Zobrazeno 1 - 10
of 228
pro vyhledávání: '"I. Graziani"'
Autor:
Aleksandra Wlodek, Steve G. Kendrew, Nigel J. Coates, Adam Hold, Joanna Pogwizd, Steven Rudder, Lesley S. Sheehan, Sarah J. Higginbotham, Anna E. Stanley-Smith, Tony Warneck, Mohammad Nur-E-Alam, Markus Radzom, Christine J. Martin, Lois Overvoorde, Markiyan Samborskyy, Silke Alt, Daniel Heine, Guy T. Carter, Edmund I. Graziani, Frank E. Koehn, Leonard McDonald, Alexander Alanine, Rosa María Rodríguez Sarmiento, Suzan Keen Chao, Hasane Ratni, Lucinda Steward, Isobel H. Norville, Mitali Sarkar-Tyson, Steven J. Moss, Peter F. Leadlay, Barrie Wilkinson, Matthew A. Gregory
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Reengineering polyketide synthase encoding genes to produce analogues of natural products can be slow and low-yielding. Here the authors use accelerated evolution to recombine the gene cluster for rapid production of rapamycin-related products.
Externí odkaz:
https://doaj.org/article/b36ef21246ab47bfb8cbd4e969caea7c
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
Effects of Systemic Administration of Free Payload Compared with Conventional HER2-vc0101 on Indicators of Bone Marrow Toxicity and Bone Marrow Payload Levels in Rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d432b6130242412350911c126917be78
https://doi.org/10.1158/1535-7163.22520919.v1
https://doi.org/10.1158/1535-7163.22520919.v1
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
The approval of ado-trastuzumab emtansine (T-DM1) in HER2+ metastatic breast cancer validated HER2 as a target for HER2-specific antibody–drug conjugates (ADC). Despite its demonstrated clinical efficacy, certain inherent properties within T-DM1 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1b894a20379dc9a76f654d4811688b
https://doi.org/10.1158/1535-7163.c.6542832
https://doi.org/10.1158/1535-7163.c.6542832
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
Immunohistochemical evaluation of HER2 expression in vivo cell line and patient-derived xenograft models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3ff9f7c862c417038a9aae79602e4f
https://doi.org/10.1158/1535-7163.22520937
https://doi.org/10.1158/1535-7163.22520937
Autor:
Puja Sapra, Hans-Peter Gerber, Christopher J. O'Donnell, Frank Loganzo, Edward Rosfjord, Judy Lucas, Lioudmila Tchistiakova, Frank Barletta, Tracey Clark, Martin Finkelstein, Hadi Falahatpisheh, Magali Guffroy, George Hu, Cynthia M. Rohde, Christine Hosselet, Jonathon Golas, Manoj B. Charati, Eric M. Bennett, Jeffrey Casavant, Jack Bikker, L. Nathan Tumey, Sujiet Puthenveetil, Kimberly Marquette, Bitha Narayanan, Dangshe Ma, Matthew Sung, Edmund I. Graziani
Includes Supplementary Materials and Methods, Data and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03aca1bc8d20f2fe143c7aa7d3d27294
https://doi.org/10.1158/1535-7163.22520934
https://doi.org/10.1158/1535-7163.22520934
Autor:
Sujiet Puthenveetil, Haiyin He, Frank Loganzo, Sylvia Musto, Jesse Teske, Michael Green, Xingzhi Tan, Christine Hosselet, Judy Lucas, L Nathan Tumey, Puja Sapra, Chakrapani Subramanyam, Christopher J O'Donnell, Edmund I Graziani
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178452 (2017)
Antibody drug conjugates (ADCs) are no longer an unknown entity in the field of cancer therapy with the success of marketed ADCs like ADCETRIS and KADCYLA and numerous others advancing through clinical trials. The pursuit of novel cytotoxic payloads
Externí odkaz:
https://doaj.org/article/a9c5fa6b52084c1a89614104f1774891
Publikováno v:
Tetrahedron Letters. 112:154229
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d11be24a7d2fcd28b6ec536def9c0446
https://doi.org/10.1016/j.tetlet.2022.154229
https://doi.org/10.1016/j.tetlet.2022.154229
Autor:
Kimberly Ann Marquette, Frank Loganzo, Puja Sapra, Dangshe Ma, George Hu, Sujiet Puthenveetil, Cynthia M. Rohde, Judy Lucas, L. Nathan Tumey, Matthew Sung, Christine Hosselet, Jonathon Golas, Manoj Charati, Edmund I. Graziani, Frank Barletta, Magali Guffroy, Martin Finkelstein, Jeffrey M. Casavant, Hadi Falahatpisheh, Bitha Narayanan, Jack A. Bikker, Hans-Peter Gerber, Eric M. Bennett, Lioudmila Tchistiakova, Tracey Clark, Edward Rosfjord, Christopher J. O’Donnell
Publikováno v:
Molecular cancer therapeutics. 19(10)
The approval of ado-trastuzumab emtansine (T-DM1) in HER2+ metastatic breast cancer validated HER2 as a target for HER2-specific antibody–drug conjugates (ADC). Despite its demonstrated clinical efficacy, certain inherent properties within T-DM1 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2262d08bf90166d80d9c9b49e52ffe5a
https://pubmed.ncbi.nlm.nih.gov/32747418
https://pubmed.ncbi.nlm.nih.gov/32747418
Background: In Europe cardiovascular disease (CVD) is responsible for 3.9 million deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to heart failure) the major cause of these CVD related deaths. Periodontitis is als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1b9ed61e8bfff0ee3366af4c18e13c9d
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2990012
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2990012
Autor:
Matthew Sung, Edmund I. Graziani, Paul Jasper, John E. Tolsma, Frank Barletta, Dangshe Ma, Piet H. van der Graaf, Edward Rosfjord, Tracey Clark, Alison Betts
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics
A modeling and simulation approach was used for quantitative comparison of a new generation HER2 antibody drug conjugate (ADC, PF-06804103) with trastuzumab-DM1 (T-DM1). To compare preclinical efficacy, the pharmacokinetic (PK)/pharmacodynamic (PD) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb671c4e8e42cc2410ccef7e753f3e38
https://pubmed.ncbi.nlm.nih.gov/32710210
https://pubmed.ncbi.nlm.nih.gov/32710210