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Prediction of the drug–drug interaction potential of the α1‐acid glycoprotein bound, CYP3A4/CYP2C9 metabolized oncology drug, erdafitinib

Autor: Frank Jacobs, Loeckie de Zwart, I. Goris, Mario Monshouwer, Rao N.V.S. Mamidi, Lilian Y. Li, Italo Poggesi, Jan Snoeys, Peter Verboven, Ellen Scheers, Inneke Wynant

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1107-1118 (2021)

Erdafitinib is a potent oral pan‐fibroblast growth factor receptor inhibitor being developed as oncology drug for patients with alterations in the fibroblast growth factor receptor pathway. Erdafitinib binds preferentially to α1‐acid glycoprotei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abbc9d1666772a5a4609f5ea1cec529
https://doi.org/10.1002/psp4.12682

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Akademický článek

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Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs

Autor: Michael F. Kelley, Cor G. M. Janssen, I. Goris, Rao N. V. S. Mamidi, Willem Meuldermans, Mark Bockx, Geert Mannens, Mark L. Kao, J. Hendrickx, Pieter Annaert

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 35(4)

The in vivo metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-], a novel neuromodulator, were investigated in mice, rats, rabbits, and dogs after oral administration of (14)C-RWJ-333369. Plasma, urine, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e21a6af2e8a6949f5203fea37e5fc12
https://pubmed.ncbi.nlm.nih.gov/17220243

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The absorption, metabolism, and excretion of the novel neuromodulator RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-) in humans

Autor: Willem Meuldermans, Geert Mannens, B. Verreet, Marc Bockx, M. Bialer, B. Van Hoof, Tom Verhaeghe, Mark L. Kao, Michael F. Kelley, S. Chien, J. Hendrickx, Cor G. M. Janssen, I. Goris

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 35(4)

RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-; CAS Registry Number 194085-75-1) is a novel neuromodulator in clinical development for the treatment of epilepsy. To study the disposition of RWJ-333369, eight healthy male subjects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72358f714432fbafa7650b88b20a8f03
https://pubmed.ncbi.nlm.nih.gov/16936066

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Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor

Autor: R C, Garner, I, Goris, A A E, Laenen, E, Vanhoutte, W, Meuldermans, S, Gregory, J V, Garner, D, Leong, M, Whattam, A, Calam, C A W, Snel

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 30(7)

Accelerator mass spectrometry (AMS) has been used in a human mass balance and metabolism study to analyze samples taken from four healthy male adult subjects administered nanoCurie doses of the farnesyl transferase inhibitor 14C-labeled (R)-6-[amino(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::970f121480671e7f8b038f410da987cf
https://pubmed.ncbi.nlm.nih.gov/12065441

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Akademický článek

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[Nursing diagnosis. Keys for its development]

Autor: J A, Guirao i Goris, A, Cuesta Zambrana, A, Benavent Garcés

Publikováno v: Revista de enfermeria (Barcelona, Spain). 22(7-8)

The authors carried out a study of the taxonomy used at the 1990 NANDA Conference. A few of the authors findings were some diagnostic labels were found to be imprecise; some of the diagnostic labels relate to causes which would only allow nurses to w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70e481285b98836fc42d02aff6c91b24
https://pubmed.ncbi.nlm.nih.gov/10514795

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Akademický článek

Features of Usіng Pulse-Doppler Radars for Determіnatіon Low-Altіtude Targets

Autor: G. Baranov, R. Gabruk, I. Gorishna

Publikováno v: Метрологія та прилади, Iss 2, Pp 62-66 (2019)

In this paper, we analyzed the features of Doppler processing in radars. In ground based radars, the amount of clutter in the radar receiver depends heavily on the radar-to-target geometry. The amount clutter is considerably higher when the radar bea

Externí odkaz: https://doaj.org/article/f255767b01e24bd9a32ca6fd7f19594f

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Akademický článek

Determination of Radar Features During Simulator Space Sensing with Radio Pulses of Short Duration

Autor: G. Baranov, R. Gabruk, I. Gorishna

Publikováno v: Метрологія та прилади, Iss 1, Pp 42-46 (2019)

In this paper, we analyzed the features of obtaining radar information, and also determined the advantages of using short pulses in comparison with pulses of long duration. In the course of the study it was determined that the range is limited by the

Externí odkaz: https://doaj.org/article/20af7cc44c0c4981a8f54d2efdf1b4d1

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