Zobrazeno 1 - 10
of 1 119
pro vyhledávání: '"I. Glass"'
Autor:
Masaki Mizutani, Sawako Omori, Noriko Yamane, Yo Suzuki, John I. Glass, Ray-Yuan Chuang, Takema Fukatsu, Shigeyuki Kakizawa
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Cloning and transfer of long-stranded DNA in the size of a bacterial whole genome has become possible by recent advancements in synthetic biology. For the whole genome cloning and whole genome transplantation, bacteria with small genomes have been ma
Externí odkaz:
https://doaj.org/article/3bdc3c6ae1b5459896f239ffac9c9b58
Autor:
Troy E. Sandberg, Kim S. Wise, Christopher Dalldorf, Richard Szubin, Adam M. Feist, John I. Glass, Bernhard O. Palsson
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107500- (2023)
Summary: The bacterial strain JCVI-syn3.0 stands as the first example of a living organism with a minimized synthetic genome, derived from the Mycoplasma mycoides genome and chemically synthesized in vitro. Here, we report the experimental evolution
Externí odkaz:
https://doaj.org/article/1feada2cbb2c4658a2ca0337974eaee2
Autor:
Drago Haas, Antje M. Thamm, Jiayi Sun, Lili Huang, Lijie Sun, Guillaume A. W. Beaudoin, Kim S. Wise, Claudia Lerma-Ortiz, Steven D. Bruner, Marian Breuer, Zaida Luthey-Schulten, Jiusheng Lin, Mark A. Wilson, Greg Brown, Alexander F. Yakunin, Inna Kurilyak, Jacob Folz, Oliver Fiehn, John I. Glass, Andrew D. Hanson, Christopher S. Henry, Valérie de Crécy-Lagard
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Analysis of the genes retained in the minimized Mycoplasma JCVI-Syn3A genome established that systems that repair or preempt metabolite damage are essential to life. Several genes known to have such functions were identified and experimental
Externí odkaz:
https://doaj.org/article/71126318982049979973bef57993dd2a
Autor:
Tai L. Ng, Erika J. Olson, Tae Yeon Yoo, H. Sloane Weiss, Yukiye Koide, Peter D. Koch, Nathan J. Rollins, Pia Mach, Tobias Meisinger, Trenton Bricken, Timothy Z. Chang, Colin Molloy, Jérôme Zürcher, Roger L. Chang, Timothy J. Mitchison, John I. Glass, Debora S. Marks, Jeffrey C. Way, Pamela A. Silver
Publikováno v:
mSystems, Vol 7, Iss 2 (2022)
ABSTRACT Suppression of the host innate immune response is a critical aspect of viral replication. Upon infection, viruses may introduce one or more proteins that inhibit key immune pathways, such as the type I interferon pathway. However, the abilit
Externí odkaz:
https://doaj.org/article/37ee1fa315624f72abfb551a9d58f267
Autor:
Peter H Kilmarx, Roger I Glass
Publikováno v:
PLoS Medicine, Vol 18, Iss 8, p e1003753 (2021)
Peter Kilmarx and Roger Glass discuss strengthening health research capabilities as a response to the COVID-19 pandemic.
Externí odkaz:
https://doaj.org/article/be91fbe98af04cd2bbf9fbdb4cf3d907
Autor:
Benjamin R. Gilbert, Zane R. Thornburg, Vinson Lam, Fatema-Zahra M. Rashid, John I. Glass, Elizabeth Villa, Remus T. Dame, Zaida Luthey-Schulten
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
JCVI-syn3A is a genetically minimal bacterial cell, consisting of 493 genes and only a single 543 kbp circular chromosome. Syn3A’s genome and physical size are approximately one-tenth those of the model bacterial organism Escherichia coli’s, and
Externí odkaz:
https://doaj.org/article/275f892b8aea4872ababbebf2f3bc710
Autor:
Yuliya Khilko, Philip D. Weyman, John I. Glass, Mark D. Adams, Melanie A. McNeil, Peter B. Griffin
Publikováno v:
BMC Biotechnology, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Custom synthesized DNA is in high demand for synthetic biology applications. However, current technologies to produce these sequences using assembly from DNA oligonucleotides are costly and labor-intensive. The automation and redu
Externí odkaz:
https://doaj.org/article/6228750aff684d0b8ced963f829646e9
Autor:
Roger I. Glass
Publikováno v:
Cost Effectiveness and Resource Allocation, Vol 16, Iss S1, Pp 1-3 (2018)
Abstract Rotavirus (RV) diarrhea is the most common cause of severe diarrhea in children worldwide and since 2006, vaccines have been available and recommended by WHO for use in all children. We developed protocols that countries could use to assess
Externí odkaz:
https://doaj.org/article/0426f6dc557d496e99cfb25251f8f910
Publikováno v:
Annals of Global Health, Vol 84, Iss 1, Pp 4-6 (2018)
Externí odkaz:
https://doaj.org/article/54b74b6c34ff47c6826143cd0ac2a8d2
Autor:
Zane R. Thornburg, Marcelo C. R. Melo, David Bianchi, Troy A. Brier, Cole Crotty, Marian Breuer, Hamilton O. Smith, Clyde A. Hutchison, John I. Glass, Zaida Luthey-Schulten
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
JCVI-syn3A is a minimal bacterial cell with a 543 kbp genome consisting of 493 genes. For this slow growing minimal cell with a 105 min doubling time, we recently established the essential metabolism including the transport of required nutrients from
Externí odkaz:
https://doaj.org/article/62344af4b8634090bde8bad4fb32b5ce