0cbefc785588c
https://pubmed.ncbi.nlm.nih.gov/6669050

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