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Akademický článek

Physicochemical, biological, functional and toxicological characterization of the European follow-on glatiramer acetate product as compared with Copaxone

Publikováno v: eNeurologicalSci, Vol 12, Iss , Pp 19-30 (2018)

For more than 20 years, Copaxone (glatiramer acetate, Teva), a non-biological complex drug, has been a safe and effective treatment option for multiple sclerosis. In 2016, a follow-on glatiramer acetate product (FOGA, Synthon) was approved in the EU.

Externí odkaz: https://doaj.org/article/b5dd37eb8b3347dd98950b25066def71

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Akademický článek

Regulation of mitochondrial oxidative phosphorylation through tight control of cytochrome c oxidase in health and disease – Implications for ischemia/reperfusion injury, inflammatory diseases, diabetes, and cancer

Autor: Lucynda Pham, Tasnim Arroum, Junmei Wan, Lauren Pavelich, Jamie Bell, Paul T. Morse, Icksoo Lee, Lawrence I. Grossman, Thomas H. Sanderson, Moh H. Malek, Maik Hüttemann

Publikováno v: Redox Biology, Vol 78, Iss , Pp 103426- (2024)

Mitochondria are essential to cellular function as they generate the majority of cellular ATP, mediated through oxidative phosphorylation, which couples proton pumping of the electron transport chain (ETC) to ATP production. The ETC generates an elec

Externí odkaz: https://doaj.org/article/73a08391ef804f41ac18e230747e8c3b

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Akademický článek

HIF-1α regulates IL-1β and IL-17 in sarcoidosis

Autor: Jaya Talreja, Harvinder Talwar, Christian Bauerfeld, Lawrence I Grossman, Kezhong Zhang, Paul Tranchida, Lobelia Samavati

Publikováno v: eLife, Vol 8 (2019)

Sarcoidosis is a complex systemic granulomatous disease of unknown etiology characterized by the presence of activated macrophages and Th1/Th17 effector cells. Data mining of our RNA-Seq analysis of CD14+monocytes showed enrichment for metabolic and

Externí odkaz: https://doaj.org/article/c5127b6a39aa4599aba757c097615e7e

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Akademický článek

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Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer

Autor: Deya Obaidat, Roberta Giordo, Erica L. Kleinbrink, Emilia Banisad, Lawrence I. Grossman, Rooshan Arshad, Azadeh Stark, Marie-Claire Maroun, Leonard Lipovich, Félix Fernandez-Madrid

Publikováno v: Frontiers in Genetics. 13

Autoantibodies against mitochondrial-derived antigens play a key role in chronic tissue inflammation in autoimmune disorders and cancers. Here, we identify autoreactive nuclear genomic DNA (nDNA)-encoded mitochondrial gene products (GAPDH, PKM2, GSTP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef5bc03c7c4f5bbab99231dc6efad3b8
https://doi.org/10.3389/fgene.2022.970619

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MNRR1 activation by nitazoxanide abrogates lipopolysaccharide-induced preterm birth in mice

Autor: Neeraja Purandare, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Jose Galaz, Roberto Romero, Yue Xi, Andrew Fribley, Lawrence I. Grossman, Siddhesh Aras

Intra-amniotic inflammation leading to preterm birth is one of the leading causes of neonatal morbidity and mortality. We recently found that the mitochondrial levels of MNRR1 (Mitochondrial Nuclear Retrograde, Regulator 1; also called CHCHD2, AAG10,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5430f47a0851634f70d816a1c3595700
https://doi.org/10.1101/2023.01.30.525762

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Fetal and maternal NLRP3 signaling is required for preterm labor and birth

Autor: Kenichiro Motomura, Roberto Romero, Jose Galaz, Li Tao, Valeria Garcia-Flores, Yi Xu, Bogdan Done, Marcia Arenas-Hernandez, Derek Miller, Pedro Gutierrez-Contreras, Marcelo Farias-Jofre, Siddhesh Aras, Lawrence I. Grossman, Adi L. Tarca, Nardhy Gomez-Lopez

Publikováno v: JCI Insight. 7

Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by invading bacteria. However, the molecular mechanisms underlying this host

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06dfd11910c7606bac3f6bd75aad8415
https://doi.org/10.1172/jci.insight.158238

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