Zobrazeno 1 - 10 of 33 pro vyhledávání: '"I. H. Goldberg"'
1
Enediyne-mediated DNA damage in nuclei is modulated at the level of the nucleosome
Autor: L, Yu, I H, Goldberg, P C, Dedon
Publikováno v: The Journal of biological chemistry. 269(6)
DNA damage in HeLa nuclei and isolated nucleosome core particles has been examined for several members of the enediyne family of antitumor antibiotics: calicheamicin gamma 1I (CAL), esperamicin A1 (ESP A1), esperamicin C (ESP C), and neocarzinostatin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7619ccb81d8dd24be74e07fb3e34e69c
https://pubmed.ncbi.nlm.nih.gov/8307975
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2
Selective abstraction of 2H from C-1' of the C residue in AGC.ICT by the radical center at C-2 of activated neocarzinostatin chromophore: structure of the drug/DNA complex responsible for bistranded lesion formation
Autor: S M, Meschwitz, R G, Schultz, G W, Ashley, I H, Goldberg
Publikováno v: Biochemistry. 31(38)
Glutathione-activated neocarzinostatin chromophore (NCS-Chrom) generates bistranded lesions at AGC.GCT sequences in DNA, consisting of an abasic site at the C residue and a strand break at the T residue on the complementary strand, due to hydrogen at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::310dea258fe1c5872b690f0a5a889403
https://pubmed.ncbi.nlm.nih.gov/1390698
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3
Sequence-specific double-strand breakage of DNA by neocarzinostatin involves different chemical mechanisms within a staggered cleavage site
Autor: P C, Dedon, I H, Goldberg
Publikováno v: The Journal of biological chemistry. 265(25)
Direct double-strand breaks in DNA have been implicated in cellular lethality of the antitumor antibiotic neocarzinostatin, but the mechanism of their formation has not been elucidated. Evidence is presented that neocarzinostatin causes sequence-spec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::019b2f2b98c2ac65d08dffda2544578b
https://pubmed.ncbi.nlm.nih.gov/2144279
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5
Role of epoxide in neocarzinostatin chromophore stability and action
Autor: S H, Lee, I H, Goldberg
Publikováno v: Molecular pharmacology. 33(4)
To determine the role of the epoxide moiety of the nonprotein chromophore of the antitumor antibiotic neocarzinostatin in its ability to damage DNA, the diol monomethyl ether derivative was prepared, and its stability and biological properties were s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a4e2c37a38af34797cb7e8b1512ddfd
https://pubmed.ncbi.nlm.nih.gov/2965788
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6
Molecular mechanism of novel DNA sugar damage by an antitumour protein antibiotic
Autor: I H, Goldberg, L S, Kappen, L F, Povirk, D H, Chin
Publikováno v: Drugs under experimental and clinical research. 12(6-7)
Neocarzinostatin (NCS) belongs to a family of antitumour protein antibiotics that selectively inhibit DNA synthesis. Replicon initiation in mammalian cells is selectively inhibited by NCS, and cells defective in DNA repair, such as ataxia telangiecta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14e149d7d432c76221cc8bf9315d1e26
https://pubmed.ncbi.nlm.nih.gov/2943568
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9
Reversible modification of arginine residues in neocarzinostatin. Isolation of a biologically active 89-residue fragment from the tryptic hydrolysate
Autor: T S, Samy, L S, Kappen, I H, Goldberg
Publikováno v: The Journal of biological chemistry. 255(8)
Reaction of the antitumor protein neocarzinostatin with 1,2-cyclohexanedione in 0.25 M borate buffer, pH 9.0, resulted in complete modification of arginine residues in positions 66, 67, and 78. The arginine-modified protein lost its native structure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75ed27f1edcef63d37dddd607ecc4c8c
https://pubmed.ncbi.nlm.nih.gov/6444949
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